PNRC2 and DCP1A

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid, two hybrid)

		PNRC2	DCP1A
Gene Name		proline-rich nuclear receptor coactivator 2	decapping mRNA 1A
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Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus	Cytoplasmic MRNA Processing Body Nucleus Cytosol Membrane
	Molecular Function	Protein Binding	Protein Binding Hydrolase Activity Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Transcription, DNA-templated Regulation Of Transcription, DNA-templated Deadenylation-independent Decapping Of Nuclear-transcribed MRNA	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Heart rate ( 23583979)
Protein-Protein Interactions		20 interactors: AR DCP1A ESR1 ESR2 ESRRA ESRRG GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SF1 SPAG9 XRCC6 ZBTB16 ZBTB48	14 interactors: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 PAXIP1 PNRC2 RITA1 SMAD4 TTF2 UPF1 XRN1 YWHAG
Entrez ID		55629	55802
HPRD ID		17871	06113
Ensembl ID		ENSG00000189266	ENSG00000162290
Uniprot IDs		Q9NPJ4	B4DHN9 Q9NPI6 U3KQU1
PDB IDs		4B6H	2WX3 4B6H
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Transcription From RNA Polymerase II Promoter Response To Lipid Response To Organic Cyclic Compound Response To Hormone Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Organic Substance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Organ Development Response To Organic Substance Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process System Development Developmental Process Involved In Reproduction Prostate Gland Development Sex Differentiation Multicellular Organismal Development Anatomical Structure Development Regulation Of Metabolic Process	MRNA Metabolic Process RNA Metabolic Process Gene Expression Histone MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Transcription, DNA-templated RNA Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleic Acid Phosphodiester Bond Hydrolysis MiRNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Peptidyl-lysine Acetylation Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Regulation Of Protein Metabolic Process Positive Regulation Of Protein Acetylation Epidermal Growth Factor Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Fibroblast Growth Factor Regulation Of RNA Biosynthetic Process Gene Silencing By MiRNA Regulation Of RNA Metabolic Process
Tagcloud ?		2d af alternatives biologically circular coactivators cognate competitive confirms constitutes coregulator coregulators dichroism ecd eralpha eralpha17p exception exhaustive governing grb2 issued motifs polyproline ppii pxxp sh3 spectroscopy transductions	appears blockade bodies caf1 ccr4 cleavage coincident cytoplasmic decapping directed dispersion disrupts eif2alpha enter evh1 gfp infection infectious linking mammalian pan2 pan3 pkr poliovirus restricted restricts surprisingly translation translational
Tagcloud (Difference) ?		2d af alternatives biologically circular coactivators cognate competitive confirms constitutes coregulator coregulators dichroism ecd eralpha eralpha17p exception exhaustive governing grb2 issued motifs polyproline ppii pxxp sh3 spectroscopy transductions	appears blockade bodies caf1 ccr4 cleavage coincident cytoplasmic decapping directed dispersion disrupts eif2alpha enter evh1 gfp infection infectious linking mammalian pan2 pan3 pkr poliovirus restricted restricts surprisingly translation translational
Tagcloud (Intersection) ?