CLIC5 and IQGAP1

Number of citations of the paper that reports this interaction (PMID 10793131)
29

Data Source:
HPRD (in vitro)

		CLIC5	IQGAP1
Gene Name		chloride intracellular channel 5	IQ motif containing GTPase activating protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Microtubule Organizing Center Cell Cortex Actin Cytoskeleton Stereocilium Chloride Channel Complex Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Microtubule Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Microtubule Cytoskeleton Lateral Plasma Membrane Cell Junction Axon Growth Cone Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Leading Edge Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Extracellular Vesicular Exosome
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding	GTPase Inhibitor Activity GTPase Activator Activity Ras GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Complex Binding Protein Serine/threonine Kinase Activator Activity Rac GTPase Binding
	Biological Process	Diet Induced Thermogenesis Transport Chloride Transport Female Pregnancy Sensory Perception Of Sound Protein Localization Regulation Of Ion Transmembrane Transport Neuromuscular Process Controlling Balance Auditory Receptor Cell Stereocilium Organization Chloride Transmembrane Transport	Regulation Of Cytokine Production Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Insulin Secretion Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Glomerular Visceral Epithelial Cell Development Neuron Projection Extension
Pathways			Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion Nephrin interactions
Drugs
Diseases
GWAS		Periodontal microbiota ( 22699663)
Protein-Protein Interactions		6 interactors: ACTA1 ACTN1 EZR GSN IQGAP1 SRPK1	24 interactors: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CLIC5 CLIP1 CTNNB1 CYBB EZR GRIA4 KDR MAPK1 MEN1 NPHS1 PDLIM7 PRKACA RAC1 S100B STAU1 TSG101 YWHAQ
Entrez ID		53405	8826
HPRD ID		06292	04541
Ensembl ID		ENSG00000112782	ENSG00000140575
Uniprot IDs		Q49AE1 Q53G01 Q9NZA1	P46940
PDB IDs			1X0H 2RR8 3FAY 3I6X
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Cytoskeleton Organization Actin Filament-based Process Cell Development Response To Metal Ion Cytoskeleton Organization Actin Filament Bundle Assembly Response To Inorganic Substance Growth Organelle Organization Cell Differentiation Tissue Development Cellular Response To Metal Ion Skeletal Muscle Fiber Adaptation Cellular Response To Inorganic Substance Cellular Component Assembly Cell Growth Cell Projection Morphogenesis Cell Part Morphogenesis Protein Localization To Tight Junction Epithelial Cell Development Membrane To Membrane Docking Anatomical Structure Morphogenesis Cell Morphogenesis Skeletal Muscle Thin Filament Assembly Response To Stimulus Anatomical Structure Development Developmental Growth Cell Projection Organization Protein Localization To Cell Junction Skeletal Myofibril Assembly Sperm Chromatin Condensation Skeletal Muscle Adaptation Glomerular Visceral Epithelial Cell Development Cytoskeletal Anchoring At Plasma Membrane Developmental Process Response To Folic Acid Actin Filament Severing Microvillus Assembly Vesicle-mediated Transport Microvillus Organization Glomerular Visceral Epithelial Cell Differentiation Cellular Response To Cadmium Ion Actin Crosslink Formation Filopodium Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Response To Extracellular Stimulus Positive Regulation Of Viral Genome Replication Barbed-end Actin Filament Capping	Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Epithelium Development Cell Development Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Anatomical Structure Morphogenesis Multicellular Organismal Development Epithelial Cell Development System Development Epithelial Cell Differentiation Tissue Development Cell Differentiation Developmental Process Positive Regulation Of Signal Transduction Organ Development Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Localization Cell-cell Junction Organization Nervous System Development Regulation Of Cell Proliferation Positive Regulation Of Organelle Organization Regulation Of Cell Differentiation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Osteoblast Differentiation Epidermis Development Apoptotic Process Epidermal Cell Differentiation Organelle Organization Immune System Process Regulation Of Epithelial Cell Proliferation Programmed Cell Death Regulation Of Cytoskeleton Organization Cell Death Death Cell Morphogenesis Response To External Stimulus Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Protein Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Protein Complex Assembly Neuron Differentiation Protein Localization
Tagcloud ?		assayed buck chose conditional cxcl13 dichotomization dichotomous dr ffpe hrneg hrpos ics incorporating microarray multigene multiplexed nodal optimized platforms prognostically proved reaffirmed rtpcr signatures subtyping tneg tnfrsf17 today xcl2	activating binds canonical clinicopathological coexpression correlating cytoplamic cytoplasm dishevelled dvl embryos expressions growths gtpase localization lymph membranous metastase metastases modulator nodal nsclc nucleus poor prognosis resection wnt xenopus
Tagcloud (Difference) ?		assayed buck chose conditional cxcl13 dichotomization dichotomous dr ffpe hrneg hrpos ics incorporating microarray multigene multiplexed optimized platforms prognostically proved reaffirmed rtpcr signatures subtyping tneg tnfrsf17 today xcl2	activating binds canonical clinicopathological coexpression correlating cytoplamic cytoplasm dishevelled dvl embryos expressions growths gtpase localization lymph membranous metastase metastases modulator nsclc nucleus poor prognosis resection wnt xenopus
Tagcloud (Intersection) ?		nodal