CLIC5 and ACTA1

Number of citations of the paper that reports this interaction (PMID 10793131)
29

Data Source:
HPRD (in vitro)

		CLIC5	ACTA1
Gene Name		chloride intracellular channel 5	actin, alpha 1, skeletal muscle
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Microtubule Organizing Center Cell Cortex Actin Cytoskeleton Stereocilium Chloride Channel Complex Extracellular Vesicular Exosome	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Diet Induced Thermogenesis Transport Chloride Transport Female Pregnancy Sensory Perception Of Sound Protein Localization Regulation Of Ion Transmembrane Transport Neuromuscular Process Controlling Balance Auditory Receptor Cell Stereocilium Organization Chloride Transmembrane Transport	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS		Periodontal microbiota ( 22699663)
Protein-Protein Interactions		6 interactors: ACTA1 ACTN1 EZR GSN IQGAP1 SRPK1	107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		53405	58
HPRD ID		06292	00030
Ensembl ID		ENSG00000112782	ENSG00000143632
Uniprot IDs		Q49AE1 Q53G01 Q9NZA1	P68133 Q5T8M7
PDB IDs			1T44
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Cytoskeleton Organization Actin Filament-based Process Cell Development Response To Metal Ion Cytoskeleton Organization Actin Filament Bundle Assembly Response To Inorganic Substance Growth Organelle Organization Cell Differentiation Tissue Development Cellular Response To Metal Ion Skeletal Muscle Fiber Adaptation Cellular Response To Inorganic Substance Cellular Component Assembly Cell Growth Cell Projection Morphogenesis Cell Part Morphogenesis Protein Localization To Tight Junction Epithelial Cell Development Membrane To Membrane Docking Anatomical Structure Morphogenesis Cell Morphogenesis Skeletal Muscle Thin Filament Assembly Response To Stimulus Anatomical Structure Development Developmental Growth Cell Projection Organization Protein Localization To Cell Junction Skeletal Myofibril Assembly Sperm Chromatin Condensation Skeletal Muscle Adaptation Glomerular Visceral Epithelial Cell Development Cytoskeletal Anchoring At Plasma Membrane Developmental Process Response To Folic Acid Actin Filament Severing Microvillus Assembly Vesicle-mediated Transport Microvillus Organization Glomerular Visceral Epithelial Cell Differentiation Cellular Response To Cadmium Ion Actin Crosslink Formation Filopodium Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Response To Extracellular Stimulus Positive Regulation Of Viral Genome Replication Barbed-end Actin Filament Capping	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly
Tagcloud ?		assayed buck chose conditional cxcl13 dichotomization dichotomous dr ffpe hrneg hrpos ics incorporating microarray multigene multiplexed nodal optimized platforms prognostically proved reaffirmed rtpcr signatures subtyping tneg tnfrsf17 today xcl2	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Difference) ?		assayed buck chose conditional cxcl13 dichotomization dichotomous dr ffpe hrneg hrpos ics incorporating microarray multigene multiplexed nodal optimized platforms prognostically proved reaffirmed rtpcr signatures subtyping tneg tnfrsf17 today xcl2	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Intersection) ?