PLAGL1 and PIAS2

Number of citations of the paper that reports this interaction (PMID 15208321)
6

Data Source:
BioGRID (pull down)

		PLAGL1	PIAS2
Gene Name		pleiomorphic adenoma gene-like 1	protein inhibitor of activated STAT, 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle	Nucleus PML Body Nuclear Speck
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Metal Ion Binding	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Transcription From RNA Polymerase II Promoter Apoptotic Process Cell Cycle Arrest Cell Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CREBBP DAXX EP300 KAT2B PIAS2 PML SMAD3 TP53 UBE2I	68 interactors: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CHMP4B CLDN2 CTBP1 DDX39B ELK1 ESR1 ESR2 FLI1 GFAP GFI1 GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 ITGB5 JUN MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 MYCN NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I ZBED1 ZBTB8A ZNF451
Entrez ID		5325	9063
HPRD ID		16010	06944
Ensembl ID		ENSG00000118495	ENSG00000078043
Uniprot IDs		A1YLA1 A1YLA2 Q9UM63	O75928
PDB IDs			2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Viral Process N-terminal Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Cell Cycle Process Negative Regulation Of Transcription, DNA-templated Peptidyl-lysine Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Hypoxia Rhythmic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Transcription, DNA-templated Apoptotic Signaling Pathway RNA Biosynthetic Process N-terminal Protein Amino Acid Modification Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Notch Signaling Pathway Cell Cycle Arrest Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Deacetylation Regulation Of Signaling Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Gene Expression Mitotic Cell Cycle Process Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Somitogenesis Chromatin Organization Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Somite Development Protein Stabilization	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein Sumoylation Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Gland Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cellular Response To Lipid Macromolecule Biosynthetic Process Cellular Response To Stimulus Regulation Of Cellular Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Cell Proliferation Regulation Of Signaling Signaling
Tagcloud ?		20mug 25mug 5mug actionable bisulfite deemed dmrs exposures h19 hek ig igf2 imprinted imprinting meg3 mest methylation nnat pb peg1 peg10 peg3 physiologically pyrosequencing reportable seventy sgce utero vulnerable	293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Difference) ?		20mug 25mug 5mug actionable bisulfite deemed dmrs exposures h19 ig igf2 imprinted imprinting meg3 mest methylation nnat pb peg1 peg10 peg3 physiologically pyrosequencing reportable seventy sgce utero vulnerable	293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Intersection) ?		hek