PIAS2 and ZNF451

Number of citations of the paper that reports this interaction (PMID 18656483)
7

Data Source:
BioGRID (two hybrid)

		PIAS2	ZNF451
Gene Name		protein inhibitor of activated STAT, 2	zinc finger protein 451
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus PML Body Nuclear Speck	Nucleus
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		68 interactors: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CHMP4B CLDN2 CTBP1 DDX39B ELK1 ESR1 ESR2 FLI1 GFAP GFI1 GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 ITGB5 JUN MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 MYCN NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I ZBED1 ZBTB8A ZNF451	23 interactors: AR CALCOCO2 CDC5L CPTP CREB1 FXR2 HTT JMJD6 KDM1A LZTR1 PCBD1 PIAS1 PIAS2 PRMT1 PRMT8 PRPF40A RAP1GDS1 RNF40 SNIP1 SUMO1 SUV39H1 UBC UBE2I
Entrez ID		9063	26036
HPRD ID		06944	10332
Ensembl ID		ENSG00000078043	ENSG00000112200
Uniprot IDs		O75928	B4DYS2 Q96JY2 Q9Y4E5
PDB IDs		2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein Sumoylation Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Gland Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cellular Response To Lipid Macromolecule Biosynthetic Process Cellular Response To Stimulus Regulation Of Cellular Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Cell Proliferation Regulation Of Signaling Signaling	Regulation Of Gene Expression Protein Sumoylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Histone Modification Peptidyl-amino Acid Modification Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Organelle Organization RNA Metabolic Process Cellular Protein Modification Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Chromatin Modification Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Protein Modification By Small Protein Conjugation Heterocycle Metabolic Process Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Peptidyl-arginine N-methylation Nucleobase-containing Compound Metabolic Process Histone H4-R3 Methylation Regulation Of Innate Immune Response Diencephalon Development Regulation Of Binding Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Histone Arginine Methylation Viral Process Peptidyl-arginine Methylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast	acetylation acts attenuates beta blocks bodies causes cofactor corepressor demonstrating depletion enhances functionally h3k9 inhibits interacts localized mechanistically negatively physically promoters promyelocytic recruit regulates responses smad3 taken tgf transcriptional
Tagcloud (Difference) ?		293t alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast	acetylation attenuates beta blocks bodies causes cofactor corepressor demonstrating depletion enhances functionally h3k9 inhibits interacts localized mechanistically negatively physically promoters promyelocytic recruit regulates responses smad3 taken tgf transcriptional
Tagcloud (Intersection) ?		acts