PKD1 and ATF7IP

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		PKD1	ATF7IP
Gene Name		polycystic kidney disease 1 (autosomal dominant)	activating transcription factor 7 interacting protein
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Polycystin Complex Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cilium Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Primary Cilium Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Ion Channel Binding	Transcription Corepressor Activity Protein Binding ATPase Activity
	Biological Process	Cartilage Condensation In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Nitrogen Compound Metabolic Process Organelle Organization Cell Cycle Arrest Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration JAK-STAT Cascade Heart Development Anatomical Structure Morphogenesis Single Organismal Cell-cell Adhesion Peptidyl-serine Phosphorylation Spinal Cord Development Neural Tube Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Binding Response To Fluid Shear Stress Cytoplasmic Sequestering Of Transcription Factor Skin Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Transcription, DNA-templated Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		25 interactors: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 MARK2 PKD2 PTK2 PXN RGS7 SIAH1 SRC TLN1 VCL VIM	68 interactors: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CSPG4 DISC1 DMTF1 DNM2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO3 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		5310	55729
HPRD ID		03203	09811
Ensembl ID		ENSG00000008710	ENSG00000171681
Uniprot IDs		P98161	B3KNI7 B3KQF8 F5GX74 G3V1U0 Q6VMQ6
PDB IDs		1B4R	2RPQ
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cytoskeleton Organization Movement Of Cell Or Subcellular Component Cell Junction Assembly Cell-cell Junction Organization Cellular Response To Organonitrogen Compound Regulation Of Cellular Component Movement Organelle Organization Cellular Response To Organic Substance Cellular Response To Indole-3-methanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Activation Regulation Of Body Fluid Levels Response To Organic Substance Response To Organonitrogen Compound Blood Coagulation Regulation Of Cell Motility Hemostasis Anatomical Structure Development Cell Development Cell Adhesion Adherens Junction Assembly Cellular Component Assembly Regulation Of Locomotion Cell-cell Junction Assembly Cell Activation Response To Wounding Generation Of Neurons Cell Morphogenesis Involved In Differentiation Locomotion Anatomical Structure Morphogenesis Cell Differentiation Neurogenesis Multicellular Organismal Development Developmental Process System Development Response To Stimulus Regulation Of Cell Migration Wound Healing Actin Filament-based Process Nervous System Development Response To Peptide Hormone Cellular Localization Response To Stress Response To Peptide Cellular Response To Peptide Hormone Stimulus Protein Complex Assembly Cellular Response To Peptide Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility	Transcription Initiation From RNA Polymerase II Promoter Viral Process Positive Regulation Of Viral Transcription Cell Differentiation DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Regulation Of Viral Transcription 7-methylguanosine RNA Capping Positive Regulation Of Viral Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Elongation RNA Biosynthetic Process Developmental Process Transcription, DNA-templated Anatomical Structure Development Regulation Of Viral Process Post-Golgi Vesicle-mediated Transport Macromolecule Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Gene Expression RNA Metabolic Process Extracellular Matrix Disassembly Cellular Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis System Development Cell Junction Assembly Cardiovascular System Development Stem Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Biosynthetic Process Nervous System Development Neurogenesis Angiogenesis Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Golgi To Plasma Membrane Protein Transport Somatic Stem Cell Maintenance Protein Sumoylation Positive Regulation Of Gene Expression Multicellular Organismal Development Generation Of Neurons Stem Cell Development Blood Vessel Development Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Axon Guidance Golgi Vesicle Transport Vasculature Development
Tagcloud ?		acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd2 polycystic polycystin progressive severity	acgh adherent cce cd15 cd29 cd44 cd90 continuously csmd1 cultivation cytokeratins cytometric devastating doubling explant grin2b hypercalcemia hypercalcemic karyotype lentiviral oligo outgrowth paralleled park2 proliferating sccoht similarities subpopulations vimentin
Tagcloud (Difference) ?		acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd2 polycystic polycystin progressive severity	acgh adherent cce cd15 cd29 cd44 cd90 continuously csmd1 cultivation cytokeratins cytometric devastating doubling explant grin2b hypercalcemia hypercalcemic karyotype lentiviral oligo outgrowth paralleled park2 proliferating sccoht similarities subpopulations vimentin
Tagcloud (Intersection) ?