NOV and DLL1

Number of citations of the paper that reports this interaction (PMID 12050162)
45

Data Source:
HPRD (in vitro, in vivo)

		NOV	DLL1
Gene Name		nephroblastoma overexpressed	delta-like 1 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Axon Dendrite Neuronal Cell Body Intracellular Membrane-bounded Organelle	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Integrin Binding Insulin-like Growth Factor Binding Growth Factor Activity Heparin Binding	Notch Binding Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Cell Growth Cell Adhesion Signal Transduction Cell-cell Signaling Regulation Of Gene Expression Negative Regulation Of Cell Death	Cell Fate Determination Somite Specification Heart Looping Notch Signaling Pathway Notch Receptor Processing Cell-cell Signaling Determination Of Left/right Symmetry Compartment Pattern Specification Hemopoiesis Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Interleukin-10 Production Negative Regulation Of Auditory Receptor Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Inner Ear Development Left/right Axis Specification Proximal Tubule Development Loop Of Henle Development Neuronal Stem Cell Maintenance
Pathways			Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs		Insulin Regular Insulin, porcine
Diseases
GWAS		Blood pressure ( 21909110) Hypertension ( 21626137)	Type 1 diabetes ( 21980299)
Protein-Protein Interactions		14 interactors: ADSL CDKN1A CTGF DLL1 FBLN1 FN1 GJA1 IGF1 IGF2 INS ITGAV NOTCH1 POLR2L S100A4	10 interactors: ADAM10 CNKSR3 MAGI2 MFNG NOTCH1 NOTCH2 NOTCH3 NOV POFUT1 PSEN1
Entrez ID		4856	28514
HPRD ID		01291	05957
Ensembl ID		ENSG00000136999	ENSG00000198719
Uniprot IDs		P48745	O00548
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Wounding Wound Healing Regulation Of Growth Regulation Of Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Developmental Process Tissue Development Positive Regulation Of Protein Metabolic Process Cell Development Cell Differentiation Positive Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Cellular Component Organization Cardiovascular System Development Multicellular Organismal Development Vasculature Development Anatomical Structure Development Positive Regulation Of Cell Cycle Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process System Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Glycogen Metabolic Process Anatomical Structure Morphogenesis Digestive System Development Tube Development Positive Regulation Of Mitotic Nuclear Division Response To Stress Compartment Pattern Specification Blood Vessel Morphogenesis Tissue Regeneration Response To Organonitrogen Compound Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Heart Looping Response To Peptide Regulation Of Cell Cycle Process Enzyme Linked Receptor Protein Signaling Pathway Determination Of Heart Left/right Asymmetry Secretion By Cell Blood Vessel Development Embryonic Heart Tube Morphogenesis Organ Development	Notch Receptor Processing Notch Signaling Pathway Nervous System Development Anatomical Structure Morphogenesis Pattern Specification Process Blood Vessel Development Vasculature Development Epithelium Development Glomerulus Development Cell Surface Receptor Signaling Pathway Cell Fate Commitment Multicellular Organismal Development Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Interleukin-4 Production Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Generation Of Neurons Cardiovascular System Development Developmental Process Neurogenesis Membrane Protein Ectodomain Proteolysis Tissue Development Nephron Development System Development Cell Development Embryonic Limb Morphogenesis Myeloid Dendritic Cell Differentiation Glomerulus Vasculature Development Morphogenesis Of An Epithelium Heart Development Transcription Initiation From RNA Polymerase II Promoter Organ Development Myeloid Dendritic Cell Activation Neuron Differentiation Limb Morphogenesis Regulation Of Neuron Differentiation Embryo Development Negative Regulation Of Neuron Differentiation Limb Development Regulation Of Cell Migration Membrane Protein Proteolysis Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Morphogenesis Regulation Of Cell Motility
Tagcloud ?		autologous avian chicken cloned conserved element elements elevated encodes homolog igfii interrelated inversely kidney might nephroblastomas novh oncogene overexpressed predominantly proto putative relative represent sequenced stromal tumors wilms wt1	ameliorates asked commitment conditional corroborate duchenne dystrophic dystrophies efficaciousness engraftment eudract hold impairs interplay mab mabs mef2c mesoangioblasts muscular myogenic notch notch1 pericytes played potentiate regenerate regenerative satellite tuning
Tagcloud (Difference) ?		autologous avian chicken cloned conserved element elements elevated encodes homolog igfii interrelated inversely kidney might nephroblastomas novh oncogene overexpressed predominantly proto putative relative represent sequenced stromal tumors wilms wt1	ameliorates asked commitment conditional corroborate duchenne dystrophic dystrophies efficaciousness engraftment eudract hold impairs interplay mab mabs mef2c mesoangioblasts muscular myogenic notch notch1 pericytes played potentiate regenerate regenerative satellite tuning
Tagcloud (Intersection) ?