NF2 and TSC1

Number of citations of the paper that reports this interaction (PMID 12226091)
9

Data Source:
HPRD (in vivo)

		NF2	TSC1
Gene Name		neurofibromin 2 (merlin)	tuberous sclerosis 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Early Endosome Cytoskeleton Plasma Membrane Adherens Junction Membrane Extrinsic Component Of Membrane Lamellipodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Apical Part Of Cell Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Actin Filament Plasma Membrane Cell Cortex Membrane Lamellipodium Growth Cone TSC1-TSC2 Complex Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	Actin Binding Protein Binding	Protein Binding GTPase Regulator Activity GTPase Activating Protein Binding Protein N-terminus Binding Chaperone Binding
	Biological Process	Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Ectoderm Development Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Schwann Cell Proliferation Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Protein Stability Regulation Of Hippo Signaling Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Positive Regulation Of Stress Fiber Assembly Lens Fiber Cell Differentiation Regulation Of Protein Localization To Nucleus Regulation Of Neural Precursor Cell Proliferation	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell Cycle Arrest Cell-matrix Adhesion Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Activation Of Rho GTPase Activity Response To Insulin Myelination Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Synapse Organization Protein Stabilization Protein Heterooligomerization Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation
Pathways			Inhibition of TSC complex formation by PKB Insulin receptor signalling cascade IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling IRS-related events mTOR signalling Inhibition of TSC complex formation by PKB IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS		Carotid atherosclerosis in HIV infection ( 20009918)	Psoriasis ( 19169254)
Protein-Protein Interactions		24 interactors: AGAP2 AKT1 CCNB1IP1 CD44 CTNNB1 ERBB2 EZR HGS ITGB1 KDM1A MED28 PAK1 PXN PYGO2 RALGDS SCHIP1 SDCBP SGSM3 SLC9A3R1 SPTBN1 TARBP2 TSC1 VPRBP XPO1	23 interactors: AKT1 ATXN1 CCNB1 CDK1 EZR IKBKB KDM1A MSN NEFL NF2 NGFRAP1 PLK1 PRMT6 RDX RHEB TBC1D7 TSC2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		4771	7248
HPRD ID		06980	05594
Ensembl ID		ENSG00000186575	ENSG00000165699
Uniprot IDs		P35240	Q32NF0 Q86WV8 Q92574
PDB IDs		1H4R 3U8Z
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cell Development Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Cell Projection Organization Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Growth Factor Axon Guidance Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Anatomical Structure Development Positive Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Localization Regulation Of Protein Kinase Activity Cell Morphogenesis Cell-matrix Adhesion Signal Transduction Nervous System Development Axonogenesis Cellular Response To Organic Substance Regulation Of Kinase Activity Movement Of Cell Or Subcellular Component Protein Localization Regulation Of Catalytic Activity Multicellular Organismal Development Developmental Process Cellular Localization Anatomical Structure Morphogenesis Axon Development Response To Stimulus Cellular Response To Growth Factor Stimulus	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Regulation Of Apoptotic Process Membrane Organization Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Localization Neurotrophin Signaling Pathway Regulation Of Signal Transduction Cellular Localization Regulation Of Intracellular Transport Regulation Of Signaling Positive Regulation Of Transport Cellular Protein Localization Regulation Of Cellular Localization Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Protein Localization Cellular Response To Insulin Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Response To Growth Factor Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Cell Death Negative Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Protein Targeting G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Phase Transition Apoptotic Process Regulation Of Cellular Process Cell Cycle Phase Transition Response To Peptide Hormone
Tagcloud ?		22q allele alleles analysed assumed candidates carcinomas colorectal coupled cys digestive e1a gastric gene heterozygosity inactivation located missense mutation neurofibromatosis p300 participates rich sequencing somatic sscp suppressor though thought	abnormally autosomal deprived formations glutamine hamartin immunosuppressant impairments indicators lifespan master mechanistically mtorc1 neurocognitive neuropsychological orally physiologically premature rapamycin s6 seizures starvation surrogate tsc2 tuber tuberin tuberous withdrawal
Tagcloud (Difference) ?		22q allele alleles analysed assumed candidates carcinomas colorectal coupled cys digestive e1a gastric gene heterozygosity inactivation located missense mutation neurofibromatosis p300 participates rich sequencing somatic sscp suppressor though thought	abnormally autosomal deprived formations glutamine hamartin immunosuppressant impairments indicators lifespan master mechanistically mtorc1 neurocognitive neuropsychological orally physiologically premature rapamycin s6 seizures starvation surrogate tsc2 tuber tuberin tuberous withdrawal
Tagcloud (Intersection) ?