TSC1 and ATXN1

Number of citations of the paper that reports this interaction (PMID 23275563)
1

Data Source:
BioGRID (two hybrid)

		TSC1	ATXN1
Gene Name		tuberous sclerosis 1	ataxin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Cell Cortex Membrane Lamellipodium Growth Cone TSC1-TSC2 Complex Intracellular Membrane-bounded Organelle Protein Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear RNA Export Factor Complex Nuclear Inclusion Body Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding GTPase Regulator Activity GTPase Activating Protein Binding Protein N-terminus Binding Chaperone Binding	DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Poly(U) RNA Binding Poly(G) Binding Identical Protein Binding Protein Self-association
	Biological Process	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell Cycle Arrest Cell-matrix Adhesion Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Activation Of Rho GTPase Activity Response To Insulin Myelination Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Synapse Organization Protein Stabilization Protein Heterooligomerization Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Processing Adult Locomotory Behavior Visual Learning Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Nuclear Export Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		Inhibition of TSC complex formation by PKB Insulin receptor signalling cascade IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling IRS-related events mTOR signalling Inhibition of TSC complex formation by PKB IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS		Psoriasis ( 19169254)	Amyotrophic lateral sclerosis ( 19451621) Gambling ( 22780124) Major depressive disorder ( 23377640)
Protein-Protein Interactions		23 interactors: AKT1 ATXN1 CCNB1 CDK1 EZR IKBKB KDM1A MSN NEFL NF2 NGFRAP1 PLK1 PRMT6 RDX RHEB TBC1D7 TSC2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	252 interactors: ACACA ACOT7 ADCY6 ADD3 AHDC1 AKT1 ANKHD1 ANP32A APBB1 ARHGAP32 ARID5A ASNS ATF5 ATP1A3 ATP6V0D1 ATXN1L ATXN2 ATXN2L BAALC BASP1 BATF2 BEND2 BTG3 C1orf94 C2orf27B CAMK2B CCDC136 CCNK CDIP1 CDK6 CFL1 CHRNA7 CIC CIRBP CLASRP CLCN2 CLEC4F COIL CPSF7 CREM CRIP2 CRK CRY2 CST3 DAZAP2 DCTN3 DHRSX DHX37 DIXDC1 DMPK DNAJA3 DOCK5 DZIP3 EFEMP2 EHMT1 EIF1AY EIF1B EIF3F EIF4ENIF1 ELP5 ENTPD6 ESRP1 ESRRA ETV4 FAM193B FAM21C FAM46A FAM46B FAR1 FAT4 FDPS FHL2 FOSL1 FUBP3 FYN GAPDH GATAD1 GCA GCFC2 GGA2 GMEB2 GPATCH8 GSPT1 HEY2 HEYL HIST1H3A HIVEP1 HNRNPLL HOTAIR HPCAL1 HSFX1 HSPA1A HYPM IGF2R IL34 ILVBL IMMT IPO8 IST1 ITGB4 KAT5 KAT6A KCNAB2 KCTD15 KIAA1549L KIAA2026 KIF22 KLF11 KLHL12 KLHL8 KMT2B LASP1 LDB1 LITAF LOC401442 LOXL1 LPAR2 LRSAM1 MAGEB18 MAGEB2 MAGEB6 MATN2 MBP MED15 METTL17 MLST8 MSMO1 MSX2 MTERF4 MYO18A NARS NCAM1 NCOR1 NCOR2 NLK NPHP3 NR4A1 NUDT21 NUMBL NUTM2B OAZ1 OPCML OTX2 PEPD PHPT1 PIAS1 PIM2 PLEKHB1 PML POM121 PPAT PPP6R2 PQBP1 PRDM1 PRR20A PRRC2A PRRC2B PSMC3 PSPH PTGDS PUM1 QKI QRICH1 R3HDM1 R3HDM2 RAD54L2 RAI2 RAPGEF1 RAPGEF4 RBFOX1 RBFOX2 RBM26 RBPMS RCN1 REL RHOXF2 RNF31 RNF4 SAR1A SEMA4G SETD2 SF1 SGMS1 SIX5 SLC25A51 SLC4A2 SLC51A SLC6A13 SMARCC2 SPEN SREBF1 SREBF2 ST6GALNAC6 STAC2 STAM2 SUGP2 SUMO1 SUMO2 SUPT20H SV2A SYBU TBC1D5 TBX15 TCAP TCEANC TCTA TDP2 TMX2 TOLLIP TOMM20 TOX4 TP53I11 TRAF2 TRIM32 TRIM38 TRIP6 TSC1 TTC19 U2AF2 UBAP2L UBE2E3 UBE2I UBQLN4 UHRF1BP1L UHRF2 UNK USP54 USP7 VCP VSNL1 VSTM2L WBSCR16 WNK1 WNK2 YWHAE YWHAZ YY1AP1 ZBTB32 ZC3H10 ZC3H7B ZCCHC13 ZHX1 ZHX2 ZHX3 ZNF276 ZNF488 ZNF609 ZNF804A ZSCAN1 ZSWIM8 ZXDC ZYX
Entrez ID		7248	6310
HPRD ID		05594	03333
Ensembl ID		ENSG00000165699	ENSG00000124788
Uniprot IDs		Q32NF0 Q86WV8 Q92574	P54253 Q96FF1
PDB IDs			1OA8 4APT 4AQP 4J2J 4J2L
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Regulation Of Apoptotic Process Membrane Organization Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Localization Neurotrophin Signaling Pathway Regulation Of Signal Transduction Cellular Localization Regulation Of Intracellular Transport Regulation Of Signaling Positive Regulation Of Transport Cellular Protein Localization Regulation Of Cellular Localization Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Protein Localization Cellular Response To Insulin Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Response To Growth Factor Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Cell Death Negative Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Protein Targeting G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Phase Transition Apoptotic Process Regulation Of Cellular Process Cell Cycle Phase Transition Response To Peptide Hormone	Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Multicellular Organismal Development Positive Regulation Of Metabolic Process Developmental Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Differentiation System Development Anatomical Structure Development Cell Differentiation Organ Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Cellular Response To Organic Substance Cellular Process Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Generation Of Neurons Response To Stimulus
Tagcloud ?		abnormally autosomal deprived formations glutamine hamartin immunosuppressant impairments indicators lifespan master mechanistically mtorc1 neurocognitive neuropsychological orally physiologically premature rapamycin s6 seizures starvation surrogate tsc2 tuber tuberin tuberous withdrawal	akap6 atf7 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		abnormally autosomal deprived formations glutamine hamartin immunosuppressant impairments indicators lifespan master mechanistically mtorc1 neurocognitive neuropsychological orally physiologically premature rapamycin s6 seizures starvation surrogate tsc2 tuber tuberin tuberous withdrawal	akap6 atf7 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?