MYO6 and TAX1BP1

Number of citations of the paper that reports this interaction (PMID 17635994)
14

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		MYO6	TAX1BP1
Gene Name		myosin VI	Tax1 (human T-cell leukemia virus type I) binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Microvillus Coated Pit Cell Cortex Membrane Cytoplasmic Membrane-bounded Vesicle Unconventional Myosin Complex DNA-directed RNA Polymerase II, Holoenzyme Endocytic Vesicle Axon Clathrin-coated Vesicle Membrane Filamentous Actin Nuclear Membrane Ruffle Membrane Neuronal Cell Body Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity	Protein Binding Kinase Binding
	Biological Process	Protein Targeting Intracellular Protein Transport Endocytosis Synaptic Transmission Synapse Assembly Sensory Perception Of Sound Locomotory Behavior Metabolic Process Glutamate Secretion Dendrite Development Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Response To Drug Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Regulation Of Secretion Membrane Organization Cellular Response To Electrical Stimulus	Apoptotic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Negative Regulation Of Apoptotic Process Innate Immune Response
Pathways		Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System
Drugs
Diseases
GWAS		Hypertension ( 21626137)
Protein-Protein Interactions		17 interactors: ACTA1 AP2A1 APC CALCOCO2 CALM2 CDC42 DAB1 DAB2 DLG1 GIPC1 OPTN PAK1 PAK3 RNF11 TAX1BP1 TOM1 TOM1L2	40 interactors: ARHGAP1 CALCOCO2 CNTN2 COG7 CWF19L2 CXXC1 DAZAP2 DSTN EMILIN1 FAM168A FAM189A2 FOXC2 GABARAP IKBKG KIF5B LGALS8 LMO3 MAP1LC3B MAP1LC3C MRPL11 MRPL53 MYO6 NMRK1 ORC5 PLEKHN1 RAB18 RAD18 RIPK1 RNF11 SSX2 STARD13 TBC1D17 TCEA2 TNFAIP3 TNIP1 TNIP3 TRAF6 TSG101 TSHZ3 UBC
Entrez ID		4646	8887
HPRD ID		02985	05618
Ensembl ID		ENSG00000196586	ENSG00000106052
Uniprot IDs		Q9UM54	A4D196 B4DSG5 Q86VP1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction Immune System Process Positive Regulation Of Protein Kinase Activity Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Division Neuron Projection Development Positive Regulation Of Protein Metabolic Process Locomotion Regulation Of Signaling Positive Regulation Of Phosphorylation Cellular Localization Cell Development Axonogenesis Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Cellular Protein Localization Protein Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Neuron Projection Morphogenesis Cell Morphogenesis Positive Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Axon Guidance Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Stimulus Cell Projection Organization Negative Regulation Of Signaling Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Response To External Stimulus Cell Projection Morphogenesis Regulation Of Immune System Process Regulation Of Cell Cycle Process	Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling MyD88-independent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Organelle Disassembly Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleophagy Immune Response-regulating Signaling Pathway JNK Cascade Cellular Response To Stress Mitochondrion Degradation Regulation Of Vascular Wound Healing Regulation Of Type I Interferon Production Stress-activated MAPK Cascade Negative Regulation Of Intracellular Signal Transduction Stress-activated Protein Kinase Signaling Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Autophagic Vacuole Assembly Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Activation Of MAPK Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Macroautophagy Regulation Of Signaling I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Autophagy Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Protein Processing Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intracellular Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Membrane Organization
Tagcloud ?		109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 tom1 ubbd ubbddelta weakened	100nm 48h 81m anapc13 calm2 carcinogenic diarrheic drawing exhaustive explanation hn1 malat1 mapre2 mllt11 molluscs oa okadaic pathologies poisoning positives pttg1 rodents sga shellfish shsy5y ssh subtractive toxins tumourigenesis
Tagcloud (Difference) ?		109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 tom1 ubbd ubbddelta weakened	100nm 48h 81m anapc13 calm2 carcinogenic diarrheic drawing exhaustive explanation hn1 malat1 mapre2 mllt11 molluscs oa okadaic pathologies poisoning positives pttg1 rodents sga shellfish shsy5y ssh subtractive toxins tumourigenesis
Tagcloud (Intersection) ?