MYO6 and TOM1L2

Number of citations of the paper that reports this interaction (PMID 23023224)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		MYO6	TOM1L2
Gene Name		myosin VI	target of myb1-like 2 (chicken)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Microvillus Coated Pit Cell Cortex Membrane Cytoplasmic Membrane-bounded Vesicle Unconventional Myosin Complex DNA-directed RNA Polymerase II, Holoenzyme Endocytic Vesicle Axon Clathrin-coated Vesicle Membrane Filamentous Actin Nuclear Membrane Ruffle Membrane Neuronal Cell Body Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Intracellular Extracellular Vesicular Exosome
	Molecular Function	Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity	Protein Binding Protein Kinase Binding Clathrin Binding
	Biological Process	Protein Targeting Intracellular Protein Transport Endocytosis Synaptic Transmission Synapse Assembly Sensory Perception Of Sound Locomotory Behavior Metabolic Process Glutamate Secretion Dendrite Development Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Response To Drug Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Regulation Of Secretion Membrane Organization Cellular Response To Electrical Stimulus	Intracellular Protein Transport Signal Transduction Negative Regulation Of Mitotic Nuclear Division
Pathways		Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Hypertension ( 21626137)
Protein-Protein Interactions		17 interactors: ACTA1 AP2A1 APC CALCOCO2 CALM2 CDC42 DAB1 DAB2 DLG1 GIPC1 OPTN PAK1 PAK3 RNF11 TAX1BP1 TOM1 TOM1L2	6 interactors: APP LAPTM5 MYO6 NEDD4 RNF11 UBC
Entrez ID		4646	146691
HPRD ID		02985	18213
Ensembl ID		ENSG00000196586	ENSG00000175662
Uniprot IDs		Q9UM54	B7Z2L7 B7Z2U2 F5H3S6 Q6ZVM7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction Immune System Process Positive Regulation Of Protein Kinase Activity Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Division Neuron Projection Development Positive Regulation Of Protein Metabolic Process Locomotion Regulation Of Signaling Positive Regulation Of Phosphorylation Cellular Localization Cell Development Axonogenesis Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Cellular Protein Localization Protein Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Neuron Projection Morphogenesis Cell Morphogenesis Positive Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Axon Guidance Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Stimulus Cell Projection Organization Negative Regulation Of Signaling Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Response To External Stimulus Cell Projection Morphogenesis Regulation Of Immune System Process Regulation Of Cell Cycle Process	Synapse Organization Intracellular Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Neuromuscular Junction Development Regulation Of DNA-templated Transcription In Response To Stress Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Synapse Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Synapse Structure Or Activity Signal Transduction In Response To DNA Damage Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Modification By Small Protein Conjugation Protein Catabolic Process Signal Transduction By P53 Class Mediator Endocytosis Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Notch Signaling Pathway Dendrite Development Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Neuron Projection Development Protein Polyubiquitination Cellular Macromolecule Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Neuron Development Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Cellular Localization Regulation Of Cell Cycle Phase Transition Progesterone Receptor Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Locomotory Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 tom1 ubbd ubbddelta weakened	becomes degradative endosomes enlarged fyn gat gga hepatocyte intermediary like1 like2 localizes multivesicular mvb mvbs myb1 p85 possesses ptap sorting stam tagged tsg101 ubiquitinated vhs vps27p
Tagcloud (Difference) ?		109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 ubbd ubbddelta weakened	becomes degradative endosomes enlarged fyn gat gga hepatocyte intermediary like1 like2 localizes multivesicular mvb mvbs p85 possesses ptap sorting stam tagged tsg101 ubiquitinated vhs vps27p
Tagcloud (Intersection) ?		myb1 tom1