KMT2A and AVP

Number of citations of the paper that reports this interaction (PMID 14607844)
12

Data Source:
BioGRID (enzymatic study)

		KMT2A	AVP
Gene Name		lysine (K)-specific methyltransferase 2A	arginine vasopressin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Histone Methyltransferase Complex MLL1 Complex	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite
	Molecular Function	Core Promoter Sequence-specific DNA Binding AT DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Unmethylated CpG Binding Lysine-acetylated Histone Binding	Protein Kinase Activity Signal Transducer Activity Receptor Binding Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	DNA Methylation Chromatin Organization Transcription From RNA Polymerase II Promoter Protein Complex Assembly Apoptotic Process Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Positive Regulation Of Transporter Activity Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Histone H4-K16 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H3-K14 Acetylation Histone H3-K4 Trimethylation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cellular Response To Drug	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Generation Of Precursor Metabolites And Energy Protein Phosphorylation Water Transport Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Circadian Rhythm Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Testosterone Response To Nicotine Social Behavior Regulation Of Renal Sodium Excretion Vasoconstriction Hyperosmotic Salinity Response Maternal Behavior Negative Regulation Of Apoptotic Process Penile Erection Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Sodium-independent Organic Anion Transport Response To Ethanol Positive Regulation Of Vasoconstriction Negative Regulation Of Transmission Of Nerve Impulse Transmembrane Transport ERK1 And ERK2 Cascade Protein Kinase C Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Aquaporin-mediated transport SLC-mediated transmembrane transport Transport of organic anions G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Transport of vitamins, nucleosides, and related molecules BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ASH2L AVP BMI1 CBX4 CREBBP CTNNB1 CTR9 FASLG H3F3A HCFC1 HCFC2 HIST1H3A HIST1H4A HIST2H3C HIST3H3 INS KAT8 MEN1 MTM1 OXT PAF1 PLXNB1 PPIE PPP1R15A RBBP5 RNF2 SBF1 SET SVIL TAF9 TASP1 TOP1 WDR5	8 interactors: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR TXNDC17
Entrez ID		4297	551
HPRD ID		01162	01891
Ensembl ID		ENSG00000118058	ENSG00000101200
Uniprot IDs		Q03164	P01185
PDB IDs		2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Regulation Of Gene Expression Organelle Organization Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Gene Expression Methylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Peptidyl-amino Acid Modification Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Positive Regulation Of Cellular Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process DNA Methylation Protein Acetylation Cellular Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Histone H3-K4 Methylation DNA Modification Histone Ubiquitination Chromatin Silencing	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Vasoconstriction Regulation Of Vasoconstriction Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Blood Pressure Regulation Of Blood Pressure Telencephalon Development Sperm Ejaculation Blood Circulation Response To Hormone Positive Regulation Of Systemic Arterial Blood Pressure Forebrain Development Maternal Behavior Response To Peptide Insemination Positive Regulation Of Cytosolic Calcium Ion Concentration Copulation Regulation Of Renal Sodium Excretion Cellular Response To Hormone Stimulus Cytosolic Calcium Ion Homeostasis Regulation Of Excretion Response To Organic Substance Brain Development Social Behavior Head Development Organ Development Response To Organonitrogen Compound Cellular Calcium Ion Homeostasis Chemical Homeostasis Calcium Ion Homeostasis Activation Of Phospholipase C Activity Mating Cellular Response To Organic Substance Positive Regulation Of Phospholipase C Activity Central Nervous System Development Negative Regulation Of Transport Cellular Metal Ion Homeostasis Positive Regulation Of Phospholipase Activity Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cellular Response To Drug Cellular Ion Homeostasis Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Metal Ion Homeostasis Response To Steroid Hormone Cellular Chemical Homeostasis System Development Homeostatic Process Response To Estradiol
Tagcloud ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2b landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	arginine ascending bath ca2 camp car ctal fluxes henle hypotonic isotonic limb lumen medullary mg2 mmol mol mtal nacl net pdte perfusion phospholipase reabsorption segments sensing thick transepithelial vasopressin
Tagcloud (Difference) ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2b landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	arginine ascending bath ca2 camp car ctal fluxes henle hypotonic isotonic limb lumen medullary mg2 mmol mol mtal nacl net pdte perfusion phospholipase reabsorption segments sensing thick transepithelial vasopressin
Tagcloud (Intersection) ?