KMT2A and OXT

Number of citations of the paper that reports this interaction (PMID 14607844)
12

Data Source:
BioGRID (enzymatic study)

		KMT2A	OXT
Gene Name		lysine (K)-specific methyltransferase 2A	oxytocin/neurophysin I prepropeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Histone Methyltransferase Complex MLL1 Complex	Extracellular Region Extracellular Space Secretory Granule Terminal Bouton
	Molecular Function	Core Promoter Sequence-specific DNA Binding AT DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Unmethylated CpG Binding Lysine-acetylated Histone Binding	Neurohypophyseal Hormone Activity Oxytocin Receptor Binding
	Biological Process	DNA Methylation Chromatin Organization Transcription From RNA Polymerase II Promoter Protein Complex Assembly Apoptotic Process Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Positive Regulation Of Transporter Activity Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Histone H4-K16 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H3-K14 Acetylation Histone H3-K4 Trimethylation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cellular Response To Drug	Response To Amphetamine Regulation Of Heart Rate Maternal Aggressive Behavior Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Memory Grooming Behavior Response To Sucrose Positive Regulation Of Norepinephrine Secretion Response To Activity Sleep Response To Food Positive Regulation Of Prostaglandin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Prostaglandin E Social Behavior Negative Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Cocaine Hyperosmotic Salinity Response Maternal Behavior Sperm Ejaculation Eating Behavior Drinking Behavior Response To Peptide Hormone Response To Ether Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Female Receptivity Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To CAMP Response To Electrical Stimulus Regulation Of Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Male Mating Behavior Positive Regulation Of Penile Erection Positive Regulation Of Hindgut Contraction Negative Regulation Of Gastric Acid Secretion Positive Regulation Of Uterine Smooth Muscle Contraction
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Vasopressin-like receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Oxytocin
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ASH2L AVP BMI1 CBX4 CREBBP CTNNB1 CTR9 FASLG H3F3A HCFC1 HCFC2 HIST1H3A HIST1H4A HIST2H3C HIST3H3 INS KAT8 MEN1 MTM1 OXT PAF1 PLXNB1 PPIE PPP1R15A RBBP5 RNF2 SBF1 SET SVIL TAF9 TASP1 TOP1 WDR5	5 interactors: ESR2 KMT2A OXTR PREP TXNDC17
Entrez ID		4297	5020
HPRD ID		01162	08880
Ensembl ID		ENSG00000118058	ENSG00000101405
Uniprot IDs		Q03164	P01178
PDB IDs		2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Regulation Of Gene Expression Organelle Organization Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Gene Expression Methylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Peptidyl-amino Acid Modification Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Positive Regulation Of Cellular Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process DNA Methylation Protein Acetylation Cellular Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Histone H3-K4 Methylation DNA Modification Histone Ubiquitination Chromatin Silencing	Positive Regulation Of Cellular Response To Drug Response To Anoxia Positive Regulation Of Norepinephrine Secretion Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Negative Regulation Of Gastric Acid Secretion Regulation Of Response To Drug Epithelial Cell Maturation Involved In Prostate Gland Development Regulation Of Gastric Acid Secretion Regulation Of Systemic Arterial Blood Pressure By Vasopressin Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Penile Erection Sperm Ejaculation Maternal Process Involved In Parturition Rhythmic Process Regulation Of Penile Erection Positive Regulation Of Catecholamine Secretion Positive Regulation Of Uterine Smooth Muscle Contraction Regulation Of Norepinephrine Secretion Histone H3-K4 Trimethylation Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Synaptic Transmission, GABAergic Sleep Maternal Behavior Histone H4-K16 Acetylation Vagina Development Positive Regulation Of Histone H3-K4 Methylation Insemination Uterus Development ERK1 And ERK2 Cascade Parturition Intracellular Estrogen Receptor Signaling Pathway Epithelial Cell Differentiation Involved In Prostate Gland Development Response To Steroid Hormone Extracellular Negative Regulation Of Signal Transduction Gland Development Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Organic Substance Copulation Epithelial Cell Maturation Suckling Behavior Positive Regulation Of Synaptic Transmission, Glutamatergic Female Genitalia Development Regulation Of Cellular Component Organization Regulation Of Histone H3-K4 Methylation Negative Regulation Of Receptor Activity Positive Regulation Of Smooth Muscle Contraction Cellular Response To Hormone Stimulus Peptidyl-lysine Trimethylation
Tagcloud ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2b landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	altering anorexigenic arcuate basel broader dmnv fos hyperphagia hypothalamus icv immunoreactive intake intraperitoneal ip islets karger locomotor medulla nasal nts oxytocin paraventricular postrema potentiated pvn route solitary tolerance vagus
Tagcloud (Difference) ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet jarid1 jumonji kdm5a kmt2b landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	altering anorexigenic arcuate basel broader dmnv fos hyperphagia hypothalamus icv immunoreactive intake intraperitoneal ip karger locomotor medulla nasal nts oxytocin paraventricular postrema potentiated pvn route solitary tolerance vagus
Tagcloud (Intersection) ?		islets