MAP3K5 and MAP3K6

Number of citations of the paper that reports this interaction (PMID 17210579)
20

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MAP3K5	MAP3K6
Gene Name		mitogen-activated protein kinase kinase kinase 5	mitogen-activated protein kinase kinase kinase 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Protein Kinase Complex	Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase Binding Protein Homodimerization Activity	Magnesium Ion Binding MAP Kinase Kinase Kinase Activity ATP Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Response To Ischemia Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process JNK Cascade Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Viral Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Neuron Death Cellular Response To Reactive Nitrogen Species	Activation Of MAPKK Activity Protein Phosphorylation Signal Transduction Activation Of JUN Kinase Activity
Pathways		Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: AKT1 AKT2 ARRB1 ARRB2 CDC25A CDKN1A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 GADD45B GEMIN5 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L PDCD6 PPP3R1 PPP5C PTPN11 QARS RAF1 SFN TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TXN USP9X YWHAE YWHAH YWHAQ YWHAZ	1 interactors: MAP3K5
Entrez ID		4217	9064
HPRD ID		03904	05126
Ensembl ID		ENSG00000197442	ENSG00000142733
Uniprot IDs		Q99683	O95382
PDB IDs		2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Apoptotic Process Positive Regulation Of Transferase Activity Programmed Cell Death Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Cell Death Death Regulation Of MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Response To Stress Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Apoptotic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Stimulus Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Programmed Cell Death Signal Transduction Signaling Positive Regulation Of Cell Death	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Reactive Nitrogen Species Response To Ischemia Activation Of JUN Kinase Activity Programmed Necrotic Cell Death Necrotic Cell Death Cellular Response To Hydrogen Peroxide Activation Of MAPKK Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Death Regulation Of JUN Kinase Activity JNK Cascade Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Cellular Response To Reactive Oxygen Species Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Hydrogen Peroxide Positive Regulation Of Endopeptidase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Positive Regulation Of Peptidase Activity Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of MAP Kinase Activity MAPK Cascade Protein Processing Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Neuron Death Positive Regulation Of Proteolysis Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Response To Oxidative Stress Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Response To Inorganic Substance
Tagcloud ?		199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4
Tagcloud (Difference) ?		199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4
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