MAP3K5 and USP9X

Number of citations of the paper that reports this interaction (PMID 20005844)
12

Data Source:
BioGRID (enzymatic study)

		MAP3K5	USP9X
Gene Name		mitogen-activated protein kinase kinase kinase 5	ubiquitin specific peptidase 9, X-linked
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Protein Kinase Complex	Cytoplasm Cytosol Membrane Growth Cone Apical Part Of Cell
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase Binding Protein Homodimerization Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Co-SMAD Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Response To Ischemia Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process JNK Cascade Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Viral Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Neuron Death Cellular Response To Reactive Nitrogen Species	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Neuron Migration Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Chromosome Segregation Mitotic Nuclear Division Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Post-embryonic Development Gene Expression Protein Deubiquitination Cerebellar Cortex Structural Organization Hippocampus Development BMP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Axon Extension Cell Division Regulation Of Proteasomal Protein Catabolic Process
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: AKT1 AKT2 ARRB1 ARRB2 CDC25A CDKN1A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 GADD45B GEMIN5 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L PDCD6 PPP3R1 PPP5C PTPN11 QARS RAF1 SFN TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TXN USP9X YWHAE YWHAH YWHAQ YWHAZ	13 interactors: CTNNB1 DCX ERG GPSM1 MAP3K5 MCL1 MLLT4 PEX5 PSD4 SMAD2 SMAD4 SMURF1 UBC
Entrez ID		4217	8239
HPRD ID		03904	02091
Ensembl ID		ENSG00000197442	ENSG00000124486
Uniprot IDs		Q99683	Q6P468 Q86X58 Q93008
PDB IDs		2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Apoptotic Process Positive Regulation Of Transferase Activity Programmed Cell Death Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Cell Death Death Regulation Of MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Response To Stress Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Apoptotic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Stimulus Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Programmed Cell Death Signal Transduction Signaling Positive Regulation Of Cell Death	Regulation Of Cellular Response To Growth Factor Stimulus Cell Differentiation Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Signaling Pathway Embryonic Axis Specification Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Stem Cell Differentiation Response To Transforming Growth Factor Beta Regulation Of Epithelial To Mesenchymal Transition Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Endoderm Development Embryonic Pattern Specification Response To Growth Factor Regulation Of BMP Signaling Pathway Endothelium Development Cell Fate Commitment SMAD Protein Complex Assembly Intracellular Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Axis Specification Positive Regulation Of Signal Transduction Mesonephros Development Signal Transduction Embryonic Foregut Morphogenesis Foregut Morphogenesis Protein Localization To Cell Surface Dorsal/ventral Axis Specification Ectoderm Development Kidney Epithelium Development Stem Cell Maintenance Signaling Establishment Of Endothelial Barrier Regulation Of Heart Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Neuron Migration Cell Communication Transcription Initiation From RNA Polymerase II Promoter Gastrulation Regulation Of Cellular Process
Tagcloud ?		199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4	address adjuvant attenuation biomarker candidate causing define deubiquitinase differential downregulator driven elusive endocrine eralpha experiencing fulvestrant luminal prevented problem receive responsive rnai screen signature stabilize sufficient tamoxifen widely zr
Tagcloud (Difference) ?		199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4	address adjuvant attenuation biomarker candidate causing define deubiquitinase differential downregulator driven elusive endocrine eralpha experiencing fulvestrant luminal prevented problem receive responsive rnai screen signature stabilize sufficient tamoxifen widely zr
Tagcloud (Intersection) ?