MARK3 and PNPLA2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MARK3	PNPLA2
Gene Name		MAP/microtubule affinity-regulating kinase 3	patatin-like phospholipase domain containing 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Lipid Particle Cytosol Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Triglyceride Lipase Activity
	Biological Process	Protein Phosphorylation	Phospholipid Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Particle Organization Acylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways			Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		27 interactors: ANKRD7 ASB13 ATP6V0C CDC25C CHGB CPSF4 DYNLL1 FANCF HDAC7 KSR1 MAP2 MAPT MITF NOL11 PIM1 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ	10 interactors: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		4140	57104
HPRD ID		04058	11443
Ensembl ID		ENSG00000075413	ENSG00000177666
Uniprot IDs		P27448 Q86U11	Q96AD5
PDB IDs		2QNJ 3FE3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Apoptotic Process Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Programmed Cell Death Cell Death Death Organelle Organization Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Apoptotic Process Positive Regulation Of Transport Regulation Of Cellular Component Organization Regulation Of Cell Death Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Apoptotic Process Multicellular Organismal Development Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death System Development Intracellular Signal Transduction Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Substantia Nigra Development Protein Targeting Regulation Of Protein Localization Developmental Process Cellular Response To Insulin Stimulus Neural Nucleus Development Signaling Anatomical Structure Development Regulation Of Phosphorylation Protein Targeting To Mitochondrion Regulation Of Cellular Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Intracellular Protein Transport Cell Communication Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Activation	Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Post-Golgi Vesicle-mediated Transport Cellular Response To Cobalt Ion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Catalytic Activity Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Triglyceride Catabolic Process Regulation Of GTPase Activity Mullerian Duct Regression Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Receptor Recycling Response To Cobalt Ion Golgi Vesicle Transport Short-term Memory COPI-coated Vesicle Budding Positive Regulation Of Lipoprotein Lipase Activity COPI Coating Of Golgi Vesicle Positive Regulation Of Metabolic Process
Tagcloud ?		acrylamide amiloride bbmv benzoyl border brush cariporide dihydro guanidine guanidino hnhe1 ic50 isopro isopropyl lap1 methane methylsulphonyl micromol nhe nhe1 nhe2 nhe3 ok opossum propenyl pylidene rbnhe2 s3226 sulphonate	abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Difference) ?		acrylamide amiloride bbmv benzoyl border brush cariporide dihydro guanidine guanidino hnhe1 ic50 isopro isopropyl lap1 methane methylsulphonyl micromol nhe nhe1 nhe2 nhe3 ok opossum propenyl pylidene rbnhe2 s3226 sulphonate	abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Intersection) ?