MAPT and STXBP1

Number of citations of the paper that reports this interaction (PMID 12963086)
9

Data Source:
HPRD (in vivo)

		MAPT	STXBP1
Gene Name		microtubule-associated protein tau	syntaxin binding protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Axon Growth Cone Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Tubulin Complex	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Platelet Alpha Granule Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Apolipoprotein Binding Lipoprotein Particle Binding	SNARE Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Poly(A) RNA Binding Protein N-terminus Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Adult Walking Behavior Axon Cargo Transport Regulation Of Autophagy Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of Intracellular Transport Positive Regulation Of Axon Extension Mitochondrion Transport Along Microtubule Axon Extension Generation Of Neurons Regulation Of Microtubule-based Movement	Platelet Degranulation Energy Reserve Metabolic Process Vesicle Docking Involved In Exocytosis Synaptic Transmission Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Protein Transport Synaptic Vesicle Maturation Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of SNARE Complex Assembly Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Insulin Secretion Protein Stabilization Long Term Synaptic Depression Platelet Aggregation Protein Localization To Plasma Membrane
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins	Integration of energy metabolism Regulation of insulin secretion
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Head circumference (infant) ( 22504419) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Parkinson's disease ( 20711177 21292315 19915575 22438815 20070850 21044948 21738487) Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		78 interactors: AATF ABL1 ACTB AKT1 APOE APP ARHGEF40 BAG1 CALM1 CAMK2A CAPN2 CASP1 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CSNK1A1 CSNK1D CSNK2A1 EP300 FYN GSK3A GSK3B HSPA4 HSPA8 LRRK2 MAPK11 MAPK12 MAPK13 MAPK8 MARCH7 MARK1 MARK2 MARK3 MARK4 OGT PEG10 PHKG1 PIN1 PKN1 PPP2CA PPP2CB PPP2R4 PPP2R5A PPP5C PRKACA PRKAR1A PRKCD PSEN1 PTK2B RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SGK1 SIRT1 SNCA SPTB SRC STAU1 STUB1 STXBP1 SYK TRAF6 TUBA1B TUBA4A TUBB UBB UBC UBE2D2 USP9Y YWHAB YWHAZ	27 interactors: APBA1 APBA2 APP CDK5 CDK5R1 DOC2A DOC2B DYT10 HGS MAPT NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SQSTM1 STX11 STX19 STX1A STX1B STX2 STX3 SYTL4 TRIM38 USO1
Entrez ID		4137	6812
HPRD ID		01142	04235
Ensembl ID		ENSG00000186868	ENSG00000136854
Uniprot IDs		B3KTM0 P10636	B7Z1V5 P61764 Q68CM6
PDB IDs		1I8H 3FQP 3OVL 4GLR
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Death Apoptotic Process Death Programmed Cell Death Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin Signaling Pathway Protein Metabolic Process Response To Growth Factor Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Positive Regulation Of Cell Death Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Intracellular Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Regulation Of Cellular Component Organization Regulation Of Protein Phosphorylation Cellular Response To Stimulus Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Immune Response Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Phosphorylation Signal Transduction Regulation Of Proteolysis Regulation Of Signal Transduction	Synaptic Transmission Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Neurotransmitter Secretion Synaptic Vesicle Transport Cell-cell Signaling Regulation Of Neurotransmitter Levels Establishment Of Localization In Cell Secretion By Cell Neurotransmitter Transport Vesicle Fusion Establishment Of Vesicle Localization Vesicle Localization Secretion Establishment Of Organelle Localization Cellular Localization Exocytosis Organelle Fusion Vesicle Docking Intracellular Transport Membrane Docking Organelle Localization Membrane Fusion Protein Localization Regulation Of Exocytosis Regulation Of Cellular Localization Protein Transport Membrane Organization Establishment Of Protein Localization Intracellular Protein Transport Signaling Transport Cell Communication Vesicle Organization Positive Regulation Of Exocytosis Vesicle-mediated Transport Cellular Protein Localization Regulation Of Vesicle-mediated Transport Peptidyl-threonine Phosphorylation Regulation Of Secretion Axon Cargo Transport Regulation Of Signaling Organelle Organization Positive Regulation Of Secretion Histone H3-T6 Phosphorylation Neurofilament Bundle Assembly Positive Regulation Of Transport Serine Phosphorylation Of STAT3 Protein Nervous System Development Regulation Of Synaptic Vesicle Transport
Tagcloud ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants	16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Difference) ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants	16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Intersection) ?