MAPT and APOE

Number of citations of the paper that reports this interaction (PMID 7566652)
6

Data Source:
BioGRID (pull down, unspecified method)
HPRD (in vivo, in vitro)

		MAPT	APOE
Gene Name		microtubule-associated protein tau	apolipoprotein E
Image
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Axon Growth Cone Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Tubulin Complex	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Cytoplasm Lysosome Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Microtubule Plasma Membrane Membrane Dendrite Extracellular Matrix Extrinsic Component Of External Side Of Plasma Membrane Vesicle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Chylomicron Neuronal Cell Body Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Apolipoprotein Binding Lipoprotein Particle Binding	Beta-amyloid Binding Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Cholesterol Binding Antioxidant Activity Cholesterol Transporter Activity Identical Protein Binding Protein Homodimerization Activity Hydroxyapatite Binding Metal Chelating Activity Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Very-low-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Adult Walking Behavior Axon Cargo Transport Regulation Of Autophagy Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of Intracellular Transport Positive Regulation Of Axon Extension Mitochondrion Transport Along Microtubule Axon Extension Generation Of Neurons Regulation Of Microtubule-based Movement	Response To Reactive Oxygen Species Retinoid Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Response To Dietary Excess Triglyceride Metabolic Process Cholesterol Catabolic Process Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Cytoskeleton Organization G-protein Coupled Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction Synaptic Transmission, Cholinergic Aging Phototransduction, Visible Light Cholesterol Metabolic Process Regulation Of Gene Expression Negative Regulation Of Platelet Activation Positive Regulation Of Cholesterol Esterification Positive Regulation Of Cholesterol Efflux Peripheral Nervous System Axon Regeneration Long-chain Fatty Acid Transport Protein Import Triglyceride Catabolic Process CGMP-mediated Signaling Negative Regulation Of Blood Coagulation Regulation Of Axon Extension Positive Regulation Of CGMP Biosynthetic Process Neuron Projection Regeneration Regulation Of Cdc42 Protein Signal Transduction Response To Retinoic Acid Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Insulin Cholesterol Efflux Phospholipid Efflux Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Vasodilation Cholesterol Homeostasis Negative Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Reverse Cholesterol Transport Small Molecule Metabolic Process Response To Ethanol Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Axon Extension Positive Regulation Of Lipid Biosynthetic Process Intracellular Transport Regulation Of Neuronal Synaptic Plasticity Oligodendrocyte Differentiation Artery Morphogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Lipid Biosynthetic Process Maintenance Of Location In Cell Fatty Acid Homeostasis Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Development Cellular Response To Interleukin-1 Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Negative Regulation Of Cholesterol Efflux Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering N-methyl-D-aspartate Receptor Clustering Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Negative Regulation Of Neuron Death Positive Regulation Of Neuron Death Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Beta-amyloid Formation Regulation Of Tau-protein Kinase Activity Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dendritic Spine Maintenance Positive Regulation Of Phospholipid Efflux Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins	Lipoprotein metabolism Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction HDL-mediated lipid transport Visual phototransduction Scavenging by Class A Receptors Retinoid metabolism and transport
Drugs			Human Serum Albumin Serum albumin iodonated
Diseases
GWAS		Bone mineral density ( 22504420) Head circumference (infant) ( 22504419) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Parkinson's disease ( 20711177 21292315 19915575 22438815 20070850 21044948 21738487) Progressive supranuclear palsy ( 21685912)	Age-related macular degeneration ( 23326517 23455636) Alzheimer's disease ( 17975299 22832961 20460622 17998437 18823527 19734902 19734903 21627779 19125160 20061627 22245343) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 17474819 20885792 23565137) Alzheimer's disease biomarkers ( 23562540 21123754 23419831) Apolipoprotein Levels ( 23031429) Brain imaging ( 20100581) C-reactive protein ( 19567438 18439548 18439552) Cardiovascular disease risk factors ( 20838585) Cholesterol, total ( 19060911 20686565) Cognitive decline ( 22054870) HDL cholesterol ( 21909109 19060911 20686565) Hippocampal atrophy ( 22745009) LDL cholesterol ( 23726366 18802019 18193043 18193044 20864672 19060906 19060911 23067351 20686565) Lipid metabolism phenotypes ( 22286219) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Longevity ( 21418511) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) Quantitative traits ( 19197348) Response to statin therapy (LDL-C) ( 22331829) Triglycerides ( 19060911 20686565)
Protein-Protein Interactions		78 interactors: AATF ABL1 ACTB AKT1 APOE APP ARHGEF40 BAG1 CALM1 CAMK2A CAPN2 CASP1 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CSNK1A1 CSNK1D CSNK2A1 EP300 FYN GSK3A GSK3B HSPA4 HSPA8 LRRK2 MAPK11 MAPK12 MAPK13 MAPK8 MARCH7 MARK1 MARK2 MARK3 MARK4 OGT PEG10 PHKG1 PIN1 PKN1 PPP2CA PPP2CB PPP2R4 PPP2R5A PPP5C PRKACA PRKAR1A PRKCD PSEN1 PTK2B RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SGK1 SIRT1 SNCA SPTB SRC STAU1 STUB1 STXBP1 SYK TRAF6 TUBA1B TUBA4A TUBB UBB UBC UBE2D2 USP9Y YWHAB YWHAZ	54 interactors: A2M ACTG1 ALB ANKH APP ARFGAP1 C19orf52 CDC37 CNTF CSNK2A1 CTSB CYP2C18 CYP2C8 ECSIT ELAVL1 EPN2 FARSA FBXL12 FOXG1 FXYD7 GCDH HTRA1 IFIT3 IFIT5 IQSEC1 LCAT LDLR LONP1 LOXL4 LRP1 LRP2 LRP8 MAP2 MAPT MAST1 MID1IP1 NEFM NOS3 PCMT1 PDCD4 PLEKHA6 PLTP PRAM1 PRDX2 PRNP PSEN1 RHEB RNF32 RPL4 SCARB1 ST13 TYRO3 VLDLR ZNF558
Entrez ID		4137	348
HPRD ID		01142	00135
Ensembl ID		ENSG00000186868	ENSG00000130203
Uniprot IDs		B3KTM0 P10636	P02649
PDB IDs		1I8H 3FQP 3OVL 4GLR	1B68 1BZ4 1EA8 1GS9 1H7I 1LE2 1LE4 1LPE 1NFN 1NFO 1OEF 1OEG 1OR2 1OR3 2KC3 2KNY 2L7B
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Death Apoptotic Process Death Programmed Cell Death Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin Signaling Pathway Protein Metabolic Process Response To Growth Factor Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Positive Regulation Of Cell Death Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Intracellular Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Regulation Of Cellular Component Organization Regulation Of Protein Phosphorylation Cellular Response To Stimulus Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Immune Response Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Phosphorylation Signal Transduction Regulation Of Proteolysis Regulation Of Signal Transduction	Endocytosis Steroid Metabolic Process Vesicle-mediated Transport Cholesterol Metabolic Process Lipid Metabolic Process Sterol Metabolic Process Receptor-mediated Endocytosis Developmental Process Response To External Stimulus Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Alcohol Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Catalytic Activity Negative Regulation Of Apoptotic Process Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Programmed Cell Death Anatomical Structure Morphogenesis Cellular Response To Stimulus Multicellular Organismal Development Phototransduction, Visible Light Blood Coagulation Retinoid Metabolic Process Negative Regulation Of Cell Death Hemostasis Regulation Of Cellular Protein Metabolic Process Wound Healing Negative Regulation Of Neuron Apoptotic Process Lipoprotein Metabolic Process System Development Diterpenoid Metabolic Process Regulation Of Phosphorus Metabolic Process Anatomical Structure Development Lipid Transport Detection Of Visible Light Nervous System Development Apoptotic Cell Clearance Transport Phototransduction Small Molecule Metabolic Process Platelet Activation Lipid Localization Generation Of Neurons Plasma Lipoprotein Particle Clearance Negative Regulation Of Neuron Death Detection Of Light Stimulus Response To Wounding Reelin-mediated Signaling Pathway
Tagcloud ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants	aa adenovirus agreement amyloid amyloids apoe3 apoe4 apoj apolipoprotein apolipoproteins appear cerebral characterize deficient define deposition deposits fibril fibrillogenesis fibrils fragment greatest heterozygous injected lacking lipoproteins promoting restored utilized
Tagcloud (Difference) ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants	aa adenovirus agreement amyloid amyloids apoe3 apoe4 apoj apolipoprotein apolipoproteins appear cerebral characterize deficient define deposition deposits fibril fibrillogenesis fibrils fragment greatest heterozygous injected lacking lipoproteins promoting restored utilized
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