ITPR1 and CCNB1

Number of citations of the paper that reports this interaction (PMID 16237118)
8

Data Source:
HPRD (in vitro)

		ITPR1	CCNB1
Gene Name		inositol 1,4,5-trisphosphate receptor, type 1	cyclin B1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane	Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane
	Molecular Function	Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding	Patched Binding Protein Binding Protein Kinase Binding Histone Kinase Activity
	Biological Process	Response To Hypoxia Energy Reserve Metabolic Process Calcium Ion Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Protein Complex Assembly Mitotic Nuclear Envelope Disassembly Mitotic Metaphase Plate Congression Spermatogenesis Response To Mechanical Stimulus Negative Regulation Of Gene Expression Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone Phosphorylation Tissue Regeneration Response To Drug Mitotic Spindle Stabilization Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Histone H3-S10 Phosphorylation Involved In Chromosome Condensation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Phospholipase C-mediated cascade Signaling by FGFR in disease Integration of energy metabolism cGMP effects Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Nitric oxide stimulates guanylate cyclase Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by FGFR Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization	Phosphorylation of the APC/C MASTL Facilitates Mitotic Progression Mitotic Prometaphase G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown G2/M Transition Phosphorylation of Emi1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition M Phase Cyclin A/B1 associated events during G2/M transition G1/S Transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Mitotic G1-G1/S phases Recruitment of mitotic centrosome proteins and complexes G2/M DNA replication checkpoint Condensation of Prometaphase Chromosomes E2F mediated regulation of DNA replication G2/M DNA damage checkpoint Depolymerisation of the Nuclear Lamina Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic APC/C:Cdc20 mediated degradation of Cyclin B Resolution of Sister Chromatid Cohesion E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints Centrosome maturation Condensation of Prophase Chromosomes Mitotic G2-G2/M phases Polo-like kinase mediated events
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378) Breast cancer ( 23535729) Obesity-related traits ( 23251661)
Protein-Protein Interactions		29 interactors: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 ITPR3 ITPRIP LYN MRVI1 PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4	54 interactors: ANAPC11 ARID4A BRCA1 CCNB1IP1 CCNF CDC20 CDC25A CDC25C CDC27 CDC6 CDK1 CDK7 CDKN1A CDKN1B CDT1 CKS2 EP300 FLNA FZR1 GADD45A GADD45B GADD45G HERC5 HIST1H1A HIST1H1B ITPR1 KAT5 MAP4 MEF2C MOK PBK PCNA PIN1 PKMYT1 PLK1 POLA1 PRC1 PSMD4 PTCH1 PTMA RAD23A RALBP1 RB1 RPA1 RUNX2 SQSTM1 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 UBE2D2 UBE3D UBQLN1
Entrez ID		3708	891
HPRD ID		00925	00454
Ensembl ID		ENSG00000150995	ENSG00000134057
Uniprot IDs		B4DER3 B4DGH1 Q14643 Q59H91	P14635 Q5TZP9
PDB IDs			2B9R 2JGZ
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Regulation Of Ion Transport Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Protein Localization Blood Coagulation Hemostasis Regulation Of Cellular Localization Wound Healing Platelet Activation Cell Activation Regulation Of Transmembrane Transporter Activity Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Response To Organonitrogen Compound Regulation Of Intracellular Transport Signaling Regulation Of Platelet Aggregation Cell Communication Response To Organic Substance Response To Organic Cyclic Compound Response To Metal Ion Cellular Response To Stimulus Signal Transduction Neurotrophin TRK Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Transport Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Intracellular Signal Transduction Response To Stimulus Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Platelet Activation Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Cell Activation Regulation Of Establishment Of Protein Localization Response To Inorganic Substance Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor	Cell Cycle Process Regulation Of Cell Cycle Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Cell Cycle Checkpoint Regulation Of Kinase Activity Regulation Of Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Positive Regulation Of Protein Modification Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Cell Division Organelle Organization Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Protein Catabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition
Tagcloud ?		autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley	5q13 bacs bacterium chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular naip p1s pathogenicity pneumophila recessively simpler sma smas smn subcloning syntenic uncharacterized yac
Tagcloud (Difference) ?		autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley	5q13 bacs bacterium chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular naip p1s pathogenicity pneumophila recessively simpler sma smas smn subcloning syntenic uncharacterized yac
Tagcloud (Intersection) ?