ITPR1 and BANK1

Number of citations of the paper that reports this interaction (PMID 11782428)
41

Data Source:
HPRD (in vivo)

		ITPR1	BANK1
Gene Name		inositol 1,4,5-trisphosphate receptor, type 1	B-cell scaffold protein with ankyrin repeats 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane
	Molecular Function	Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding
	Biological Process	Response To Hypoxia Energy Reserve Metabolic Process Calcium Ion Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport	B Cell Activation Positive Regulation Of MAPK Cascade Negative Regulation Of Translational Initiation Negative Regulation Of B Cell Activation Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Interleukin-6 Secretion
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Phospholipase C-mediated cascade Signaling by FGFR in disease Integration of energy metabolism cGMP effects Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Nitric oxide stimulates guanylate cyclase Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by FGFR Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378) Breast cancer ( 23535729) Obesity-related traits ( 23251661)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 22763476) Systemic lupus erythematosus ( 18204447 23273568)
Protein-Protein Interactions		29 interactors: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 ITPR3 ITPRIP LYN MRVI1 PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4	3 interactors: ITPR1 ITPR2 LYN
Entrez ID		3708	55024
HPRD ID		00925	09819
Ensembl ID		ENSG00000150995	ENSG00000153064
Uniprot IDs		B4DER3 B4DGH1 Q14643 Q59H91	Q8NDB2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Regulation Of Ion Transport Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Protein Localization Blood Coagulation Hemostasis Regulation Of Cellular Localization Wound Healing Platelet Activation Cell Activation Regulation Of Transmembrane Transporter Activity Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Response To Organonitrogen Compound Regulation Of Intracellular Transport Signaling Regulation Of Platelet Aggregation Cell Communication Response To Organic Substance Response To Organic Cyclic Compound Response To Metal Ion Cellular Response To Stimulus Signal Transduction Neurotrophin TRK Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Transport Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Intracellular Signal Transduction Response To Stimulus Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Platelet Activation Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Cell Activation Regulation Of Establishment Of Protein Localization Response To Inorganic Substance Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Platelet Activation Fc-epsilon Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Secretion Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Activation Of Phospholipase C Activity Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase C Activity Wound Healing Regulation Of Protein Transport Positive Regulation Of Immune Response Regulation Of Secretion Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Cell Activation Response To Wounding Positive Regulation Of Phospholipase Activity Regulation Of Protein Localization Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Innate Immune Response Regulation Of Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Cellular Localization Energy Reserve Metabolic Process Response To Abiotic Stimulus Second-messenger-mediated Signaling Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Cation Transport Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Fibroblast Growth Factor Stimulus
Tagcloud ?		autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley	4e adaptor affecting affects agonist bp1 cd40 contains cpg eif4e establish implying initiation jnk mk2 mnk1 mtor p38 phospho putative secretion splenic stimulation stronger tlr9 toll translation unrecognized weak
Tagcloud (Difference) ?		autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley	4e adaptor affecting affects agonist bp1 cd40 contains cpg eif4e establish implying initiation jnk mk2 mnk1 mtor p38 phospho putative secretion splenic stimulation stronger tlr9 toll translation unrecognized weak
Tagcloud (Intersection) ?