IRS1 and PRKCG

Number of citations of the paper that reports this interaction (PMID 15364919)
42

Data Source:
HPRD (in vitro)

		IRS1	PRKCG
Gene Name		insulin receptor substrate 1	protein kinase C, gamma
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Insulin Receptor Complex Caveola Ciliary Basal Body Intracellular Membrane-bounded Organelle	Nucleus Cytosol Plasma Membrane Cell-cell Junction Dendrite Perinuclear Region Of Cytoplasm Synaptic Membrane
	Molecular Function	Signal Transducer Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Kinase C Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding SH2 Domain Binding Phosphatidylinositol 3-kinase Binding	Protein Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Serine/threonine/tyrosine Kinase Activity ATP Binding Zinc Ion Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Signaling Lipid Catabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of Fatty Acid Beta-oxidation Response To Insulin Cellular Response To Insulin Stimulus Protein Localization To Nucleus Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Response To Peptide Hormone Protein Kinase B Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Glucose Import In Response To Insulin Stimulus	Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Learning Or Memory Chemosensory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Phosphorylation Platelet Activation Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Response To Pain Rhythmic Process Innervation Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Signaling by GPCR Ca-dependent events CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAP12 signaling Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Downstream signal transduction Calmodulin induced events WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Transmission across Chemical Synapses Trafficking of GluR2-containing AMPA receptors DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Disinhibition of SNARE formation Innate Immune System Signalling by NGF PLC beta mediated events Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Trafficking of AMPA receptors Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling PLC-gamma1 signalling Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Drugs		[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
Diseases
GWAS		Adiponectin levels ( 22479202) Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 20686565) Triglycerides ( 20686565) Type 2 diabetes ( 20581827) Type 2 diabetes and other traits ( 19734900) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ	58 interactors: ADRBK1 AFAP1 ANXA7 APP ARHGEF25 CASR CCHCR1 CD5 CDC42 CHAT CYTH2 DAB2 DDX58 DVL2 EIF4E EPHB1 EXOC5 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MARK4 NFE2L2 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 SCN3A SDC2 STXBP1 TIAM1 TOP2A TRIM5 VTN YWHAB YWHAE YWHAG
Entrez ID		3667	5582
HPRD ID		00943	01502
Ensembl ID		ENSG00000169047	ENSG00000126583
Uniprot IDs		P35568	F5H5C4 P05129
PDB IDs		1IRS 1K3A 1QQG 2Z8C	2E73 2UZP
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Organic Substance Cellular Response To Organic Substance Response To Organonitrogen Compound Signal Transduction Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Response To Peptide Hormone Cell Communication Cellular Response To Hormone Stimulus Insulin Receptor Signaling Pathway Response To Peptide Cellular Response To Stimulus Response To Hormone Regulation Of Signaling Regulation Of Immune Response Positive Regulation Of Signal Transduction Cellular Response To Insulin Stimulus Innate Immune Response Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Immune System Process Immune Response Response To Stimulus Response To Insulin Defense Response Regulation Of Phosphorus Metabolic Process Response To Stress Immune System Process Fc Receptor Signaling Pathway Blood Coagulation Hemostasis Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Phosphorylation Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Response To Wounding Regulation Of Protein Phosphorylation	Regulation Of Signaling Regulation Of Cellular Process Signaling Nervous System Development Cell Communication Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Developmental Process Anatomical Structure Development Generation Of Neurons System Development Neuron Development Neuron Projection Development Neurogenesis Signal Transduction Positive Regulation Of Transport Regulation Of Cellular Component Organization Cell Differentiation Response To Stimulus Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Regulation Of Signal Transduction Cell Projection Organization Cellular Response To Stimulus Axon Development Glutamate Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Response To Stress Cell-cell Signaling Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Catalytic Activity Cell Projection Morphogenesis Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Metabolic Process Cell Part Morphogenesis Ephrin Receptor Signaling Pathway Regulation Of Cellular Localization Cell Morphogenesis Regulation Of Synaptic Plasticity Axon Guidance Positive Regulation Of Catalytic Activity Neuron-neuron Synaptic Transmission Transport Regulation Of Cell Development
Tagcloud ?		action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent gh initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist tyrosine wortmannin	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd psg1 pw39 tnnt1
Tagcloud (Difference) ?		action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent gh initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist tyrosine wortmannin	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd psg1 pw39 tnnt1
Tagcloud (Intersection) ?