IRS1 and PIK3R2

  • Number of citations of the paper that reports this interaction (PMID 12730242)
  • 15
  • Data Source:
  • HPRD (two hybrid, in vivo)

IRS1

PIK3R2

Gene Name insulin receptor substrate 1 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ 51 interactors: APP ARRB1 AXL CBL CD28 CRKL CSF1 CSF1R DYDC1 EGF EGFR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LTBP3 MRFAP1L1 PDGFRB PIK3CD RINT1 SEPT2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB
Entrez ID 3667 5296
HPRD ID 00943 04404
Ensembl ID ENSG00000169047 ENSG00000105647
Uniprot IDs P35568 O00459
PDB IDs 1IRS 1K3A 1QQG 2Z8C 2KT1 2XS6 3MTT 3O5Z
Enriched GO Terms of Interacting Partners?
Tagcloud ?
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kda  kinase  phosphatidylinositol  phosphorylated  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  tyrosine  wortmannin 
acetylated  acetylations  chip  contrary  deacetylase  deacetylases  distally  dysregulated  encompassing  facilitates  featured  h2a  h3k9  hexokinase  hk2  irs2  l6  lysines  myotubes  p85beta  pharmacologically  responsive  reverted  template  treatable  trichostatin  tsa  tss  z 
Tagcloud (Difference) ?
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kda  kinase  phosphatidylinositol  phosphorylated  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  tyrosine  wortmannin 
acetylated  acetylations  chip  contrary  deacetylase  deacetylases  distally  dysregulated  encompassing  facilitates  featured  h2a  h3k9  hexokinase  hk2  irs2  l6  lysines  myotubes  p85beta  pharmacologically  responsive  reverted  template  treatable  trichostatin  tsa  tss  z 
Tagcloud (Intersection) ?