MSL1 and CRKL

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		MSL1	CRKL
Gene Name		male-specific lethal 1 homolog (Drosophila)	v-crk avian sarcoma virus CT10 oncogene homolog-like
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm MSL Complex	Endosome Cytosol Extracellular Vesicular Exosome
	Molecular Function		Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Chromatin Organization Histone H4-K16 Acetylation	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CRKL FCHSD2 HIST2H2BE HORMAD1 KAT8 KPNB1 MORF4L1 MRGBP NUPR1 PAF1 PPM1G RAN RNF20 RNF40 SMARCC1 SNW1 UBE2D3	71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1
Entrez ID		339287	1399
HPRD ID		19425	03596
Ensembl ID		ENSG00000188895	ENSG00000099942
Uniprot IDs		B3KWR7 J3KSZ8 Q68DK7	P46109
PDB IDs		4B7Y 4B86 4DNC	2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Protein Monoubiquitination Histone H2B Ubiquitination Chromatin Modification Histone Monoubiquitination Histone Ubiquitination Histone Modification Organelle Organization Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Protein Acetylation Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Import Intracellular Transport Of Virus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Histone Methylation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein Ubiquitination RNA Metabolic Process Cellular Protein Modification Process Regulation Of Histone Methylation Histone H4 Acetylation Protein Modification By Small Protein Conjugation Regulation Of Homologous Chromosome Segregation Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Histone Modification Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Meiotic Recombination Checkpoint Positive Regulation Of Vitamin D Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process
Tagcloud ?		alters aspect comprise correlating cryptic exonic h2b h2bk123ub1 h3k36me3 htb intragenic intron intronic introns k123r lea1 lethality marks monoubiquitylation orfs packaging postulated saccharomyces snrnp splicing talk transcribed trimethylation u2	actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Difference) ?		alters aspect comprise correlating cryptic exonic h2b h2bk123ub1 h3k36me3 htb intragenic intron intronic introns k123r lea1 lethality marks monoubiquitylation orfs packaging postulated saccharomyces snrnp splicing talk transcribed trimethylation u2	actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Intersection) ?