HSPA1A and DYX1C1

Number of citations of the paper that reports this interaction (PMID 15189447)
22

Data Source:
HPRD (in vivo)

		HSPA1A	DYX1C1
Gene Name		heat shock 70kDa protein 1A	dyslexia susceptibility 1 candidate 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centriole Cytosol Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Ribonucleoprotein Complex Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Virus Receptor Activity G-protein Coupled Receptor Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Poly(A) RNA Binding Protein N-terminus Binding Unfolded Protein Binding	Protein Binding Estrogen Receptor Binding
	Biological Process	MRNA Catabolic Process Response To Unfolded Protein Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Protein Ubiquitination Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Protein Stabilization Negative Regulation Of Cell Death Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Neuron Migration Cilium Movement Determination Of Left/right Symmetry Regulation Of Intracellular Estrogen Receptor Signaling Pathway Outer Dynein Arm Assembly Inner Dynein Arm Assembly Regulation Of Proteasomal Protein Catabolic Process
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Viral RNP Complexes in the Host Cell Nucleus Attenuation phase Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA Influenza Infection Influenza Life Cycle HSF1-dependent transactivation Export of Viral Ribonucleoproteins from Nucleus
Drugs
Diseases
GWAS
Protein-Protein Interactions		79 interactors: AIFM1 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJC3 DNAJC7 DYX1C1 EGFR EIF2AK2 FANCC FOS GPR37 GRIN1 GRIN2D HCFC1 HIVEP1 HMGA1 HSBP1 HSF1 HSP90AA1 HSPA8 HSPBP1 IKBKG KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 PEX5 PLG POT1 PPP1R15A PRKCA PTGES3 PTMA RAP1A RAPGEF2 RHOA SAE1 SLC5A1 SNCA SNCB SNRK SOX9 ST13 STIP1 STUB1 TCERG1 TGM2 TOMM70A TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 YWHAB YWHAG YWHAQ YWHAZ	4 interactors: HSPA1A KDM1A SPDL1 STUB1
Entrez ID		3303	161582
HPRD ID		00774	10568
Ensembl ID		ENSG00000204389	ENSG00000256061
Uniprot IDs		A8K5I0 B3KTT5 P08107	Q8WXU2
PDB IDs		1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4J8F
Enriched GO Terms of Interacting Partners?		Protein Refolding Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Protein Folding Chaperone Cofactor-dependent Protein Refolding Response To Organic Substance Cellular Response To Stimulus Response To Stress Signaling Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Cell Communication Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Signal Transduction Regulation Of Cellular Component Organization Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Negative Regulation Of Biosynthetic Process Apoptotic Signaling Pathway Apoptotic Process	Positive Regulation Of Erythrocyte Differentiation Regulation Of Hormone Metabolic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Protein Binding Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Binding Regulation Of Primitive Erythrocyte Differentiation Response To Unfolded Protein Regulation Of Protein Binding Positive Regulation Of Chaperone-mediated Protein Complex Assembly Cellular Heat Acclimation Regulation Of Myeloid Cell Differentiation Negative Regulation Of Signal Transduction Regulation Of Protein Ubiquitination Negative Regulation Of Signaling Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Binding Ubiquitin-dependent SMAD Protein Catabolic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Protein Localization To Kinetochore Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Inclusion Body Assembly Protein Localization To Chromosome, Centromeric Region Positive Regulation Of Hormone Biosynthetic Process Regulation Of Glucocorticoid Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Protein Metabolic Process Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Misfolded Protein Granulocyte Differentiation Regulation Of Protein Metabolic Process Regulation Of Inclusion Body Assembly Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Protein Refolding Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Metaphase Plate Congression Protein Localization To Chromosome
Tagcloud ?		chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	11p15 15q21 18p11 1p34 2p 3p12 6p21 6q13 c2orf3 dcdc2 disabled dyx2 dyx3 dyx4 dyx5 dyx6 dyx7 dyx8 dyx9 ekn1 kiaa0319 mrpl19 neurobiologic q12 q16 rd robo1 xq27
Tagcloud (Difference) ?		chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	11p15 15q21 18p11 1p34 2p 3p12 6p21 6q13 c2orf3 dcdc2 disabled dyx2 dyx3 dyx4 dyx5 dyx6 dyx7 dyx8 dyx9 ekn1 kiaa0319 mrpl19 neurobiologic q12 q16 rd robo1 xq27
Tagcloud (Intersection) ?