HSF4 and NUDT21

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		HSF4	NUDT21
Gene Name		heat shock transcription factor 4	nudix (nucleoside diphosphate linked moiety X)-type motif 21
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Centrosome MRNA Cleavage Factor Complex Paraspeckles
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Phosphatase Binding Sequence-specific DNA Binding	RNA Binding MRNA Binding Protein Binding Hydrolase Activity AU-rich Element Binding Protein Homodimerization Activity Histone Deacetylase Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Histone H3-K9 Demethylation Camera-type Eye Development Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Development Protein Homotrimerization	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Processing RNA Splicing Gene Expression MRNA 3'-end Processing Protein Tetramerization
Pathways			mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CDK2AP2 DUSP26 MAPK1 MAPK14 MAPK3 MAPK8 NUDT21 SLC27A5 SMARCA4 ZBED8	51 interactors: A2M ATXN1 CARM1 CLP1 CPSF6 CPSF7 CTNND2 DBN1 DNMT3L DYNC1I1 EED EEF1G EXOSC6 F13A1 FBN3 FLAD1 FUNDC2 GOLGA2 HSF4 IKZF1 ITCH JMJD1C KIAA1377 KIFAP3 MASP1 MYL6 NEDD4 NGEF NIF3L1 POLR2C PSMF1 PTN PYCR1 RBM48 RCC1 RNF19A RPLP1 SEMA5B SF3B1 SHC1 SHFM1 SLC44A1 SNCAIP SNRNP70 SRPK1 TCERG1 TLE1 TRA2A TRIM27 WWOX ZBTB48
Entrez ID		3299	11051
HPRD ID		03896	05400
Ensembl ID		ENSG00000102878	ENSG00000167005
Uniprot IDs		Q9ULV5	O43809
PDB IDs			2CL3 2J8Q 3BAP 3BHO 3MDG 3MDI 3N9U 3P5T 3P6Y 3Q2S 3Q2T
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway MAPK Cascade Regulation Of Golgi Inheritance Neurotrophin Signaling Pathway Regulation Of Innate Immune Response Caveolin-mediated Endocytosis Signal Transduction By Phosphorylation Response To Lipopolysaccharide Regulation Of Golgi Organization Response To Molecule Of Bacterial Origin Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification Regulation Of Early Endosome To Late Endosome Transport Cellular Response To Lipid Peptidyl-serine Phosphorylation Regulation Of Intracellular Transport Immune Response-regulating Signaling Pathway Response To Bacterium Activation Of MAPK Activity Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Factor Platelet Activation Growth Hormone Receptor Signaling Pathway Regulation Of MAPK Cascade Cellular Response To Growth Hormone Stimulus Positive Regulation Of Immune Response	Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Process Cellular Metabolic Process Viral Process Protein K63-linked Ubiquitination RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Polyubiquitination Negative Regulation Of Complement Activation MRNA 3'-end Processing Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Immune System Process Developmental Process RNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Regulation Of Dendrite Development Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression By Genetic Imprinting Blood Coagulation Macromolecule Biosynthetic Process Hemostasis Protein Oligomerization MRNA Polyadenylation Anatomical Structure Development
Tagcloud ?		a3 bf blinding cataract cataracts congenital constantly cryaa cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygc crygd crygs crystallin ftl gja1 gja3 gja8 lim2 maf mip pax6 pitx3 sp2 summarized
Tagcloud (Difference) ?		a3 bf blinding cataract cataracts congenital constantly cryaa cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygc crygd crygs crystallin ftl gja1 gja3 gja8 lim2 maf mip pax6 pitx3 sp2 summarized
Tagcloud (Intersection) ?