HSF1 and PTGES3

Number of citations of the paper that reports this interaction (PMID 9222609)
41

Data Source:
BioGRID (pull down, pull down)

		HSF1	PTGES3
Gene Name		heat shock transcription factor 1	prostaglandin E synthase 3 (cytosolic)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein Complex Pronucleus	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Telomerase Activity Protein Binding Prostaglandin-E Synthase Activity Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Placenta Development Transcription, DNA-templated Protein Phosphorylation Defense Response Female Meiotic Division Spermatogenesis Negative Regulation Of Cell Proliferation Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Heat Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Process Involved In Female Pregnancy Regulation Of Spindle Checkpoint Regulation Of Cellular Response To Heat	Telomere Maintenance Prostaglandin Biosynthetic Process RNA-dependent DNA Replication Signal Transduction Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Cellular Response To Heat Small Molecule Metabolic Process Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat
Pathways		HSF1 activation HSF1-dependent transactivation Attenuation phase Cellular response to heat stress Regulation of HSF1-mediated heat shock response	Arachidonic acid metabolism HSF1 activation HSF1-dependent transactivation Metabolism of lipids and lipoproteins Attenuation phase Cellular response to heat stress Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		47 interactors: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSPA1A HSPA8 MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 PLK1 PPID PRKDC PTGES3 RALBP1 REPS1 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP UBE2I XRCC5 XRCC6 YWHAE	25 interactors: AHR AIP ARNT CASP3 CASP7 CAV3 CD2AP COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSPA1A NR3C1 NR3C2 STIP1 SURF1 TERT THRA
Entrez ID		3297	10728
HPRD ID		00778	06138
Ensembl ID		ENSG00000185122	ENSG00000110958
Uniprot IDs		Q00613	Q15185
PDB IDs		2LDU	1EJF 1LG0
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Heat Cellular Response To Heat Cellular Response To Stress Positive Regulation Of Metabolic Process Response To Heat Viral Process Response To Temperature Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Gene Expression Positive Regulation Of Gene Expression Peptidyl-amino Acid Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Chaperone-mediated Protein Folding Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Negative Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Gene Expression Innate Immune Response Cellular Protein Modification Process Regulation Of Cellular Process Peptidyl-serine Phosphorylation Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process	Regulation Of Cellular Response To Heat Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Heat Regulation Of Apoptotic Process Regulation Of Cell Proliferation Protein Refolding Response To Temperature Stimulus Regulation Of Cellular Component Organization Regulation Of Cell Death Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Response To Heat Regulation Of Nitric-oxide Synthase Activity Response To Unfolded Protein Hormone-mediated Signaling Pathway Regulation Of Protein Complex Assembly Transcription From RNA Polymerase II Promoter Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Metabolic Process Regulation Of Immune System Process Signal Transduction Regulation Of Signal Transduction Cellular Response To Organic Cyclic Compound Negative Regulation Of Inclusion Body Assembly Response To Stress Gene Expression Cellular Response To Organic Substance Positive Regulation Of Myeloid Cell Differentiation Regulation Of Oxidoreductase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C DNA-templated Transcription, Initiation Response To Abiotic Stimulus Positive Regulation Of Microtubule Polymerization Signaling Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Communication Organelle Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Inclusion Body Assembly Positive Regulation Of Protein Metabolic Process Protein Folding Nucleobase-containing Compound Metabolic Process
Tagcloud ?		atg cloned codon composed consensus contiguous derivatives dnaj element ends extension footprinting gaan heat homologue hse hses hsp40 intron minimal mobility motifs primer race sequences shock supershift transcripts upstream	12q13 15q25 15q26 3p22 50k beadchip centric cornell customized decile ecg heritability humancvd illumina lvh lyon nmb prognostically qrs rs2290893 rs2292462 rs4966014 rs6797133 scn5a sokolow sum trait typed voltage
Tagcloud (Difference) ?		atg cloned codon composed consensus contiguous derivatives dnaj element ends extension footprinting gaan heat homologue hse hses hsp40 intron minimal mobility motifs primer race sequences shock supershift transcripts upstream	12q13 15q25 15q26 3p22 50k beadchip centric cornell customized decile ecg heritability humancvd illumina lvh lyon nmb prognostically qrs rs2290893 rs2292462 rs4966014 rs6797133 scn5a sokolow sum trait typed voltage
Tagcloud (Intersection) ?