PTGES3 and ARNT

Number of citations of the paper that reports this interaction (PMID 11879970)
10

Data Source:
HPRD (in vitro, in vivo)

		PTGES3	ARNT
Gene Name		prostaglandin E synthase 3 (cytosolic)	aryl hydrocarbon receptor nuclear translocator
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Telomerase Activity Protein Binding Prostaglandin-E Synthase Activity Unfolded Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Aryl Hydrocarbon Receptor Activity Protein Binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding Enhancer Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Telomere Maintenance Prostaglandin Biosynthetic Process RNA-dependent DNA Replication Signal Transduction Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Cellular Response To Heat Small Molecule Metabolic Process Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Transcription, DNA-templated Positive Regulation Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation MRNA Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways		Arachidonic acid metabolism HSF1 activation HSF1-dependent transactivation Metabolism of lipids and lipoproteins Attenuation phase Cellular response to heat stress Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Regulation of gene expression by Hypoxia-inducible Factor
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419) Platelet counts ( 22139419)	Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552) Urate levels ( 23263486)
Protein-Protein Interactions		25 interactors: AHR AIP ARNT CASP3 CASP7 CAV3 CD2AP COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSPA1A NR3C1 NR3C2 STIP1 SURF1 TERT THRA	37 interactors: ADH5 AHR AHRR AIP ARNT2 BRCA1 CSNK2A1 DIABLO EP300 EPAS1 ESR1 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HIF1A IRAK4 LSM8 MTA3 NCOA1 NCOA2 NCOA7 NCOR2 NPAS4 PML PTGES3 SENP6 SIM1 SIM2 SMAD9 SP1 SRC STRBP TNFAIP1 TRIP11 UBE2I
Entrez ID		10728	405
HPRD ID		06138	00524
Ensembl ID		ENSG00000110958	ENSG00000143437
Uniprot IDs		Q15185	A8K6P0 B0AZM1 F8WAP6 P27540
PDB IDs		1EJF 1LG0	1D7G 1X0O 2A24 2ARN 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Heat Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Heat Regulation Of Apoptotic Process Regulation Of Cell Proliferation Protein Refolding Response To Temperature Stimulus Regulation Of Cellular Component Organization Regulation Of Cell Death Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Response To Heat Regulation Of Nitric-oxide Synthase Activity Response To Unfolded Protein Hormone-mediated Signaling Pathway Regulation Of Protein Complex Assembly Transcription From RNA Polymerase II Promoter Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Metabolic Process Regulation Of Immune System Process Signal Transduction Regulation Of Signal Transduction Cellular Response To Organic Cyclic Compound Negative Regulation Of Inclusion Body Assembly Response To Stress Gene Expression Cellular Response To Organic Substance Positive Regulation Of Myeloid Cell Differentiation Regulation Of Oxidoreductase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C DNA-templated Transcription, Initiation Response To Abiotic Stimulus Positive Regulation Of Microtubule Polymerization Signaling Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Communication Organelle Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Inclusion Body Assembly Positive Regulation Of Protein Metabolic Process Protein Folding Nucleobase-containing Compound Metabolic Process	Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Rhythmic Process Signal Transduction Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Tube Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Developmental Process Involved In Reproduction Signaling Intracellular Receptor Signaling Pathway Embryonic Placenta Development Cell Communication Reproductive Structure Development Response To Stimulus Negative Regulation Of Biosynthetic Process Reproductive System Development Regulation Of Cellular Process Embryo Development Organ Development Single Organism Reproductive Process Multicellular Organismal Development
Tagcloud ?		12q13 15q25 15q26 3p22 50k beadchip centric cornell customized decile ecg heritability humancvd illumina lvh lyon nmb prognostically qrs rs2290893 rs2292462 rs4966014 rs6797133 scn5a sokolow sum trait typed voltage	belong bhlh cobalt confers dimerizes frame helix heterodimer heterodimeric heterologous hif1alpha hif2alpha hif3alpha hifs hrd1 hre hypoxia identity pas prototype reading recognizes resultant shares superfamily tacgtg tension thymus transfections
Tagcloud (Difference) ?		12q13 15q25 15q26 3p22 50k beadchip centric cornell customized decile ecg heritability humancvd illumina lvh lyon nmb prognostically qrs rs2290893 rs2292462 rs4966014 rs6797133 scn5a sokolow sum trait typed voltage	belong bhlh cobalt confers dimerizes frame helix heterodimer heterodimeric heterologous hif1alpha hif2alpha hif3alpha hifs hrd1 hre hypoxia identity pas prototype reading recognizes resultant shares superfamily tacgtg tension thymus transfections
Tagcloud (Intersection) ?