HES1 and TLE2

Number of citations of the paper that reports this interaction (PMID 9874198)
26

Data Source:
BioGRID (pull down, two hybrid)

		HES1	TLE2
Gene Name		hes family bHLH transcription factor 1	transducin-like enhancer of split 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Extracellular Space Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Chaperone Binding N-box Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Ventricular Septum Development Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway STAT Protein Import Into Nucleus Nervous System Development Positive Regulation Of Cell Proliferation Cell Migration Telencephalon Development Midbrain-hindbrain Boundary Morphogenesis Oculomotor Nerve Development Trochlear Nerve Development Hindbrain Morphogenesis Forebrain Radial Glial Cell Differentiation Adenohypophysis Development Lung Development Positive Regulation Of BMP Signaling Pathway Midbrain Development Endocrine Pancreas Development Somatic Stem Cell Maintenance Ascending Aorta Morphogenesis Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Auditory Receptor Cell Fate Determination Positive Regulation Of DNA Binding Regulation Of Fat Cell Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mitotic Cell Cycle, Embryonic Lateral Inhibition Positive Regulation Of JAK-STAT Cascade Cell Maturation Thymus Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Artery Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Ureteric Bud Morphogenesis Labyrinthine Layer Blood Vessel Development Common Bile Duct Development Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Pharyngeal Arch Artery Morphogenesis Glomerulus Vasculature Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Interstitial Fibroblast Development Metanephric Nephron Tubule Morphogenesis Cochlea Development Vascular Smooth Muscle Cell Development Neuronal Stem Cell Maintenance Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation	Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Regulation of beta-cell development Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer truncations of AMER1 destabilize the destruction complex FBXW7 Mutants and NOTCH1 in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes NOTCH1 Intracellular Domain Regulates Transcription deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: APCS APH1A ASGR2 CSNK1E FANCA FANCE FANCF FANCG FANCL FHL1 FOXG1 GAPDH HDAC6 HES6 HEY2 HMGB1 HMGCL ID1 ID2 ID3 ID4 JAK2 LTBR NR4A1 NUDT3 PRKCA PTK2 SIRT1 STAT3 TLE1 TLE2 UBQLN1 YWHAB	16 interactors: BARHL1 EMX2 FOXA3 H3F3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		3280	7089
HPRD ID		00770	03025
Ensembl ID		ENSG00000114315	ENSG00000065717
Uniprot IDs		Q14469	B4DE62 K7EMK7 Q04725
PDB IDs
Enriched GO Terms of Interacting Partners?		System Development Organ Development Multicellular Organismal Development Response To Stress Anatomical Structure Development Regulation Of Cell Death Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Response To Stimulus Rhythmic Process Cellular Metabolic Process Cellular Response To Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Differentiation Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Nitrogen Compound Metabolic Process Circadian Rhythm Regulation Of DNA Binding Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Response To Stress Negative Regulation Of Cell Differentiation Apoptotic Process Negative Regulation Of DNA Binding Regulation Of Cell Differentiation Programmed Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Regulation Of Osteoblast Differentiation Positive Regulation Of Apoptotic Process DNA Repair Response To Growth Factor Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Negative Regulation Of Cell Death	Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Binding Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process System Development Organ Morphogenesis Developmental Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development RNA Biosynthetic Process Anterior/posterior Pattern Specification Cell Migration Regulation Of Binding Positive Regulation Of Transcription, DNA-templated Cell Motility Mesenchymal Cell Development Cell Differentiation Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Gene Expression Central Nervous System Development Odontogenesis Mesenchymal Cell Differentiation Face Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of BMP Signaling Pathway Nucleobase-containing Compound Metabolic Process Activation Of Meiosis Generation Of Neurons Head Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
Tagcloud ?		alterations anatomic astrocytoma astrocytomas biology braf grade hey1 hey2 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable
Tagcloud (Difference) ?		alterations anatomic astrocytoma astrocytomas biology braf grade hey1 hey2 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable
Tagcloud (Intersection) ?