HES1 and FANCF

Number of citations of the paper that reports this interaction (PMID 18550849)
16

Data Source:
HPRD (in vivo, two hybrid)

		HES1	FANCF
Gene Name		hes family bHLH transcription factor 1	Fanconi anemia, complementation group F
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleoplasm Fanconi Anaemia Nuclear Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Chaperone Binding N-box Binding	Molecular_function Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Ventricular Septum Development Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway STAT Protein Import Into Nucleus Nervous System Development Positive Regulation Of Cell Proliferation Cell Migration Telencephalon Development Midbrain-hindbrain Boundary Morphogenesis Oculomotor Nerve Development Trochlear Nerve Development Hindbrain Morphogenesis Forebrain Radial Glial Cell Differentiation Adenohypophysis Development Lung Development Positive Regulation Of BMP Signaling Pathway Midbrain Development Endocrine Pancreas Development Somatic Stem Cell Maintenance Ascending Aorta Morphogenesis Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Auditory Receptor Cell Fate Determination Positive Regulation Of DNA Binding Regulation Of Fat Cell Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mitotic Cell Cycle, Embryonic Lateral Inhibition Positive Regulation Of JAK-STAT Cascade Cell Maturation Thymus Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Artery Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Ureteric Bud Morphogenesis Labyrinthine Layer Blood Vessel Development Common Bile Duct Development Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Pharyngeal Arch Artery Morphogenesis Glomerulus Vasculature Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Interstitial Fibroblast Development Metanephric Nephron Tubule Morphogenesis Cochlea Development Vascular Smooth Muscle Cell Development Neuronal Stem Cell Maintenance Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation	Ovarian Follicle Development DNA Repair Spermatogenesis Biological_process Protein Ubiquitination
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Regulation of beta-cell development Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Fanconi Anemia pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: APCS APH1A ASGR2 CSNK1E FANCA FANCE FANCF FANCG FANCL FHL1 FOXG1 GAPDH HDAC6 HES6 HEY2 HMGB1 HMGCL ID1 ID2 ID3 ID4 JAK2 LTBR NR4A1 NUDT3 PRKCA PTK2 SIRT1 STAT3 TLE1 TLE2 UBQLN1 YWHAB	7 interactors: FANCA FANCC FANCE FANCG HES1 MARK3 OLFM2
Entrez ID		3280	2188
HPRD ID		00770	04589
Ensembl ID		ENSG00000114315	ENSG00000183161
Uniprot IDs		Q14469	A3KME0 Q9NPI8
PDB IDs			2IQC
Enriched GO Terms of Interacting Partners?		System Development Organ Development Multicellular Organismal Development Response To Stress Anatomical Structure Development Regulation Of Cell Death Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Response To Stimulus Rhythmic Process Cellular Metabolic Process Cellular Response To Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Differentiation Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Nitrogen Compound Metabolic Process Circadian Rhythm Regulation Of DNA Binding Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Response To Stress Negative Regulation Of Cell Differentiation Apoptotic Process Negative Regulation Of DNA Binding Regulation Of Cell Differentiation Programmed Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Regulation Of Osteoblast Differentiation Positive Regulation Of Apoptotic Process DNA Repair Response To Growth Factor Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Negative Regulation Of Cell Death	DNA Repair Developmental Process Involved In Reproduction Cellular Response To DNA Damage Stimulus DNA Metabolic Process Single Organism Reproductive Process Reproductive Process Reproductive Structure Development Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Reproductive System Development Female Gonad Development Development Of Primary Female Sexual Characteristics Cellular Response To Stress Negative Regulation Of Forebrain Neuron Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Inhibition Of Neuroepithelial Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Auditory Receptor Cell Fate Determination Trochlear Nerve Development Ascending Aorta Morphogenesis Positive Regulation Of Mitotic Cell Cycle, Embryonic Oculomotor Nerve Development Regulation Of Pro-B Cell Differentiation Regulation Of Auditory Receptor Cell Differentiation STAT Protein Import Into Nucleus Gonad Development Regulation Of Forebrain Neuron Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Timing Of Neuron Differentiation Forebrain Radial Glial Cell Differentiation Comma-shaped Body Morphogenesis Development Of Primary Sexual Characteristics Common Bile Duct Development Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis Renal Interstitial Fibroblast Development Germ Cell Development S-shaped Body Morphogenesis Protein Complex Assembly Reproduction Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Neuron Fate Determination Auditory Receptor Cell Fate Commitment Negative Regulation Of Epidermal Cell Differentiation Positive Regulation Of Astrocyte Differentiation Radial Glial Cell Differentiation
Tagcloud ?		alterations anatomic astrocytoma astrocytomas biology braf grade hey1 hey2 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable	bloom brca1 centrosome circumference connected coregulated coregulation divergent e2f e2f3 exploiting fanca fanconi fluctuations govern id jointly mesh microcephaly networks predisposition rb1 retinoblastoma silico subcellular subnetwork upregulation vital
Tagcloud (Difference) ?		alterations anatomic astrocytoma astrocytomas biology braf grade hey1 hey2 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable	bloom brca1 centrosome circumference connected coregulated coregulation divergent e2f e2f3 exploiting fanca fanconi fluctuations govern id jointly mesh microcephaly networks predisposition rb1 retinoblastoma silico subcellular subnetwork upregulation vital
Tagcloud (Intersection) ?