HRG and THBS1

Number of citations of the paper that reports this interaction (PMID 6438154)
30

Data Source:
HPRD (in vivo)

		HRG	THBS1
Gene Name		histidine-rich glycoprotein	thrombospondin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Platelet Alpha Granule Lumen Endolysosome Phagolysosome Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Cell Surface Sarcoplasmic Reticulum Secretory Granule Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding Immunoglobulin Binding Heme Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding	Phosphatidylserine Binding Glycoprotein Binding Fibronectin Binding Integrin Binding Calcium Ion Binding Protein Binding Heparin Binding Fibroblast Growth Factor Binding Low-density Lipoprotein Particle Binding Identical Protein Binding Laminin Binding Proteoglycan Binding Transforming Growth Factor Beta Binding Fibrinogen Binding Collagen V Binding
	Biological Process	Angiogenesis Platelet Degranulation Positive Regulation Of Immune Response To Tumor Cell Chemotaxis Negative Regulation Of Cell Adhesion Blood Coagulation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Platelet Activation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endopeptidase Activity Response To Organic Cyclic Compound Negative Regulation Of Angiogenesis Platelet Activation Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Fibrinolysis Positive Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Fungus Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Fibrinolysis Heme Export Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Endothelial Cell Chemotaxis	Activation Of MAPK Activity Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Chronic Inflammatory Response Platelet Degranulation Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Outflow Tract Morphogenesis Endocardial Cushion Development Growth Plate Cartilage Development Protein O-linked Glycosylation Immune Response Response To Unfolded Protein Cell Cycle Arrest Cell Adhesion Blood Coagulation Response To Mechanical Stimulus Response To Glucose Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Peptide Cross-linking Platelet Activation Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of CGMP Metabolic Process Response To Magnesium Ion Response To Progesterone Negative Regulation Of Interleukin-12 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Response To Testosterone Cellular Response To Heat Response To Endoplasmic Reticulum Stress Protein O-linked Fucosylation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Response To Drug Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Engulfment Of Apoptotic Cell Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translation Positive Regulation Of Angiogenesis Behavioral Response To Pain Positive Regulation Of Chemotaxis Response To Calcium Ion Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Fibrinolysis Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation	Signaling by PDGF Post-translational protein modification Non-integrin membrane-ECM interactions Platelet degranulation O-glycosylation of TSR domain-containing proteins O-linked glycosylation Syndecan interactions Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 20303064)
Protein-Protein Interactions		13 interactors: C1QA C1QB CHRD FCGR1A FGA FN1 PLG PLSCR1 RABAC1 RCHY1 SPRY1 THBS1 TNFRSF1A	39 interactors: CALCR CALR CD36 CD47 CFH COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL7A1 CORO1A CTSG DCN DHFR ELANE F2 FGA FGF2 FN1 HRG IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 PDGFB PLG SCARB2 SPARC TFPI TGFB1 TNFAIP6 TNFRSF11B
Entrez ID		3273	7057
HPRD ID		00812	01765
Ensembl ID		ENSG00000113905
Uniprot IDs		P04196	P07996
PDB IDs			1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B
Enriched GO Terms of Interacting Partners?		Platelet Activation Platelet Degranulation Defense Response Response To Wounding Blood Coagulation Hemostasis Immune System Process Response To Stress Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Blood Coagulation Exocytosis Phagocytosis, Engulfment Regulation Of Fibrinolysis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Wound Healing Membrane Invagination Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Immune System Process Response To Stimulus Protein Activation Cascade Secretion By Cell Regulation Of Cell-substrate Adhesion Positive Regulation Of Blood Coagulation Regulation Of Endothelial Cell Apoptotic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Acute-phase Response Positive Regulation Of Coagulation Regulation Of Cell Adhesion Secretion Positive Regulation Of Immune Response Peptide Cross-linking Immune Response Positive Regulation Of Wound Healing Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Immune System Process Response To Cytokine Negative Regulation Of Cell-substrate Adhesion Developmental Growth Regulation Of Protein Metabolic Process Negative Regulation Of Blood Coagulation Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Coagulation Vesicle-mediated Transport Negative Regulation Of Wound Healing Innate Immune Response	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Wound Healing Platelet Activation Response To Wounding Platelet Degranulation Blood Coagulation Hemostasis Vesicle-mediated Transport Collagen Catabolic Process Regulation Of Locomotion Response To External Stimulus Collagen Metabolic Process Regulation Of Body Fluid Levels Cardiovascular System Development Regulation Of Cell Migration Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Regulation Of Cell Motility Blood Vessel Development Vasculature Development Response To Stimulus Regulation Of Cellular Component Movement Tissue Development Response To Stress Leukocyte Migration Response To Organic Substance Movement Of Cell Or Subcellular Component Negative Regulation Of Wound Healing Endocytosis Cell Migration Regulation Of Wound Healing Cell Activation Blood Vessel Morphogenesis Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Anatomical Structure Morphogenesis Exocytosis Positive Regulation Of Cellular Component Movement Immune System Process Positive Regulation Of Locomotion Regulation Of Blood Coagulation Multicellular Organismal Development Negative Regulation Of Blood Coagulation Anatomical Structure Development Negative Regulation Of Coagulation System Development
Tagcloud ?		absorbed attack c5b c9 complement connected determinant erythrocytes guinea histidine lysis m1 m57 mga name overlapping possesses pyogenes regulon sensitized sepharose serotype serotypes sheep sic streptococcal streptococcus translates virulence	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs2
Tagcloud (Difference) ?		absorbed attack c5b c9 complement connected determinant erythrocytes guinea histidine lysis m1 m57 mga name overlapping possesses pyogenes regulon sensitized sepharose serotype serotypes sheep sic streptococcal streptococcus translates virulence	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs2
Tagcloud (Intersection) ?