THBS1 and CD36

Number of citations of the paper that reports this interaction (PMID 10487979)
31

Data Source:
HPRD (in vivo)

		THBS1	CD36
Gene Name		thrombospondin 1	CD36 molecule (thrombospondin receptor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Cell Surface Sarcoplasmic Reticulum Secretory Granule Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Membrane Raft Phagocytic Vesicle
	Molecular Function	Phosphatidylserine Binding Glycoprotein Binding Fibronectin Binding Integrin Binding Calcium Ion Binding Protein Binding Heparin Binding Fibroblast Growth Factor Binding Low-density Lipoprotein Particle Binding Identical Protein Binding Laminin Binding Proteoglycan Binding Transforming Growth Factor Beta Binding Fibrinogen Binding Collagen V Binding	Low-density Lipoprotein Receptor Activity High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Transforming Growth Factor Beta Binding Thrombospondin Receptor Activity Lipoteichoic Acid Receptor Activity Lipoprotein Particle Binding
	Biological Process	Activation Of MAPK Activity Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Chronic Inflammatory Response Platelet Degranulation Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Outflow Tract Morphogenesis Endocardial Cushion Development Growth Plate Cartilage Development Protein O-linked Glycosylation Immune Response Response To Unfolded Protein Cell Cycle Arrest Cell Adhesion Blood Coagulation Response To Mechanical Stimulus Response To Glucose Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Peptide Cross-linking Platelet Activation Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of CGMP Metabolic Process Response To Magnesium Ion Response To Progesterone Negative Regulation Of Interleukin-12 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Response To Testosterone Cellular Response To Heat Response To Endoplasmic Reticulum Stress Protein O-linked Fucosylation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Response To Drug Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Engulfment Of Apoptotic Cell Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translation Positive Regulation Of Angiogenesis Behavioral Response To Pain Positive Regulation Of Chemotaxis Response To Calcium Ion Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Fibrinolysis Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell-matrix Adhesion Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Platelet Degranulation MyD88-dependent Toll-like Receptor Signaling Pathway Lipid Metabolic Process Receptor-mediated Endocytosis Phagocytosis, Recognition Cell Adhesion Cell Surface Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction Blood Coagulation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Plasma Membrane Long-chain Fatty Acid Transport Lipid Storage CGMP-mediated Signaling Platelet Activation Positive Regulation Of Blood Coagulation Cholesterol Transport Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance Response To Stilbenoid Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Lipoprotein Transport Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of MAPK Cascade Negative Regulation Of Growth Of Symbiont In Host Cellular Lipid Metabolic Process Small Molecule Metabolic Process Long-chain Fatty Acid Import Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Cellular Response To Bacterial Lipopeptide Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Hydroperoxide Regulation Of Removal Of Superoxide Radicals Positive Regulation Of Blood Microparticle Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Signaling by PDGF Post-translational protein modification Non-integrin membrane-ECM interactions Platelet degranulation O-glycosylation of TSR domain-containing proteins O-linked glycosylation Syndecan interactions Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	PPARA activates gene expression Metabolism of lipids and lipoproteins Platelet degranulation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Response to elevated platelet cytosolic Ca2+ Transcriptional regulation of white adipocyte differentiation MyD88:Mal cascade initiated on plasma membrane Class I MHC mediated antigen processing & presentation Innate Immune System Fatty acid, triacylglycerol, and ketone body metabolism Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Platelet activation, signaling and aggregation Scavenging by Class B Receptors Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS			HDL cholesterol ( 23726366) Left ventricular mass ( 19454037) Mean platelet volume ( 22423221) Response to fenofibrate ( 22890011)
Protein-Protein Interactions		39 interactors: CALCR CALR CD36 CD47 CFH COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL7A1 CORO1A CTSG DCN DHFR ELANE F2 FGA FGF2 FN1 HRG IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 PDGFB PLG SCARB2 SPARC TFPI TGFB1 TNFAIP6 TNFRSF11B	18 interactors: APP CD9 CHRD COL1A1 COL1A2 FYN HSD11B1 ITGA2B ITGA6 ITGB1 ITGB3 LDLR LYN MATK SRC THBS1 VLDLR YES1
Entrez ID		7057	948
HPRD ID		01765	01430
Ensembl ID			ENSG00000135218
Uniprot IDs		P07996	A4D1B1 P16671
PDB IDs		1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Wound Healing Platelet Activation Response To Wounding Platelet Degranulation Blood Coagulation Hemostasis Vesicle-mediated Transport Collagen Catabolic Process Regulation Of Locomotion Response To External Stimulus Collagen Metabolic Process Regulation Of Body Fluid Levels Cardiovascular System Development Regulation Of Cell Migration Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Regulation Of Cell Motility Blood Vessel Development Vasculature Development Response To Stimulus Regulation Of Cellular Component Movement Tissue Development Response To Stress Leukocyte Migration Response To Organic Substance Movement Of Cell Or Subcellular Component Negative Regulation Of Wound Healing Endocytosis Cell Migration Regulation Of Wound Healing Cell Activation Blood Vessel Morphogenesis Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Anatomical Structure Morphogenesis Exocytosis Positive Regulation Of Cellular Component Movement Immune System Process Positive Regulation Of Locomotion Regulation Of Blood Coagulation Multicellular Organismal Development Negative Regulation Of Blood Coagulation Anatomical Structure Development Negative Regulation Of Coagulation System Development	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Platelet Activation Response To Wounding Leukocyte Migration Movement Of Cell Or Subcellular Component Locomotion Cell Activation Anatomical Structure Morphogenesis Vesicle-mediated Transport Cell Migration Cell Motility Endocytosis Platelet Degranulation Anatomical Structure Development Peptidyl-tyrosine Autophosphorylation System Development Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Regulation Of Cell Adhesion Developmental Process Response To External Stimulus Multicellular Organismal Development Axonogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Differentiation Positive Regulation Of Cellular Component Movement Response To Stress Immune System Process Axon Development Positive Regulation Of Locomotion Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Regulation Of Cell Motility Neuron Projection Morphogenesis Organ Development Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Integrin-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Abiotic Stimulus Cell Projection Organization
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs2	benzidine bfu cd41 cd71 cfu csf cytokines e2 epo erythroid erythropoiesis erythropoietin events express gata glycophorin gm interestingly late leukemia line lineage pas progenitor reagent stages strictly transforming understand
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs2	benzidine bfu cd41 cd71 cfu csf cytokines e2 epo erythroid erythropoiesis erythropoietin events express gata glycophorin gm interestingly late leukemia line lineage pas progenitor reagent stages strictly transforming understand
Tagcloud (Intersection) ?