HIST1H1A and LIMK2

Number of citations of the paper that reports this interaction (PMID 8537403)
36

Data Source:
BioGRID (enzymatic study)

		HIST1H1A	LIMK2
Gene Name		histone cluster 1, H1a	LIM domain kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nuclear Euchromatin	Nucleus Cytoplasm Cis-Golgi Network
	Molecular Function	Protein Binding Chromatin DNA Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Protein Heterodimerization Activity
	Biological Process	Nucleosome Assembly Spermatogenesis	Protein Phosphorylation Spermatogenesis Phosphorylation
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase	EPHB-mediated forward signaling Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS			Paclitaxel-induced neuropathy ( 23776197) Type 2 diabetes nephropathy ( 21150874)
Protein-Protein Interactions		45 interactors: AEBP2 CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L4 NASP PARP1 PARP3 PELP1 PKN1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 SUZ12 TERF1 TERF2IP TLK1 WHSC1L1	9 interactors: CDC42BPA CFL1 GSN HIPK3 HIST1H1A LIMK1 MBP PARD3 ROCK1
Entrez ID		3024	3985
HPRD ID		00820	03585
Ensembl ID		ENSG00000124610	ENSG00000182541
Uniprot IDs		Q02539	E7EUC1 P53671
PDB IDs			1X6A
Enriched GO Terms of Interacting Partners?		Chromosome Organization Cell Cycle Chromatin Organization Chromatin Modification Regulation Of Cell Cycle Organelle Organization Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Histone Modification Regulation Of Metabolic Process Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Protein Phosphorylation Regulation Of Mitotic Cell Cycle Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Division Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle DNA Metabolic Process Cellular Response To Stress Response To Stress Histone Phosphorylation Regulation Of Catalytic Activity Peptidyl-amino Acid Modification Cellular Metabolic Process Regulation Of Cell Cycle Process Phosphorylation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic	Actin Filament-based Process Regulation Of Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Rho Protein Signal Transduction Apical Constriction Ephrin Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Cell Projection Morphogenesis Cell Part Morphogenesis Neurogenesis Cell Morphogenesis Organelle Organization Regulation Of Cytoskeleton Organization Axonogenesis Cell Projection Organization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Positive Regulation Of Cytoskeleton Organization Nervous System Development Protein Phosphorylation Neuron Projection Morphogenesis Ras Protein Signal Transduction Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Actin-mediated Cell Contraction Generation Of Neurons Neuron Projection Development Cell Migration Epithelial Cell Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of Organelle Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament-based Movement Cell Development Regulation Of Stress Fiber Assembly Response To External Stimulus Regulation Of Actin Filament Depolymerization Phosphorylation Neuron Development Intracellular Signal Transduction Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Axon Guidance Execution Phase Of Apoptosis Positive Regulation Of Organelle Organization
Tagcloud ?			aberrant cdk4 cofilin cyclin d1 death downregulation drp1 dynamic effectors epilepticus fission interacting kip1 mediators necrotic neuronal p27 programmed rescue rho rock se subsequently turn unsuspected upregulated vulnerable
Tagcloud (Difference) ?			aberrant cdk4 cofilin cyclin d1 death downregulation drp1 dynamic effectors epilepticus fission interacting kip1 mediators necrotic neuronal p27 programmed rescue rho rock se subsequently turn unsuspected upregulated vulnerable
Tagcloud (Intersection) ?