FHOD1 and BBS4

Number of citations of the paper that reports this interaction (PMID 18000879)
5

Data Source:
BioGRID (two hybrid)

		FHOD1	BBS4
Gene Name		formin homology 2 domain containing 1	Bardet-Biedl syndrome 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Membrane Bleb	Pericentriolar Material Centrosome Centriole Cytosol Cilium Nonmotile Primary Cilium Motile Cilium Centriolar Satellite BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	RNA Polymerase II Repressing Transcription Factor Binding Microtubule Motor Activity Protein Binding Dynactin Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Stress Fiber Assembly	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Neural Tube Closure Retina Homeostasis Heart Looping Negative Regulation Of Systemic Arterial Blood Pressure Organelle Organization Spermatid Development Visual Perception Sensory Perception Of Smell Metabolic Process Negative Regulation Of Gene Expression Protein Transport Dendrite Development Regulation Of Lipid Metabolic Process Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Regulation Of Cytokinesis Protein Localization To Organelle Microtubule Anchoring At Centrosome Nonmotile Primary Cilium Assembly Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Cilium Assembly Fat Cell Differentiation Photoreceptor Cell Maintenance Positive Regulation Of Cilium Assembly Retinal Rod Cell Development Intracellular Transport Brain Morphogenesis Sensory Processing Centrosome Organization Maintenance Of Protein Location In Nucleus Cilium Morphogenesis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Protein Localization To Centrosome
Pathways			Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ACTA1 ACTG1 APC BBS1 BBS2 BBS4 BBS7 CR2 EXOSC8 GRB2 LNPEP NCOA6 PFN2 PPARG PRKG1 RAC1 RANBP2 RNF5 YWHAZ ZMYND8	14 interactors: ACTB BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 MYOG PAX2 PCM1
Entrez ID		29109	585
HPRD ID		06049	08982
Ensembl ID		ENSG00000135723	ENSG00000140463
Uniprot IDs		Q9Y613	Q96RK4
PDB IDs		3DAD
Enriched GO Terms of Interacting Partners?		Nonmotile Primary Cilium Assembly Cell Projection Organization Retina Homeostasis Cell Projection Morphogenesis Cell Part Morphogenesis Tissue Homeostasis Positive Regulation Of Organelle Organization Cellular Component Assembly Cell Morphogenesis Organelle Organization Multicellular Organismal Homeostasis Organelle Assembly Cytoskeleton Organization Cellular Response To Stimulus Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Protein Polymerization Regulation Of Cell Projection Assembly Photoreceptor Cell Maintenance Cell Differentiation Cell Projection Assembly Fat Cell Differentiation Melanosome Transport Pigment Granule Transport Membrane Organization Establishment Of Melanosome Localization Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Nervous System Development Regulation Of Organelle Organization Melanosome Localization Signal Transduction Cell Development Organ Development Homeostatic Process Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Cilium Assembly Visual Perception Sensory Perception Of Light Stimulus Anatomical Structure Formation Involved In Morphogenesis Cell Activation Signaling Cilium Organization Leptin-mediated Signaling Pathway Cell Communication Cellular Pigmentation Platelet Activation Anatomical Structure Development Blood Coagulation	Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Cell Fate Commitment Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Positive Regulation Of Muscle Atrophy Golgi To Plasma Membrane CFTR Protein Transport Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Negative Regulation Of Cell Differentiation Stem Cell Differentiation Regulation Of Heart Rate Vesicle-mediated Transport Organelle Organization Pronephric Field Specification Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Positive Regulation Of Metanephric DCT Cell Differentiation Regulation Of Metanephros Size S-methylmethionine Cycle S-methylmethionine Metabolic Process Cellular Metabolic Process Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Organelle Localization Cellular Response To Tumor Necrosis Factor Amino-acid Betaine Catabolic Process Regulation Of Homocysteine Metabolic Process Negative Regulation Of Cytolysis Kidney Rudiment Formation Positive Regulation Of Cellular Metabolic Process G2/M Transition Of Mitotic Cell Cycle Paramesonephric Duct Development Vestibulocochlear Nerve Formation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Metanephric Nephron Tubule Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Regulation Of Kidney Size Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process
Tagcloud ?		actin adhesions adhesive arrays assembly bilayers clusters coordinated depends find force formin impairs insights integrin integrins matrix maturation pillar polymerization question raises recruited rho sensing spreading steps substrates upstream	129p3 6byj acat1 adip5 adipose adpgk crabp1 csk cyp19a1 depot depots dpp8 fatness gonadal hexa il18 intercross linkage lipc lod lsm16 man2c1 mpi1 neil1 qtl retroperitoneal rs30280752 summed thsd4
Tagcloud (Difference) ?		actin adhesions adhesive arrays assembly bilayers clusters coordinated depends find force formin impairs insights integrin integrins matrix maturation pillar polymerization question raises recruited rho sensing spreading steps substrates upstream	129p3 6byj acat1 adip5 adipose adpgk crabp1 csk cyp19a1 depot depots dpp8 fatness gonadal hexa il18 intercross linkage lipc lod lsm16 man2c1 mpi1 neil1 qtl retroperitoneal rs30280752 summed thsd4
Tagcloud (Intersection) ?