FHOD1 and LNPEP

Number of citations of the paper that reports this interaction (PMID 12677009)
9

Data Source:
HPRD (two hybrid, in vitro)

		FHOD1	LNPEP
Gene Name		formin homology 2 domain containing 1	leucyl/cystinyl aminopeptidase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Membrane Bleb	Extracellular Region Intracellular Lysosomal Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Early Endosome Lumen Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Aminopeptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Stress Fiber Assembly	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Cell-cell Signaling Female Pregnancy Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I SMAD Protein Signal Transduction Membrane Organization
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Translocation of GLUT4 to the plasma membrane Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		20 interactors: ACTA1 ACTG1 APC BBS1 BBS2 BBS4 BBS7 CR2 EXOSC8 GRB2 LNPEP NCOA6 PFN2 PPARG PRKG1 RAC1 RANBP2 RNF5 YWHAZ ZMYND8	8 interactors: FATE1 FHOD1 REL SLC2A4 SMAD9 TCF4 TNKS TNKS2
Entrez ID		29109	4012
HPRD ID		06049	01041
Ensembl ID		ENSG00000135723	ENSG00000113441
Uniprot IDs		Q9Y613	Q9UIQ6
PDB IDs		3DAD
Enriched GO Terms of Interacting Partners?		Nonmotile Primary Cilium Assembly Cell Projection Organization Retina Homeostasis Cell Projection Morphogenesis Cell Part Morphogenesis Tissue Homeostasis Positive Regulation Of Organelle Organization Cellular Component Assembly Cell Morphogenesis Organelle Organization Multicellular Organismal Homeostasis Organelle Assembly Cytoskeleton Organization Cellular Response To Stimulus Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Protein Polymerization Regulation Of Cell Projection Assembly Photoreceptor Cell Maintenance Cell Differentiation Cell Projection Assembly Fat Cell Differentiation Melanosome Transport Pigment Granule Transport Membrane Organization Establishment Of Melanosome Localization Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Nervous System Development Regulation Of Organelle Organization Melanosome Localization Signal Transduction Cell Development Organ Development Homeostatic Process Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Cilium Assembly Visual Perception Sensory Perception Of Light Stimulus Anatomical Structure Formation Involved In Morphogenesis Cell Activation Signaling Cilium Organization Leptin-mediated Signaling Pathway Cell Communication Cellular Pigmentation Platelet Activation Anatomical Structure Development Blood Coagulation	Positive Regulation Of Telomere Maintenance Via Telomerase Protein Auto-ADP-ribosylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Protein ADP-ribosylation Regulation Of Canonical Wnt Signaling Pathway Protein Localization To Chromosome Regulation Of Transcription From RNA Polymerase II Promoter Wnt Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Wnt Signaling Pathway Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Carbohydrate Metabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Amylopectin Biosynthetic Process Protein Localization To Organelle Biosynthetic Process Multicellular Organism Growth Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA Replication Fat Cell Differentiation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Positive Regulation Of DNA Metabolic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Protein Poly-ADP-ribosylation Positive Regulation Of Wnt Signaling Pathway Protein Polyubiquitination Maintenance Of DNA Repeat Elements Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Glucose Homeostasis Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Regulation Of Organelle Organization Embryonic Genitalia Morphogenesis Mullerian Duct Regression Myoblast Fate Commitment
Tagcloud ?		actin adhesions adhesive arrays assembly bilayers clusters coordinated depends find force formin impairs insights integrin integrins matrix maturation pillar polymerization question raises recruited rho sensing spreading steps substrates upstream	aminopeptidase compensated cystinyl disrupts evolutionarily feline footprint genetics hanging heterozygotes inc inked intron juvenile ko leucyl lexicon littermates lix1 mating mendelian muscular neuromuscular neuron recessive rodent rotarod sma transcript
Tagcloud (Difference) ?		actin adhesions adhesive arrays assembly bilayers clusters coordinated depends find force formin impairs insights integrin integrins matrix maturation pillar polymerization question raises recruited rho sensing spreading steps substrates upstream	aminopeptidase compensated cystinyl disrupts evolutionarily feline footprint genetics hanging heterozygotes inc inked intron juvenile ko leucyl lexicon littermates lix1 mating mendelian muscular neuromuscular neuron recessive rodent rotarod sma transcript
Tagcloud (Intersection) ?