NR3C1 and NR3C2

Number of citations of the paper that reports this interaction (PMID 11154266)
16

Data Source:
HPRD (in vivo, in vitro)

		NR3C1	NR3C2
Gene Name		nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	nuclear receptor subfamily 3, group C, member 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Membrane	Nucleoplasm Endoplasmic Reticulum Membrane Receptor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Glucocorticoid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Glucocorticoid-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Protein Dimerization Activity Steroid Hormone Binding	Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Gluconeogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Glucocorticoid Metabolic Process Gene Expression Chromatin Modification Adrenal Gland Development Regulation Of Glucocorticoid Biosynthetic Process Maternal Behavior Glucocorticoid Receptor Signaling Pathway Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Duct Morphogenesis Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Glucocorticoid Mediated Signaling Pathway	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Gene Expression Steroid Hormone Mediated Signaling Pathway
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs		Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol Beclometasone dipropionate Betamethasone Desoximetasone Fluticasone Propionate Fluocinolone Acetonide Halobetasol Propionate Triamcinolone Prednisone Flumethasone Pivalate Fludrocortisone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol Rimexolone Methylprednisolone Clobetasol Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Ciclesonide Hexane-1,6-Diol Difluprednate Fluticasone furoate	Nimodipine Progesterone Spironolactone Fluticasone Propionate Fludrocortisone Eplerenone Felodipine Desoxycorticosterone Pivalate Drospirenone Aldosterone (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE
Diseases
GWAS			Biochemical measures ( 19260141) Corneal structure ( 23291589) Subcutaneous adipose tissue ( 22589738) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		135 interactors: ADA AR ARPC5 BAG1 CALM1 CALR CEBPA CEBPB CENPB CHD9 COPS6 CREB1 CREBBP DAP3 DAXX DCAF6 DDX54 ECD ETS1 ETS2 FKBP4 FTH1 FYN GNB1 GNB2 GNB2L1 GRIP1 HDAC6 HMGB1 HMGB2 HMOX2 HNRNPA1 HNRNPU HSP90AA1 HSPA1A HSPD1 IDE IFNGR2 JUN KAT5 KDM5A KPNA2 LCK LRIF1 MAFF MAPK1 MAPK15 MAPK8 MDM2 MED1 MED14 MED25 MSX2 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NR0B1 NR1H3 NR2E3 NR2F2 NR2F6 NR3C2 NR4A1 NRIP1 ONECUT1 OSGEP PBX1 PELP1 PIAS2 PML POLR1D POU1F1 POU2F1 POU2F2 PPARGC1A PRKACA PRKDC PRPF6 PSMC3IP PTGES3 PTMS RAD54L2 RAD9A RAF1 RAN RARA RBM14 RELA RNF14 RXRB SFN SLC25A4 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCD1 SMARCE1 SRA1 SRC STAT3 STAT5A STAT5B SUMO1 SUMO4 SVIL SYT1 TADA2A TBP TDG TGFB1I1 TMF1 TP53 TRIM24 TRIM28 TSG101 TXN UBB UBE2I UBE2L3 YWHAH ZBTB16 ZBTB20 ZBTB3 ZBTB9 ZNF496	19 interactors: ACSL1 ACTA1 ACTG1 AR EIF3I FKBP4 HSP90AA1 HSPA4 NR3C1 PIAS1 PIAS3 PROX1 PTGES3 RABAC1 RXRA SRC SUMO1 TRIM24 UBE2I
Entrez ID		2908	4306
HPRD ID		00679	02991
Ensembl ID		ENSG00000113580	ENSG00000151623
Uniprot IDs		B7Z7I2 E5KQF5 E5KQF6 F1D8N4 P04150	B0ZBF6 P08235
PDB IDs		1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4HN5 4HN6	1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Cellular Metabolic Process Cellular Response To Hormone Stimulus Biosynthetic Process Regulation Of Cellular Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Androgen Receptor Signaling Pathway Response To Steroid Hormone Response To Organic Cyclic Compound Transcription Initiation From RNA Polymerase II Promoter Response To Lipid DNA-templated Transcription, Initiation Cell Differentiation	Intracellular Steroid Hormone Receptor Signaling Pathway Protein Sumoylation Intracellular Receptor Signaling Pathway Cellular Component Assembly Response To Organic Substance Cellular Response To Steroid Hormone Stimulus Response To Hormone Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Steroid Hormone Gland Development Actomyosin Structure Organization Regulation Of Cellular Response To Heat Response To Lipid Response To Organic Cyclic Compound Androgen Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Hormone-mediated Signaling Pathway Response To Stimulus Cellular Response To Hormone Stimulus Protein Import Into Mitochondrial Outer Membrane Cellular Macromolecular Complex Assembly Skeletal Muscle Thin Filament Assembly Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Skeletal Myofibril Assembly Negative Regulation Of RNA Biosynthetic Process Cellular Response To Lipid Cellular Response To Heat Positive Regulation Of Protein Metabolic Process Prostate Gland Development Striated Muscle Cell Differentiation Myofibril Assembly Organelle Organization Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Peptidyl-lysine Modification Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Sumoylation Chaperone-mediated Protein Complex Assembly Peptidyl-amino Acid Modification Steroid Hormone Mediated Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation
Tagcloud ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	11beta 11betahsd1 a3669g abcb1 adjustments bcl1 cassette cognitive cs cushing educational gc glucocorticoid hydroxysteroid i180v impairments interquartile mineralocorticoid neuropsychological nr3c1 participated polymorphisms prereceptor reading remission rs1045642 rs11119328 speed working
Tagcloud (Difference) ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	11beta 11betahsd1 a3669g abcb1 adjustments bcl1 cassette cognitive cs cushing educational gc hydroxysteroid i180v impairments interquartile mineralocorticoid neuropsychological participated polymorphisms prereceptor reading remission rs1045642 rs11119328 speed working
Tagcloud (Intersection) ?		glucocorticoid nr3c1