NR3C1 and NCOA6

Number of citations of the paper that reports this interaction (PMID 10866662)
36

Data Source:
HPRD (two hybrid)

		NR3C1	NCOA6
Gene Name		nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	nuclear receptor coactivator 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Membrane	Nucleus Nucleoplasm Transcription Factor Complex Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Glucocorticoid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Glucocorticoid-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Protein Dimerization Activity Steroid Hormone Binding	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Regulation Of Gluconeogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Glucocorticoid Metabolic Process Gene Expression Chromatin Modification Adrenal Gland Development Regulation Of Glucocorticoid Biosynthetic Process Maternal Behavior Glucocorticoid Receptor Signaling Pathway Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Duct Morphogenesis Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Glucocorticoid Mediated Signaling Pathway	DNA Replication DNA Repair DNA Recombination DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Intracellular Estrogen Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Labyrinthine Layer Blood Vessel Development
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs		Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol Beclometasone dipropionate Betamethasone Desoximetasone Fluticasone Propionate Fluocinolone Acetonide Halobetasol Propionate Triamcinolone Prednisone Flumethasone Pivalate Fludrocortisone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol Rimexolone Methylprednisolone Clobetasol Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Ciclesonide Hexane-1,6-Diol Difluprednate Fluticasone furoate
Diseases
GWAS
Protein-Protein Interactions		135 interactors: ADA AR ARPC5 BAG1 CALM1 CALR CEBPA CEBPB CENPB CHD9 COPS6 CREB1 CREBBP DAP3 DAXX DCAF6 DDX54 ECD ETS1 ETS2 FKBP4 FTH1 FYN GNB1 GNB2 GNB2L1 GRIP1 HDAC6 HMGB1 HMGB2 HMOX2 HNRNPA1 HNRNPU HSP90AA1 HSPA1A HSPD1 IDE IFNGR2 JUN KAT5 KDM5A KPNA2 LCK LRIF1 MAFF MAPK1 MAPK15 MAPK8 MDM2 MED1 MED14 MED25 MSX2 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NR0B1 NR1H3 NR2E3 NR2F2 NR2F6 NR3C2 NR4A1 NRIP1 ONECUT1 OSGEP PBX1 PELP1 PIAS2 PML POLR1D POU1F1 POU2F1 POU2F2 PPARGC1A PRKACA PRKDC PRPF6 PSMC3IP PTGES3 PTMS RAD54L2 RAD9A RAF1 RAN RARA RBM14 RELA RNF14 RXRB SFN SLC25A4 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCD1 SMARCE1 SRA1 SRC STAT3 STAT5A STAT5B SUMO1 SUMO4 SVIL SYT1 TADA2A TBP TDG TGFB1I1 TMF1 TP53 TRIM24 TRIM28 TSG101 TXN UBB UBE2I UBE2L3 YWHAH ZBTB16 ZBTB20 ZBTB3 ZBTB9 ZNF496	64 interactors: AR ASCC1 ATF2 BCL3 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 HIST2H3C HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOA1 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335
Entrez ID		2908	23054
HPRD ID		00679	05599
Ensembl ID		ENSG00000113580	ENSG00000198646
Uniprot IDs		B7Z7I2 E5KQF5 E5KQF6 F1D8N4 P04150	F6M2K2 Q14686
PDB IDs		1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4HN5 4HN6
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Cellular Metabolic Process Cellular Response To Hormone Stimulus Biosynthetic Process Regulation Of Cellular Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Androgen Receptor Signaling Pathway Response To Steroid Hormone Response To Organic Cyclic Compound Transcription Initiation From RNA Polymerase II Promoter Response To Lipid DNA-templated Transcription, Initiation Cell Differentiation	Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Steroid Hormone Mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Lipid Response To Hormone Cellular Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular
Tagcloud (Difference) ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular
Tagcloud (Intersection) ?