GCH1 and ATP1B1

Number of citations of the paper that reports this interaction (PMID 16696853)
9

Data Source:
HPRD (two hybrid)

		GCH1	ATP1B1
Gene Name		GTP cyclohydrolase 1	ATPase, Na+/K+ transporting, beta 1 polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein Complex	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Vesicle Sarcolemma Extracellular Vesicular Exosome
	Molecular Function	GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Coenzyme Binding	ATPase Activator Activity Sodium:potassium-exchanging ATPase Activity Protein Binding MHC Class II Protein Complex Binding ATPase Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Metabolic Process Regulation Of Blood Pressure Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Blood Pressure Nitric Oxide Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Protein Heterooligomerization	Response To Hypoxia Cellular Calcium Ion Homeostasis Cellular Sodium Ion Homeostasis Cell Adhesion Blood Coagulation Potassium Ion Import Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Potassium Ion Homeostasis Positive Regulation Of ATPase Activity Ion Transmembrane Transport Sodium Ion Export From Cell Protein Transport Into Plasma Membrane Raft Protein Stabilization Leukocyte Migration Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Protein Localization To Plasma Membrane Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Sodium Ion Export From Cell Positive Regulation Of Calcium:sodium Antiporter Activity Positive Regulation Of Potassium Ion Import
Pathways		Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Ion transport by P-type ATPases Ion channel transport Basigin interactions Cell surface interactions at the vascular wall
Drugs		Guanine
Diseases
GWAS		Obesity-related traits ( 23251661) Rheumatoid arthritis ( 22446963)	QT interval ( 23166209 19305409)
Protein-Protein Interactions		13 interactors: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ	17 interactors: BACE1 BARD1 BRCA1 CRIP2 DDAH2 EGFR EZH2 FXYD1 FXYD7 GCH1 KMT2B LRIF1 NDRG2 PAXIP1 PSME1 TRMT2A USP4
Entrez ID		2643	481
HPRD ID		02573	01663
Ensembl ID		ENSG00000131979	ENSG00000143153
Uniprot IDs		P30793 Q8IZH9	A3KLL5 A6NGH2 P05026
PDB IDs		1FB1
Enriched GO Terms of Interacting Partners?		Intracellular Transport Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Membrane Organization Intracellular Protein Transport Cellular Localization Positive Regulation Of ATPase Activity Regulation Of ATPase Activity Regulated Secretory Pathway Golgi Vesicle Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Negative Regulation Of Fibril Organization Negative Regulation Of GTP Cyclohydrolase I Activity Establishment Of Protein Localization To Plasma Membrane Cell-cell Signaling Protein Stabilization Positive Regulation Of Calcium:sodium Antiporter Activity Endomembrane System Organization Positive Regulation Of Potassium Ion Import Regulation Of Fibril Organization Protein Localization Secretion By Cell Golgi Reassembly Positive Regulation Of Sodium Ion Export From Cell Regulation Of Protein Stability Regulation Of Neurotransmitter Levels Regulation Of Metabolic Process Protein Transport Into Plasma Membrane Raft Clathrin Coat Disassembly Protein Localization To Plasma Membrane Protein Localization To Plasma Membrane Raft Histamine Secretion By Mast Cell Sodium Ion Export From Cell Establishment Of Golgi Localization Secretion Positive Regulation Of Metabolic Process Sodium Ion Export Golgi Inheritance Regulation Of Catalytic Activity Cellular Potassium Ion Homeostasis Vesicle-mediated Transport Histamine Secretion Transport Protein Transport Into Membrane Raft Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Plasma Membrane Organization Embryonic Process Involved In Female Pregnancy	Regulation Of Histone H3-K4 Methylation Regulation Of Histone Methylation Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Negative Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H3-K4 Methylation Histone Lysine Methylation Signal Transduction In Response To DNA Damage Peptidyl-lysine Methylation Nitrogen Compound Metabolic Process Nitric Oxide Biosynthetic Process Regulation Of Protein Metabolic Process Reactive Oxygen Species Metabolic Process Signal Transduction By P53 Class Mediator Positive Regulation Of Histone Acetylation Histone Methylation Regulation Of Histone Modification Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Methylation Nitric Oxide Metabolic Process Positive Regulation Of Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Histone H3-K4 Methylation Protein Methylation Positive Regulation Of Histone Methylation Positive Regulation Of DNA Repair Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Gene Expression, Epigenetic Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Histone Acetylation Negative Regulation Of Cell Death
Tagcloud ?		allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val	activin belongs bip caps elusive folding grp78 homeobox hspa5 hspa5mo knock lhx1 lim malformation morphants morpholino mos multifunctional oligonucleotides participates pax2 pronephric pronephros rescued residing serves specification unfolded xenopus
Tagcloud (Difference) ?		allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val	activin belongs bip caps elusive folding grp78 homeobox hspa5 hspa5mo knock lhx1 lim malformation morphants morpholino mos multifunctional oligonucleotides participates pax2 pronephric pronephros rescued residing serves specification unfolded xenopus
Tagcloud (Intersection) ?