GCH1 and CNRIP1

Number of citations of the paper that reports this interaction (PMID 16696853)
9

Data Source:
BioGRID (two hybrid)

		GCH1	CNRIP1
Gene Name		GTP cyclohydrolase 1	cannabinoid receptor interacting protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein Complex
	Molecular Function	GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Coenzyme Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Metabolic Process Regulation Of Blood Pressure Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Blood Pressure Nitric Oxide Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Protein Heterooligomerization
Pathways		Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Guanine
Diseases
GWAS		Obesity-related traits ( 23251661) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		13 interactors: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ	2 interactors: BRCA1 GCH1
Entrez ID		2643	25927
HPRD ID		02573	12813
Ensembl ID		ENSG00000131979	ENSG00000119865
Uniprot IDs		P30793 Q8IZH9	Q96F85
PDB IDs		1FB1
Enriched GO Terms of Interacting Partners?		Intracellular Transport Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Membrane Organization Intracellular Protein Transport Cellular Localization Positive Regulation Of ATPase Activity Regulation Of ATPase Activity Regulated Secretory Pathway Golgi Vesicle Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Negative Regulation Of Fibril Organization Negative Regulation Of GTP Cyclohydrolase I Activity Establishment Of Protein Localization To Plasma Membrane Cell-cell Signaling Protein Stabilization Positive Regulation Of Calcium:sodium Antiporter Activity Endomembrane System Organization Positive Regulation Of Potassium Ion Import Regulation Of Fibril Organization Protein Localization Secretion By Cell Golgi Reassembly Positive Regulation Of Sodium Ion Export From Cell Regulation Of Protein Stability Regulation Of Neurotransmitter Levels Regulation Of Metabolic Process Protein Transport Into Plasma Membrane Raft Clathrin Coat Disassembly Protein Localization To Plasma Membrane Protein Localization To Plasma Membrane Raft Histamine Secretion By Mast Cell Sodium Ion Export From Cell Establishment Of Golgi Localization Secretion Positive Regulation Of Metabolic Process Sodium Ion Export Golgi Inheritance Regulation Of Catalytic Activity Cellular Potassium Ion Homeostasis Vesicle-mediated Transport Histamine Secretion Transport Protein Transport Into Membrane Raft Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Plasma Membrane Organization Embryonic Process Involved In Female Pregnancy	Response To Tumor Necrosis Factor Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Lung Blood Pressure Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Dihydrobiopterin Metabolic Process Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Tetrahydrofolate Biosynthetic Process Tetrahydrobiopterin Biosynthetic Process Response To Cytokine Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process Dopamine Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Nitric Oxide Biosynthetic Process Negative Regulation Of Histone Methylation Response To Lipid Negative Regulation Of Centrosome Duplication Neuromuscular Process Controlling Posture Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Catecholamine Biosynthetic Process Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Postreplication Repair Positive Regulation Of Protein Acetylation Regulation Of Transcription From RNA Polymerase III Promoter Tetrahydrofolate Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Gene Expression By Genetic Imprinting Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Tagcloud ?		allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val
Tagcloud (Difference) ?		allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val
Tagcloud (Intersection) ?