TINF2 and AFAP1L2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TINF2	AFAP1L2
Gene Name		TERF1 (TRF1)-interacting nuclear factor 2	actin filament associated protein 1-like 2
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix	Cytoplasm Plasma Membrane
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region	Inflammatory Response Regulation Of Mitotic Cell Cycle Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS			Cognitive performance ( 20125193)
Protein-Protein Interactions		88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	9 interactors: ACD APP ATXN1L POT1 RASA1 SRC TERF1 TERF2 TINF2
Entrez ID		26277	84632
HPRD ID		16056	13902
Ensembl ID		ENSG00000092330	ENSG00000169129
Uniprot IDs		B4DFJ1 Q9BSI4	F5GZE1 Q8N4X5
PDB IDs		3BQO 3BU8	2COF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process	Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Assembly Telomere Capping Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Protein Localization To Chromosome, Telomeric Region Positive Regulation Of DNA Metabolic Process Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Organelle Organization Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Biosynthetic Process RNA-dependent DNA Replication Negative Regulation Of Biosynthetic Process Homeostatic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Localization To Chromosome Positive Regulation Of Organelle Organization Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Regulation Of Cellular Component Organization Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Telomerase Activity Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Chromosome Organization Cellular Component Assembly DNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Cellular Metabolic Process Regulation Of Binding Positive Regulation Of Catalytic Activity DNA Replication
Tagcloud ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Difference) ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Intersection) ?