TINF2 and RGS14

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TINF2	RGS14
Gene Name		TERF1 (TRF1)-interacting nuclear factor 2	regulator of G-protein signaling 14
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Plasma Membrane Postsynaptic Density Nuclear Body PML Body Cell Junction Dendrite Dendritic Spine Postsynaptic Membrane
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	G-protein Alpha-subunit Binding Receptor Signaling Protein Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Microtubule Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity GTPase Activating Protein Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region	Nucleocytoplasmic Transport Response To Oxidative Stress Spindle Organization Chromosome Segregation Mitotic Nuclear Division Learning Long-term Memory Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Visual Learning Zygote Asymmetric Cell Division Negative Regulation Of Synaptic Plasticity Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Regulation Of DNA-templated Transcription In Response To Stress Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurogenesis Cell Division Long-term Synaptic Potentiation Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Multiple sclerosis ( 21833088) Nephrolithiasis ( 22396660) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727)
Protein-Protein Interactions		88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	15 interactors: APP GNA11 GNAI1 GNAI2 GNAI3 GNAO1 NFKB1 POT1 PRKACA RAP1A RAP2A TINF2 TRAF2 WAS XPO1
Entrez ID		26277	10636
HPRD ID		16056	03944
Ensembl ID		ENSG00000092330	ENSG00000169220
Uniprot IDs		B4DFJ1 Q9BSI4	B3KUX0 O43566
PDB IDs		3BQO 3BU8	2JNU 2OM2 2XNS 3ONW 3QI2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process	Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Catalytic Activity Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Response To Stress Signaling Cell Communication Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Cellular Response To Stimulus Negative Regulation Of Catalytic Activity Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Telomere Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cyclase Activity Negative Regulation Of Cellular Metabolic Process Rap Protein Signal Transduction Negative Regulation Of Telomere Maintenance Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Activation Of Protein Kinase Activity Regulation Of CAMP Biosynthetic Process Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Difference) ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Intersection) ?