SLC35A3 and CRADD

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SLC35A3	CRADD
Gene Name		solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3	CASP2 and RIPK1 domain containing adaptor with death domain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Integral Component Of Membrane	Nucleus Cytoplasm
	Molecular Function	Sugar:proton Symporter Activity UDP-N-acetylglucosamine Transmembrane Transporter Activity Protein Binding	Protease Binding Protein Binding Protein Binding, Bridging Death Domain Binding
	Biological Process	UDP-N-acetylglucosamine Metabolic Process Carbohydrate Transport UDP-N-acetylglucosamine Transport Proton Transport Transmembrane Transport UDP-N-acetylglucosamine Transmembrane Transport	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Transport of nucleotide sugars Transport of vitamins, nucleosides, and related molecules SLC-mediated transmembrane transport
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Height ( 18391951)
Protein-Protein Interactions		2 interactors: CRADD TP63	18 interactors: APP APPL2 BBS5 C14orf1 CASP2 CASP8 CCSER2 DCXR EEF1A1 IL9R KCTD9 KPNA1 LRIF1 PIDD1 RIPK1 SLC35A3 TRIM54 VTN
Entrez ID		23443	8738
HPRD ID		10413	04584
Ensembl ID		ENSG00000117620	ENSG00000169372
Uniprot IDs		Q9BSB7 Q9Y2D2	F5H7C2 P78560 Q53XL1
PDB IDs			2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?		Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Ectoderm And Mesoderm Interaction Epidermal Cell Division Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Positive Regulation Of Cell Cycle Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Apoptotic Signaling Pathway Regulation Of Epidermal Cell Division Regulation Of Endopeptidase Activity Regulation Of Mitotic Cell Cycle Regulation Of Peptidase Activity Female Genitalia Morphogenesis Negative Regulation Of Cell Cycle Cloacal Septation Urinary Bladder Development Regulation Of Cell Cycle Process Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Prostatic Bud Formation Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Replicative Cell Aging Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Regulation Of Proteolysis	Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Execution Phase Of Apoptosis Protein Processing Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Differentiation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of Proteolysis Extrinsic Apoptotic Signaling Pathway Zymogen Activation Programmed Cell Death Cell Death Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Copper Ion Homeostasis Positive Regulation Of Cysteine-type Endopeptidase Activity Sterol Metabolic Process Regulation Of Necrotic Cell Death Positive Regulation Of Endopeptidase Activity Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Binding Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Oligomerization Mating Behavior Regulation Of Extrinsic Apoptotic Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Positive Regulation Of Myeloid Leukocyte Differentiation Mating Interleukin-9-mediated Signaling Pathway Regulation Of ATP:ADP Antiporter Activity Positive Regulation Of Apoptotic Process Steroid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Programmed Cell Death Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Tagcloud ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled sqrdl transcriptomic xenobiotic	bcap31 bcl2l13 bnipl card4 casp2 casp8 cd25 cd69 churg css defect eosinophil eosinophilia eosinophils exacerbation granuloma ikbkb ikbke immunophenotype intrinsic necrotizing proapoptotic pycard rel spontaneous strauss transcriptome vasculitis wondered
Tagcloud (Difference) ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled sqrdl transcriptomic xenobiotic	bcap31 bcl2l13 bnipl card4 casp2 casp8 cd25 cd69 churg css defect eosinophil eosinophilia eosinophils exacerbation granuloma ikbkb ikbke immunophenotype intrinsic necrotizing proapoptotic pycard rel spontaneous strauss transcriptome vasculitis wondered
Tagcloud (Intersection) ?