CRADD and IL9R

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CRADD	IL9R
Gene Name		CASP2 and RIPK1 domain containing adaptor with death domain	interleukin 9 receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Space Integral Component Of Plasma Membrane
	Molecular Function	Protease Binding Protein Binding Protein Binding, Bridging Death Domain Binding	Interleukin-9 Receptor Activity Interleukin-9 Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Signaling Pathway	Signal Transduction Cell Proliferation Positive Regulation Of Cell Growth Interleukin-9-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Height ( 18391951)
Protein-Protein Interactions		18 interactors: APP APPL2 BBS5 C14orf1 CASP2 CASP8 CCSER2 DCXR EEF1A1 IL9R KCTD9 KPNA1 LRIF1 PIDD1 RIPK1 SLC35A3 TRIM54 VTN	6 interactors: CRADD IL2RG IL9 JAK1 KAT5 YWHAZ
Entrez ID		8738	3581
HPRD ID		04584	02052
Ensembl ID		ENSG00000169372	ENSG00000124334
Uniprot IDs		F5H7C2 P78560 Q53XL1	Q01113
PDB IDs		2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?		Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Execution Phase Of Apoptosis Protein Processing Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Differentiation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of Proteolysis Extrinsic Apoptotic Signaling Pathway Zymogen Activation Programmed Cell Death Cell Death Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Copper Ion Homeostasis Positive Regulation Of Cysteine-type Endopeptidase Activity Sterol Metabolic Process Regulation Of Necrotic Cell Death Positive Regulation Of Endopeptidase Activity Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Binding Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Oligomerization Mating Behavior Regulation Of Extrinsic Apoptotic Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Positive Regulation Of Myeloid Leukocyte Differentiation Mating Interleukin-9-mediated Signaling Pathway Regulation Of ATP:ADP Antiporter Activity Positive Regulation Of Apoptotic Process Steroid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Programmed Cell Death Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint	Interleukin-2-mediated Signaling Pathway Response To Interleukin-2 Immune Response DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Positive Regulation Of Interleukin-5 Biosynthetic Process Signal Transduction By P53 Class Mediator Response To Stress Interleukin-7-mediated Signaling Pathway Intracellular Signal Transduction Immune System Process Golgi Reassembly Positive Regulation Of Apoptotic Signaling Pathway Histamine Secretion By Mast Cell Establishment Of Golgi Localization Response To Stimulus Golgi Inheritance Histamine Secretion Positive Regulation Of Protein Metabolic Process Signal Transduction Histamine Transport Interleukin-4-mediated Signaling Pathway Apoptotic Signaling Pathway Defense Response DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Signaling Golgi Localization Cell Communication Positive Regulation Of Interleukin-5 Production Inflammatory Response Cellular Response To Estradiol Stimulus Mast Cell Degranulation Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-2 Production Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Mast Cell Mediated Immunity Positive Regulation Of Protein Acetylation Regulation Of Interleukin-5 Production Lysosome Localization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cytokine Production Mast Cell Activation Cellular Response To Estrogen Stimulus Viral Process Cellular Response To Stimulus Cellular Response To Organic Substance
Tagcloud ?		bcap31 bcl2l13 bnipl card4 casp2 casp8 cd25 cd69 churg css defect eosinophil eosinophilia eosinophils exacerbation granuloma ikbkb ikbke immunophenotype intrinsic necrotizing proapoptotic pycard rel spontaneous strauss transcriptome vasculitis wondered	augment bifunctional biopharmaceutical borne clustering designer desirable door engineered fusokine fusokines gift9 gmcsf gmcsfr granulocyte hereafter heretofore heterologous jak1 jak3 notion opens pharmaceutical therapeutically transhyperphosphorylation translates transphosphorylation unrealized
Tagcloud (Difference) ?		bcap31 bcl2l13 bnipl card4 casp2 casp8 cd25 cd69 churg css defect eosinophil eosinophilia eosinophils exacerbation granuloma ikbkb ikbke immunophenotype intrinsic necrotizing proapoptotic pycard rel spontaneous strauss transcriptome vasculitis wondered	augment bifunctional biopharmaceutical borne clustering designer desirable door engineered fusokine fusokines gift9 gmcsf gmcsfr granulocyte hereafter heretofore heterologous jak1 jak3 notion opens pharmaceutical therapeutically transhyperphosphorylation translates transphosphorylation unrealized
Tagcloud (Intersection) ?