FLNA and SIGLEC10

Number of citations of the paper that reports this interaction (PMID 12055638)
25

Data Source:
HPRD (two hybrid)

		FLNA	SIGLEC10
Gene Name		filamin A, alpha	sialic acid binding Ig-like lectin 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Cortical Cytoskeleton Myb Complex Neuronal Cell Body Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Apical Dendrite	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	Glycoprotein Binding Signal Transducer Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding Ral GTPase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Poly(A) RNA Binding SMAD Binding Rac GTPase Binding Actin Filament Binding	Carbohydrate Binding
	Biological Process	Epithelial To Mesenchymal Transition Platelet Degranulation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation Platelet Activation Actin Cytoskeleton Reorganization Cell Junction Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Cilium Assembly MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Factor Import Into Nucleus Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Early Endosome To Late Endosome Transport Establishment Of Protein Localization Protein Stabilization Cytoplasmic Sequestering Of Protein Actin Crosslink Formation Platelet Aggregation Mitotic Spindle Assembly	Cell Adhesion
Pathways		Cell junction organization GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		82 interactors: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DRD1 DRD2 DRD3 ERBB3 F3 FABP1 FAM101A FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HNRNPD HSPB7 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MTNR1A MTNR1B MYOT NPHP1 OPRM1 PAK1 PCBP2 PRKCA PSEN1 PSEN2 RAC1 RALA REL RHOA SELE SH2B3 SHBG SIGLEC10 SMAD3 SMAD5 SRC SVIL SYNPO2 TCF4 TLR10 TNIP2 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG	2 interactors: FLNA PTPN6
Entrez ID		2316	89790
HPRD ID		02060	07307
Ensembl ID		ENSG00000196924	ENSG00000142512
Uniprot IDs		P21333 Q60FE5 Q6NXF2	B7ZL06 E9PL79 Q96LC7
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH
Enriched GO Terms of Interacting Partners?		Signal Transduction Cellular Response To Stimulus Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Stress Regulation Of Phosphorus Metabolic Process Wound Healing Response To Wounding Regulation Of Signaling Positive Regulation Of Signal Transduction Response To Organic Substance Positive Regulation Of Metabolic Process Response To External Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Apoptotic Process Response To Abiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Anatomical Structure Development Positive Regulation Of Phosphorylation Tissue Development Blood Coagulation Hemostasis Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Multicellular Organismal Development System Development Cellular Response To Organic Substance Regulation Of Apoptotic Process Developmental Process	Platelet Aggregation Platelet Activation Abortive Mitotic Cell Cycle Homotypic Cell-cell Adhesion Blood Coagulation Hemostasis Regulation Of Intracellular Transport Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Single Organismal Cell-cell Adhesion Regulation Of Body Fluid Levels Wound Healing Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Cell Activation Response To Wounding Cell Morphogenesis Involved In Differentiation MRNA Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle MRNA Transcription Positive Regulation Of Intracellular Signal Transduction Megakaryocyte Development Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Protein Metabolic Process Protein Localization To Cell Surface Mitotic Spindle Assembly Early Endosome To Late Endosome Transport Negative Regulation Of T Cell Receptor Signaling Pathway Platelet Formation Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Megakaryocyte Differentiation Actin Crosslink Formation Regulation Of Cellular Localization Natural Killer Cell Mediated Cytotoxicity Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Growth Hormone Receptor Signaling Pathway Cytoplasmic Sequestering Of Protein Natural Killer Cell Mediated Immunity Cellular Response To Growth Hormone Stimulus G-protein Coupled Receptor Signaling Pathway Regulation Of B Cell Differentiation Cell Adhesion Leukocyte Mediated Cytotoxicity Positive Regulation Of Signal Transduction Dopamine Receptor Signaling Pathway Negative Regulation Of Adaptive Immune Response
Tagcloud ?		actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles	c1qr c1qr1 c3ar c3ar1 cd114 cd115 cd16 cd1d cd43 cd93 cd97 cdkn1c csf1r csf3r cx3cr1 fcgammariii fpr1 gcsfr hmox1 ifitm1 lst1 mafb mgll mnda mphi mtss1 tnfrsf8 trem1 wars
Tagcloud (Difference) ?		actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles	c1qr c1qr1 c3ar c3ar1 cd114 cd115 cd16 cd1d cd43 cd93 cd97 cdkn1c csf1r csf3r cx3cr1 fcgammariii fpr1 gcsfr hmox1 ifitm1 lst1 mafb mgll mnda mphi mtss1 tnfrsf8 trem1 wars
Tagcloud (Intersection) ?