IKZF3 and RBBP8

Number of citations of the paper that reports this interaction (PMID 12015313)
17

Data Source:
HPRD (in vivo)

		IKZF3	RBBP8
Gene Name		IKAROS family zinc finger 3 (Aiolos)	retinoblastoma binding protein 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Nucleolus Transcriptional Repressor Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity	Single-stranded DNA Endodeoxyribonuclease Activity RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Damaged DNA Binding Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Mesoderm Development Regulation Of B Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Regulation Of B Cell Differentiation Regulation Of Lymphocyte Differentiation	Cell Cycle Checkpoint G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic Blastocyst Hatching DNA Repair Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Nuclear Division DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing G2 DNA Damage Checkpoint Cell Division Meiotic Cell Cycle
Pathways			Meiotic recombination
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Primary biliary cirrhosis ( 19458352 23000144 20639880) Rheumatoid arthritis ( 20453842) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Ulcerative colitis ( 21297633)	Height ( 18391951) Intracranial aneurysm ( 20364137) Tuberculosis ( 20694014)
Protein-Protein Interactions		71 interactors: ABLIM3 AES AKAP9 AQP1 ARMC7 ARNT2 ATPAF2 BCAS2 BCL2L1 C1orf109 CABP5 CDKN1A CDKN2D CHCHD2 CHD3 DGCR6 EFHC1 EMC2 EXOC8 EXOSC5 FANCL FARS2 FBF1 GEM GRB2 HNRNPF HRAS IKZF1 IKZF4 IKZF5 ING5 KAT5 KRT19 LGALS14 LMO1 LMO2 MAGOHB MORN3 MRPL28 MRPL53 NATD1 NEK6 OAZ3 OSGIN1 PCID2 PFDN5 PIK3R2 PIN1 POLM POLR1C PPP1R16B PRKAA1 PRKAB2 PSMA1 RAD51D RBBP8 RCOR3 RHOA SPG21 STAMBPL1 STK16 STX11 TBC1D22B TCAF1 TEKT4 TRAPPC6A TRIM42 TSSK3 TSTD2 UBE2I ZGPAT	34 interactors: ATM BARD1 BRCA1 CLU CTBP1 CTBP2 EEF1A1 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 LIMS1 LMO1 LMO2 LMO4 MAP2K4 MRE11A PCNA PIN1 PRKDC PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 SIAH1 SIAH2 TGIF2 TMEM54 WDYHV1
Entrez ID		22806	5932
HPRD ID		05869	04990
Ensembl ID			ENSG00000101773
Uniprot IDs		Q9UKT9	Q99708
PDB IDs			2L4Z
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Organelle Organization Gene Expression Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Radiation Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Cellular Response To Organonitrogen Compound Response To Hormone Nucleobase-containing Compound Metabolic Process Cell Cycle Checkpoint RNA Metabolic Process Response To Ionizing Radiation Cell Cycle Arrest Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Immune System Process Response To Stress Nitrogen Compound Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Hormone Stimulus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Signaling Ammonium Transmembrane Transport Biosynthetic Process Macromolecule Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Organic Substance Response To Organonitrogen Compound	Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process G2 DNA Damage Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Cell Death Cell Cycle Checkpoint Regulation Of Nucleic Acid-templated Transcription Programmed Cell Death Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Phosphorylation Cell Death Negative Regulation Of Gene Expression Death Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Protein Modification Process Telomere Maintenance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Immune System Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Double-strand Break Repair Via Homologous Recombination Recombinational Repair
Tagcloud ?		17q12 amplicon cab2 ccct darpp32 endued gc han haplotype histogenesis immumohistochemical implied per1 perld1 ppp1r1b q21 rs11869286 rs1877031 rs881844 rs9972882 sequenom signet stard3 steroidogenic tcap titin tma top2a znfn1a3	advance breaks cluster ctip doi downregulates downregulating dsbs elusive faithful genotoxic hypersensitivity impairs mechanistic microrna mir october onc oncogenic oncomir online polycistronic publication recombination repressed resection strand suppresses untranslated
Tagcloud (Difference) ?		17q12 amplicon cab2 ccct darpp32 endued gc han haplotype histogenesis immumohistochemical implied per1 perld1 ppp1r1b q21 rs11869286 rs1877031 rs881844 rs9972882 sequenom signet stard3 steroidogenic tcap titin tma top2a znfn1a3	advance breaks cluster ctip doi downregulates downregulating dsbs elusive faithful genotoxic hypersensitivity impairs mechanistic microrna mir october onc oncogenic oncomir online polycistronic publication recombination repressed resection strand suppresses untranslated
Tagcloud (Intersection) ?