ETS1 and ETS2

Number of citations of the paper that reports this interaction (PMID 9334186)
21

Data Source:
HPRD (in vitro)

		ETS1	ETS2
Gene Name		v-ets avian erythroblastosis virus E26 oncogene homolog 1	v-ets avian erythroblastosis virus E26 oncogene homolog 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Intercellular Bridge	Nucleus Nucleoplasm
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Glucocorticoid Receptor Binding
	Biological Process	Response To Hypoxia Transcription From RNA Polymerase II Promoter Immune Response Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Mechanical Stimulus Positive Regulation Of Endothelial Cell Migration Regulation Of Extracellular Matrix Disassembly Hypothalamus Development Pituitary Gland Development PML Body Organization Response To Estradiol Response To Laminar Fluid Shear Stress Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Antibiotic Cell Motility Positive Regulation Of Cellular Component Movement Angiogenesis Involved In Wound Healing Cellular Response To Hydrogen Peroxide Response To Interleukin-1	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Cellular Senescence Oncogene Induced Senescence	Cellular Senescence Oncogene Induced Senescence
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 22446963) Systemic lupus erythematosus ( 23273568 20169177 19838193)	Non-small cell lung cancer ( 21079520)
Protein-Protein Interactions		47 interactors: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 C17orf62 CAMK2A CAMK2B CREBBP DAXX EIF5B EP300 ETS2 FOS GATA3 HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PAX5 POU1F1 RBBP6 RFWD2 RPL13A RUNX1 RUNX1T1 RUNX2 SMAD3 SP1 SP100 SPI1 SRA1 SRC SRSF11 STAT5B STAT6 TDP2 UBE2I	20 interactors: CDK10 CREBBP EP300 ERG ETS1 FOS GATA3 JUN NCOR1 NR3C1 POU5F1 RFWD2 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 ZFYVE9 ZMYND11
Entrez ID		2113	2114
HPRD ID		01260	01263
Ensembl ID		ENSG00000134954	ENSG00000157557
Uniprot IDs		A8K725 B4DW78 P14921	P15036
PDB IDs		1GVJ 2NNY 2STT 2STW 3MFK 3RI4	4BQA 4MHV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Gene Expression RNA Metabolic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Immune System Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Heterocycle Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Innate Immune Response Biosynthetic Process Developmental Process Cell Differentiation Cellular Metabolic Process Cellular Response To Organic Substance Immune Response Cellular Response To Growth Factor Stimulus Multicellular Organismal Development Response To Growth Factor System Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Abiotic Stimulus Anatomical Structure Development Tissue Development Toll-like Receptor 5 Signaling Pathway	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Cell Cycle Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Myeloid Cell Differentiation Positive Regulation By Host Of Viral Transcription Response To Steroid Hormone Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Signaling Gland Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Nitrogen Compound Metabolic Process Response To Lipid Biosynthetic Process Leukocyte Differentiation Immune System Process Cellular Response To Growth Factor Stimulus Regulation Of Myeloid Cell Differentiation Response To Organic Cyclic Compound Tissue Development
Tagcloud ?		acetate ap1 avian began belong cooperative counterpart differentiate erbb erythroblastosis erythrocytic gata glycoproteins h5 homologues jb jbn jun mammal megakaryocytes megakaryocytic myristate oncogenes phorbol retroviruses thrombocytes thrombocytic transform transformed	3t3 activates ap blocked colony confirming constitutive cotransfected cotransfection dominant downstream erbb families focus mutants neu neut nih oncogenic parallel points raf ras reporter residue threonine transforming transmembrane
Tagcloud (Difference) ?		acetate ap1 avian began belong cooperative counterpart differentiate erythroblastosis erythrocytic gata glycoproteins h5 homologues jb jbn jun mammal megakaryocytes megakaryocytic myristate oncogenes phorbol retroviruses thrombocytes thrombocytic transform transformed	3t3 activates ap blocked colony confirming constitutive cotransfected cotransfection dominant downstream families focus mutants neu neut nih oncogenic parallel points raf ras reporter residue threonine transforming transmembrane
Tagcloud (Intersection) ?		erbb