ESR2 and WIPI1

Number of citations of the paper that reports this interaction (PMID 15602573)
61

Data Source:
HPRD (in vitro)

		ESR2	WIPI1
Gene Name		estrogen receptor 2 (ER beta)	WD repeat domain, phosphoinositide interacting 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Mitochondrion	Golgi Membrane Pre-autophagosomal Structure Autophagic Vacuole Membrane Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Endosome Membrane Extrinsic Component Of Membrane Clathrin-coated Vesicle Pre-autophagosomal Structure Membrane
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding Estrogen Receptor Activity Estrogen Response Element Binding Receptor Antagonist Activity	Receptor Binding Estrogen Receptor Binding Phosphatidylinositol-3-phosphate Binding Androgen Receptor Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovarian Follicle Development Neuron Migration Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Brain Development Hormone-mediated Apoptotic Signaling Pathway Gene Expression Negative Regulation Of Cell Growth Intracellular Estrogen Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Uterus Development Vagina Development Prostate Gland Epithelium Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Negative Regulation Of Androgen Receptor Signaling Pathway Extracellular Negative Regulation Of Signal Transduction	Autophagic Vacuole Assembly Mitochondrion Degradation Protein Lipidation Autophagy Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Unfolded Protein Response Protein Localization To Pre-autophagosomal Structure Cellular Protein Metabolic Process Nucleophagy Vesicle Targeting, Trans-Golgi To Endosome
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs		Diethylstilbestrol Raloxifene Tamoxifen Estradiol Trilostane Estramustine Genistein Para-Mercury-Benzenesulfonic Acid N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide 5-Alpha-Androstane-3-Beta,17beta-Diol 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol Estriol Estropipate 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
Diseases
GWAS
Protein-Protein Interactions		88 interactors: AKAP13 AKT1 ARID5A BCAS2 CALM1 CALM2 CALM3 CCNC CDK8 DAP3 DDX17 DDX5 DDX54 DNTTIP2 EIF3I EP300 ESR1 JMJD1C KAT5 LCK MAD2L1 MAPK1 MAPK11 MED1 MED10 MED12 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED6 MED7 MEOX2 MKNK2 MMS19 MSH2 NCOA1 NCOA2 NCOA3 NCOA6 NCOA7 NCOR1 NCOR2 NFKBIB NOTCH2NL NR0B1 NR0B2 NRIP1 OXT PELP1 PIAS1 PIAS2 PIAS3 PLSCR1 PNRC1 PNRC2 PPARG PPARGC1A PPP5C PRMT2 PSMC3IP RBFOX2 RBM39 REXO4 RFX6 RXRA SERPINH1 SMAD2 SMAD3 SMAD4 SMARCE1 SP1 SRA1 SRC SREBF1 STAT5A TRAM1 TRIM24 TRIM59 TRIP4 WIPI1 YWHAH YWHAQ ZBTB17 ZNHIT3	5 interactors: AR ESR1 ESR2 KCTD15 PPA1
Entrez ID		2100	55062
HPRD ID		03390	08540
Ensembl ID		ENSG00000140009	ENSG00000070540
Uniprot IDs		F1D8N3 G3V5M5 Q0PTK2 Q7LCB3 Q92731	G5EA37 Q5MNZ9
PDB IDs		1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL 3OLS 3OMO 3OMP 3OMQ 4J24 4J26
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Androgen Receptor Signaling Pathway Response To Organic Substance Cellular Metabolic Process Cellular Response To Organic Substance Response To Hormone Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Response To Steroid Hormone Response To Organic Cyclic Compound Metabolic Process Regulation Of Signaling Cellular Response To Hormone Stimulus Developmental Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process	Intracellular Steroid Hormone Receptor Signaling Pathway Prostate Gland Development Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Vagina Development Uterus Development Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Estrogen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Female Genitalia Development DNA-templated Transcription, Initiation Sex Differentiation Prostate Gland Epithelium Morphogenesis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Prostate Gland Morphogenesis Urogenital System Development Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Genitalia Development Response To Steroid Hormone Ovarian Follicle Development Gland Development Reproductive Structure Development Reproductive System Development Cellular Response To Hormone Stimulus Ovulation Cycle Process Female Gonad Development Negative Regulation Of Integrin Biosynthetic Process Ovulation Cycle Development Of Primary Female Sexual Characteristics Developmental Process Involved In Reproduction Diphosphate Metabolic Process Response To Lipid Gland Morphogenesis Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Hormone Positive Regulation Of Integrin Biosynthetic Process Prostate Epithelial Cord Elongation Epithelial Cell Development Regulation Of Integrin Biosynthetic Process Negative Regulation Of Signal Transduction Gonad Development Development Of Primary Sexual Characteristics Epithelial Cell Maturation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hormone-mediated Apoptotic Signaling Pathway
Tagcloud ?		25mg acrosomes bisphenol bpa compromises disrupts dosages epididymis esr1 fsh fshb gnrhr gonadal gonadotropin hypogonadism hypogonadotropic hypothalamic lh lhb luteinizing nontoxic pituitary reestablish reproductive reserves sperm spermatogenesis spermatozoa transit	28c atg16l autophagic autophagosome autophagy carbonyl coa desaturase dimethylamino earliest immunoblot lc3 microscopic n2 n5 oleic p62 puncta pyridinedicarboxamide rapamycin scd scd1 sqstm1 starvation stearoyl structurally thiazolyl ulk1 unsaturated
Tagcloud (Difference) ?		25mg acrosomes bisphenol bpa compromises disrupts dosages epididymis esr1 fsh fshb gnrhr gonadal gonadotropin hypogonadism hypogonadotropic hypothalamic lh lhb luteinizing nontoxic pituitary reestablish reproductive reserves sperm spermatogenesis spermatozoa transit	28c atg16l autophagic autophagosome autophagy carbonyl coa desaturase dimethylamino earliest immunoblot lc3 microscopic n2 n5 oleic p62 puncta pyridinedicarboxamide rapamycin scd scd1 sqstm1 starvation stearoyl structurally thiazolyl ulk1 unsaturated
Tagcloud (Intersection) ?