EGFR and HSPA1A

Number of citations of the paper that reports this interaction (PMID 20029029)
27

Data Source:
BioGRID (protein complementation assay)

		EGFR	HSPA1A
Gene Name		epidermal growth factor receptor	heat shock 70kDa protein 1A
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Space Nucleus Cytoplasm Endosome Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Cell Surface Endosome Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Nuclear Membrane Receptor Complex Membrane Raft Perinuclear Region Of Cytoplasm Shc-EGFR Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centriole Cytosol Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Ribonucleoprotein Complex Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Glycoprotein Binding Chromatin Binding Double-stranded DNA Binding MAP Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Epidermal Growth Factor-activated Receptor Activity Integrin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Nitric-oxide Synthase Regulator Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Heterodimerization Activity Epidermal Growth Factor Binding Actin Filament Binding	Virus Receptor Activity G-protein Coupled Receptor Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Poly(A) RNA Binding Protein N-terminus Binding Unfolded Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Ossification Liver Development Embryonic Placenta Development Positive Regulation Of Protein Phosphorylation Hair Follicle Development Translation Response To Stress Response To Osmotic Stress Response To Oxidative Stress Signal Transduction Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Axon Guidance Salivary Gland Morphogenesis Learning Or Memory Circadian Rhythm Cell Proliferation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Magnesium Ion Homeostasis Diterpenoid Metabolic Process Single Organismal Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Alkanesulfonate Metabolic Process Cerebral Cortex Cell Migration Lung Development Positive Regulation Of Cell Migration Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Response To Cobalamin Response To Hydroxyisoflavone Positive Regulation Of Catenin Import Into Nucleus Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Positive Regulation Of Phosphorylation Ovulation Cycle Hydrogen Peroxide Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Tongue Development Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Astrocyte Activation Positive Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Nitric-oxide Synthase Activity Protein Insertion Into Membrane Response To Calcium Ion Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Synaptic Transmission, Glutamatergic Morphogenesis Of An Epithelial Fold Response To UV-A Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Dexamethasone Stimulus	MRNA Catabolic Process Response To Unfolded Protein Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Protein Ubiquitination Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Protein Stabilization Negative Regulation Of Cell Death Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K/AKT activation PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Signaling by PDGF EGFR downregulation DAP12 interactions GAB1 signalosome GRB2 events in EGFR signaling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Adaptive Immune System Axon guidance PIP3 activates AKT signaling L1CAM interactions EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signalling by NGF Signal transduction by L1 Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Inhibition of Signaling by Overexpressed EGFR Signaling by FGFR SHC1 events in EGFR signaling Constitutive Signaling by EGFRvIII	Regulation of mRNA stability by proteins that bind AU-rich elements Viral RNP Complexes in the Host Cell Nucleus Attenuation phase Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA Influenza Infection Influenza Life Cycle HSF1-dependent transactivation Export of Viral Ribonucleoproteins from Nucleus
Drugs		Cetuximab Trastuzumab Lidocaine Gefitinib Erlotinib Lapatinib Panitumumab Flavopiridol Vandetanib S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE Afatinib
Diseases
GWAS		Glioma ( 21531791)
Protein-Protein Interactions		279 interactors: ABL1 ABL2 ACTA1 ADRBK1 ADRM1 AGTR1 AHNAK AHSA1 AIP AKAP12 ALCAM ALDOA AMH ANKS1A ANKS1B ANXA1 APBA3 APBB1 APBB2 APBB3 APPL1 AR AREG ARF4 ATIC ATP1A1 ATP1B1 ATP5C1 BLK BMX BTC CALM1 CALM2 CALM3 CAMK2A CAMK2G CAMLG CASP1 CAV1 CAV2 CAV3 CBL CBLB CBLC CBR1 CD44 CD59 CD82 CDC25A CDH1 CEACAM1 CEBPB CEND1 CFL1 CISH CLNK CLTA CLTCL1 CMTM8 CNTN2 COL9A3 COX2 CRK CSRP1 CTNNB1 CTNND1 DCBLD2 DCN DCTN2 DEGS1 DNAJC4 DOK2 DOK4 DOK5 DOK6 DUSP3 DYNC1H1 EEF1G EGF ELF3 EPB41 EPHA2 EPPK1 EPS15 EPS8 ERBB2 ERBB3 ERBB4 EREG ERRFI1 ESR1 EZR FAH FAS FBXO25 FER FES FKBP4 FKBP8 FN1 GAB1 GABARAPL2 GAPDH GNAI2 GOT1 GPM6B GRB10 GRB14 GRB2 GRB7 HBEGF HEXIM1 HGS HIST3H3 HOXC10 HSP90B1 HSPA1A HSPA4 HSPA8 HTT ICAM1 INPPL1 IRS1 IRS4 ITGA5 JAK2 JUP KCTD9P2 KRT17 KRT18 KRT7 KRT8 LYN MAP2K1 MAP3K12 MAP3K14 MAP4K1 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAST1 MATR3 MDH1 MEGF6 MET MGARP MOB4 MUC1 NCAM1 NCK1 NCK2 NDN NEDD4 NUMB NUMBL OAZ1 OLFM1 PAK1 PCNA PDCD6IP PDGFRB PDK3 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PIN4 PITPNA PKIA PLCG1 PLCG2 PLD1 PLD2 PLEC PLSCR1 PML PPP5C PRCC PRDX1 PRKACA PRKAR1A PRKAR1B PRKCA PRKCB PRKCD PRKD1 PSMA7 PSMD4 PTGDS PTK2 PTK2B PTK6 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRJ PTPRS RAB3A RAP1GDS1 RASA1 RGS16 RIN2 RIPK1 RNF115 RNF126 RQCD1 RUSC2 S100A7 S100A9 SCAMP1 SCAMP3 SEC13 SEPP1 SFN SGSM2 SH2B1 SH2B3 SH2D1A SH2D2A SH2D3A SH3BGRL3 SHC1 SHC2 SHC3 SLA SLC3A2 SLC9A3R1 SMURF2 SNRPD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS3 SOCS4 SOCS5 SOCS7 SORBS2 SOS1 SOS2 SPARCL1 SPCS2 SRC STAM2 STAT1 STAT3 STAT5A STAT5B STIP1 SYK TGFA TJP1 TLN1 TMCO3 TNC TNK2 TNS4 TPI1 TPM1 TRPV1 TUBA1A TUBA4A UBB UBE2V2 UCHL1 UROD VAPA VAV1 VAV2 VAV3 XRCC6 YWHAZ ZAP70 ZPR1	79 interactors: AIFM1 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJC3 DNAJC7 DYX1C1 EGFR EIF2AK2 FANCC FOS GPR37 GRIN1 GRIN2D HCFC1 HIVEP1 HMGA1 HSBP1 HSF1 HSP90AA1 HSPA8 HSPBP1 IKBKG KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 PEX5 PLG POT1 PPP1R15A PRKCA PTGES3 PTMA RAP1A RAPGEF2 RHOA SAE1 SLC5A1 SNCA SNCB SNRK SOX9 ST13 STIP1 STUB1 TCERG1 TGM2 TOMM70A TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		1956	3303
HPRD ID		00579	00774
Ensembl ID		ENSG00000146648	ENSG00000204389
Uniprot IDs		E9PFD7 P00533	A8K5I0 B3KTT5 P08107
PDB IDs		1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2EB2 2EB3 2EXP 2EXQ 2GS2 2GS6 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F 2J6M 2JIT 2JIU 2JIV 2KS1 2M20 2RF9 2RFD 2RFE 2RGP 3B2U 3B2V 3BEL 3BUO 3C09 3G5V 3G5Y 3GOP 3GT8 3IKA 3LZB 3NJP 3OB2 3OP0 3P0Y 3PFV 3POZ 3QWQ 3UG1 3UG2 3VJN 3VJO 3VRP 3VRR 3W2O 3W2P 3W2Q 3W2R 3W2S 3W32 3W33 4G5J 4G5P 4HJO 4I1Z 4I20 4I21 4I22 4I23 4I24 4JQ7 4JQ8 4JR3 4JRV 4KRL 4KRM 4KRO 4KRP 4LI5 4LL0	1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4J8F
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organic Substance Regulation Of Signal Transduction Response To Stress Cellular Response To Stimulus Cell Communication Cellular Response To Organic Substance Signaling Signal Transduction Innate Immune Response Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Defense Response Wound Healing Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Immune System Process Regulation Of Catalytic Activity Response To Wounding Intracellular Signal Transduction Immune Response Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Neurotrophin TRK Receptor Signaling Pathway Locomotion Regulation Of Protein Phosphorylation Movement Of Cell Or Subcellular Component Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound System Development Response To Organonitrogen Compound Regulation Of Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Anatomical Structure Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Cellular Response To Peptide	Protein Refolding Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Protein Folding Chaperone Cofactor-dependent Protein Refolding Response To Organic Substance Cellular Response To Stimulus Response To Stress Signaling Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Cell Communication Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Signal Transduction Regulation Of Cellular Component Organization Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Negative Regulation Of Biosynthetic Process Apoptotic Signaling Pathway Apoptotic Process
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Intersection) ?