DHX9 and POLR2A

Number of citations of the paper that reports this interaction (PMID 11149922)
46

Data Source:
HPRD (in vivo)

		DHX9	POLR2A
Gene Name		DEAH (Asp-Glu-Ala-His) box helicase 9	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex	Prp19 Complex Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Nucleolus
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding RNA Helicase Activity ATP-dependent DNA Helicase Activity ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding	RNA Polymerase II Activity DNA Binding DNA-directed RNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing Circadian Rhythm RNA Splicing Gene Expression Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Cellular Response To Heat Innate Immune Response CRD-mediated MRNA Stabilization	MRNA Splicing, Via Spliceosome Transcription, RNA-templated DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process Positive Regulation Of RNA Splicing PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription
Pathways		mRNA Splicing Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Processing of Capped Intron-Containing Pre-mRNA TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA mRNA Splicing - Major Pathway MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex	RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DDX5 EIF2AK2 EWSR1 GEMIN2 GEMIN4 GTF2B H2AFX HDLBP HNRNPC HNRNPK IL7R ILF3 JUN KHDRBS1 MBD2 MGEA5 NXF1 PCNA POLR2A PRMT1 PRPF40A PRPF8 RBM4 RELA SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A UBE2I YWHAQ	100 interactors: ABL1 ACTB ACTL6A ATM BARD1 BRCA1 CASP10 CCNH CCNK CCNL2 CCNT1 CDC14A CDK12 CDK7 CDK8 CDK9 CPSF1 CPSF2 CPSF3 CREBBP CSH2 CSNK2A1 CSTF1 CSTF2 CTCF CTD CTDP1 CTDSP1 CTDSP2 DHX9 ELL ERCC5 ERCC6 ERG FCP1 FUS GRB2 GTF2B GTF2E1 GTF2H4 HIST1H1C HNRNPF HNRNPU HTATSF1 ITCH IWS1 KAT2B KLK2 KMT2D LEO1 MCM3 MED21 MNAT1 MYC NEDD4 NELFA NONO NR0B2 PCIF1 PHF8 PIN1 POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2K POLR2L PPIG PPP1CA PQBP1 PRPF19 RECQL5 SAFB SETD2 SMN1 SMN2 SMURF1 SND1 SUB1 SUPT5H TAF10 TBP TCEA1 TCEB3 TCERG1 TRAK1 TRAM2 U2AF2 UBC UBE2L3 UPF1 WAC WWP2 XAB2 XRCC5 ZNF74
Entrez ID		1660	5430
HPRD ID		04386	08916
Ensembl ID		ENSG00000135829	ENSG00000181222
Uniprot IDs		B3KU66 Q08211	P24928
PDB IDs		3LLM 3VYX 3VYY	2GHQ 2GHT 2LTO 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Spliceosomal SnRNP Assembly Nitrogen Compound Metabolic Process Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Viral Process Positive Regulation Of DNA Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Viral Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecular Complex Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Ribonucleoprotein Complex Biogenesis Negative Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Chromosome Organization Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Viral Genome Replication	Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation RNA Metabolic Process Positive Regulation Of Viral Transcription Gene Expression Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Viral Process MRNA Processing Cellular Macromolecule Biosynthetic Process RNA Processing MRNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Transcription-coupled Nucleotide-excision Repair Regulation Of RNA Metabolic Process DNA-templated Transcription, Initiation RNA Splicing Biosynthetic Process Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome Cellular Metabolic Process RNA Splicing, Via Transesterification Reactions 7-methylguanosine MRNA Capping Regulation Of RNA Biosynthetic Process 7-methylguanosine RNA Capping Cellular Response To DNA Damage Stimulus DNA Repair Nucleotide-excision Repair Regulation Of Metabolic Process Positive Regulation Of Gene Expression DNA-templated Transcription, Termination DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Transcription From RNA Polymerase I Promoter Positive Regulation Of Cellular Biosynthetic Process Metabolic Process Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter
Tagcloud ?			actb appropriately benchmark chosen confounding gapdh hormonal hprt1 hyperglycemia hyperglycemic lean myocardium normalization normalized obesity ppia predisposition reference reproducibility rpl13a scrutiny sdha select stably tbp tfrc underline ywhag zucker
Tagcloud (Difference) ?			actb appropriately benchmark chosen confounding gapdh hormonal hprt1 hyperglycemia hyperglycemic lean myocardium normalization normalized obesity ppia predisposition reference reproducibility rpl13a scrutiny sdha select stably tbp tfrc underline ywhag zucker
Tagcloud (Intersection) ?