POLR2A and ITCH

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
HPRD (in vitro, in vivo)

		POLR2A	ITCH
Gene Name		polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	itchy E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Nucleolus	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Activity DNA Binding DNA-directed RNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Ribonucleoprotein Complex Binding CXCR Chemokine Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Transcription, RNA-templated DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process Positive Regulation Of RNA Splicing PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription	Regulation Of Cell Growth Positive Regulation Of T Cell Anergy Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Inflammatory Response Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Protein K29-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Negative Regulation Of Alpha-beta T Cell Proliferation Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Defense Response To Virus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Protein Deubiquitination
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOD1/2 Signaling Pathway Signaling by NOTCH1 Hedgehog 'on' state Signaling by NOTCH1 in Cancer Class I MHC mediated antigen processing & presentation FBXW7 Mutants and NOTCH1 in Cancer Innate Immune System Downregulation of ERBB4 signaling Signaling by NOTCH Signaling by ERBB4 Activated NOTCH1 Transmits Signal to the Nucleus RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by Hedgehog Degradation of GLI1 by the proteasome Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		100 interactors: ABL1 ACTB ACTL6A ATM BARD1 BRCA1 CASP10 CCNH CCNK CCNL2 CCNT1 CDC14A CDK12 CDK7 CDK8 CDK9 CPSF1 CPSF2 CPSF3 CREBBP CSH2 CSNK2A1 CSTF1 CSTF2 CTCF CTD CTDP1 CTDSP1 CTDSP2 DHX9 ELL ERCC5 ERCC6 ERG FCP1 FUS GRB2 GTF2B GTF2E1 GTF2H4 HIST1H1C HNRNPF HNRNPU HTATSF1 ITCH IWS1 KAT2B KLK2 KMT2D LEO1 MCM3 MED21 MNAT1 MYC NEDD4 NELFA NONO NR0B2 PCIF1 PHF8 PIN1 POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2K POLR2L PPIG PPP1CA PQBP1 PRPF19 RECQL5 SAFB SETD2 SMN1 SMN2 SMURF1 SND1 SUB1 SUPT5H TAF10 TBP TCEA1 TCEB3 TCERG1 TRAK1 TRAM2 U2AF2 UBC UBE2L3 UPF1 WAC WWP2 XAB2 XRCC5 ZNF74	80 interactors: ARID1A ARRB2 ARRDC1 ARRDC3 ATN1 BECN1 CBL CBLC CDC34 CPSF6 CPSF7 CSNK2A1 CXCR4 CYLD DAZAP1 DTX1 DTX3L DVL2 ERBB4 EWSR1 FYN GNAI2 HNRNPL HNRNPUL1 JUN LAPTM5 LATS1 LITAF MAP2K4 MAPK8 MLANA N4BP1 NDFIP2 NEDD9 NFE2 NOTCH1 NUDT21 NUMB PABPC1 POLR2A POLR2B POLR2C POLR2E POU5F1 PRKACA RIPK1 RNF11 RPAP2 RPAP3 SCNN1A SCNN1B SF1 SGK3 SH3GL2 SMAD2 SMAD3 SMARCC1 SMARCC2 SMARCE1 SNX9 SPG20 STAM2 TP73 TRPC4 TRPV1 TRPV4 TXNIP UBAP2 UBAP2L UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2G1 UBE2J2 UBE2K UBE2L3 URI1 WBP2
Entrez ID		5430	83737
HPRD ID		08916	07565
Ensembl ID		ENSG00000181222	ENSG00000078747
Uniprot IDs		P24928	Q96J02
PDB IDs		2GHQ 2GHT 2LTO 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P	2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG
Enriched GO Terms of Interacting Partners?		Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation RNA Metabolic Process Positive Regulation Of Viral Transcription Gene Expression Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Viral Process MRNA Processing Cellular Macromolecule Biosynthetic Process RNA Processing MRNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Transcription-coupled Nucleotide-excision Repair Regulation Of RNA Metabolic Process DNA-templated Transcription, Initiation RNA Splicing Biosynthetic Process Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome Cellular Metabolic Process RNA Splicing, Via Transesterification Reactions 7-methylguanosine MRNA Capping Regulation Of RNA Biosynthetic Process 7-methylguanosine RNA Capping Cellular Response To DNA Damage Stimulus DNA Repair Nucleotide-excision Repair Regulation Of Metabolic Process Positive Regulation Of Gene Expression DNA-templated Transcription, Termination DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Transcription From RNA Polymerase I Promoter Positive Regulation Of Cellular Biosynthetic Process Metabolic Process Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus RNA Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Response To Growth Factor Positive Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Protein Ubiquitination Response To Organic Substance Cellular Response To Organic Substance Protein K48-linked Ubiquitination Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Protein Polyubiquitination Regulation Of Signaling Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nucleosome Disassembly TRIF-dependent Toll-like Receptor Signaling Pathway Programmed Cell Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Protein Catabolic Process Regulation Of Cellular Component Organization DNA-templated Transcription, Initiation Cell Death Death MRNA Splicing, Via Spliceosome
Tagcloud ?		actb appropriately benchmark chosen confounding gapdh hormonal hprt1 hyperglycemia hyperglycemic lean myocardium normalization normalized obesity ppia predisposition reference reproducibility rpl13a scrutiny sdha select stably tbp tfrc underline ywhag zucker	ascertain benzoin biweekly break clearance clinic convenience eradicating erosions ethanol individual irritation ns paint pb pe penile penis podophyllin regimens resin sequentially superficial supervised tincture treated wart warts week
Tagcloud (Difference) ?		actb appropriately benchmark chosen confounding gapdh hormonal hprt1 hyperglycemia hyperglycemic lean myocardium normalization normalized obesity ppia predisposition reference reproducibility rpl13a scrutiny sdha select stably tbp tfrc underline ywhag zucker	ascertain benzoin biweekly break clearance clinic convenience eradicating erosions ethanol individual irritation ns paint pb pe penile penis podophyllin regimens resin sequentially superficial supervised tincture treated wart warts week
Tagcloud (Intersection) ?