GADD45A and SH3GLB1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		GADD45A	SH3GLB1
Gene Name		growth arrest and DNA-damage-inducible, alpha	SH3-domain GRB2-like endophilin B1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Golgi Membrane Cytoplasm Mitochondrial Outer Membrane Extracellular Vesicular Exosome
	Molecular Function	Core Promoter Binding Protein Binding	Protein Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Activation Of MAPKKK Activity DNA Repair Negative Regulation Of Protein Kinase Activity Apoptotic Process Cell Cycle Arrest Centrosome Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process	Apoptotic Process Positive Regulation Of Protein Oligomerization Protein Oligomerization
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		65 interactors: ADAP1 ASCC2 AURKA BAG6 C14orf1 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B DCTN2 DNAJC13 EEF1A1 EEF1G FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 HIST1H1A HIST1H2AL HIST2H2BE HIST3H3 HIST4H4 IGHM IGSF21 JMJD1C KHSRP LMO4 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135	22 interactors: ADAM15 ADAM9 AMPH APP ARHGAP17 BAX BIN1 CMTM5 DNM1 DNM2 FUNDC1 GADD45A GADD45G HTT MTA1 PSMA1 SH3GLB2 SH3KBP1 SYNJ1 TFIP11 TPD52L2 ZNF576
Entrez ID		1647	51100
HPRD ID		00528	15333
Ensembl ID		ENSG00000116717	ENSG00000097033
Uniprot IDs		A5JUZ3 P24522	Q9Y371
PDB IDs		2KG4
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Cell Cycle Cell Cycle Process Regulation Of Gene Expression Mitotic Cell Cycle Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Organelle Organization DNA Packaging DNA Conformation Change Negative Regulation Of Cellular Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Aging Protein Complex Assembly Chromatin Organization Negative Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Death Death Positive Regulation Of Protein Metabolic Process Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Catabolic Process Response To Organic Substance DNA Damage Checkpoint Chromatin Assembly Or Disassembly Stress-induced Premature Senescence Immune Response Mitotic Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Gene Expression Mitotic DNA Damage Checkpoint Immune System Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cell Death Positive Regulation Of Metabolic Process Innate Immune Response Mitotic DNA Integrity Checkpoint Response To Toxic Substance Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Oxygen Levels	Endocytosis Learning Regulation Of Cell Cycle Regulation Of Catalytic Activity Apoptotic Process Programmed Cell Death Vesicle-mediated Transport Neuron Apoptotic Process Cell Death Death Activation Of MAPKKK Activity Positive Regulation Of P38MAPK Cascade Neuron Death Positive Regulation Of Catalytic Activity Establishment Of Vesicle Localization Positive Regulation Of Cellular Protein Metabolic Process Vesicle Localization Signaling Response To Radiation Single-organism Behavior Cell Communication Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Learning Or Memory Regulation Of P38MAPK Cascade Cognition Regulation Of Signaling Regulation Of Cellular Process Positive Regulation Of Proteolysis Synaptic Vesicle Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Behavior Positive Regulation Of Cell Death Regulation Of Apoptotic Process Establishment Of Organelle Localization Response To Light Stimulus Regulation Of Cell Death Response To Abiotic Stimulus Response To Ionizing Radiation Response To Stress Regulation Of Protein Binding Regulation Of Signal Transduction Positive Regulation Of Transport Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Membrane Permeability Organelle Localization Endoplasmic Reticulum Calcium Ion Homeostasis Synaptic Vesicle Endocytosis Signal Transduction
Tagcloud ?		2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Difference) ?		2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Intersection) ?